全部文献期刊会议图书|学者科研项目
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作者:Ting Liu , Lilan Zeng , Wenting Jiang ...
来源:[J].Nanomedicine: Nanotechnology, Biology, and Medicine(IF 6.93), 2015, Vol.11 (4), pp.947-958
摘要:Abstract(#br)Multidrug resistance is one of the greatest challenges in cancer therapy. Herein we described the synthesis of folate (FA)-conjugated selenium nanoparticles (SeNPs) as cancer-targeted nano-drug delivery system for ruthenium polypyridyl (RuPOP) exhibits strong fluores...
作者:Yi Cao , Ziyin Li , Lianzhi Mao ...
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2018
摘要:Abstract(#br)Multidrug resistance (MDR), defined as the cross-resistance of cancer cells toward a broad range of chemotherapeutic agents, is a universal and intractable problem in chemotherapy. The understanding of MDR mechanisms is essential to discover the potential biomarkers ...
作者:Lin Liu , Yanli Bao , Jinze Wang ...
来源:[J].Dyes and Pigments(IF 3.532), 2020, Vol.177
摘要:Abstract(#br)For clinical application, it is still giant challenge to reverse multidrug resistance. High efficiency, low toxicity and simplicity are key issues to design nanomedicines. Herein, we fabricated porphyrin-based drug self-framed delivery systems without any carrier v...
作者:Amit Kumar , Vikas Jaitak
来源:[J].European Journal of Medicinal Chemistry(IF 3.499), 2019, Vol.176, pp.268-291
摘要:... Currently, many drugs that are in clinical practice are having a high prevalence of side effect and multidrug resistance. Risk of tumors acquiring resistance to chemotherapy (multidrug resistance) remains a significant hurdle to the successful treatment of various types of ca...
作者:Yuedi Ding , Ying Peng , Lili Deng ...
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2017, Vol.167, pp.67-77
摘要:... Statins, the competitive inhibitors of HMG-CoA reductase, display potent anticancer activity and reversal ability of multidrug resistance in a variety of tumor cells, which is believed to be due to their inhibition of HMG-CoA reductase. Here, we determined the role of the...
作者:Xu Cheng , Xiaoli Zeng , Yan Zheng ...
来源:[J].Journal of Colloid And Interface Science(IF 3.172), 2020, Vol.565, pp.254-269
摘要:Abstract(#br)Multidrug resistance (MDR) is one of the major obstacles to clinical cancer chemotherapy. Herein, we designed new pH-sensitive pluronic micelles with the synergistic effects of oxidative therapy and MDR reversal. Pluronic (P123) was modified with α-tocopheryl succi...
作者:Yuqiong Xia , Mei Fang , Jingyu Dong ...
来源:[J].Colloids and Surfaces B: Biointerfaces(IF 3.554), 2018, Vol.170, pp.514-520
摘要:Abstract(#br)Multidrug resistance of tumour cells is one of the most important hurdles in tumour chemotherapy. To overcome the multidrug resistance, we constructed a pH-sensitive liposome formulation (pHSL) by loading tariquidar (TQR) and DOX simultaneously in this work. The form...
作者:Alena Braunová , Libor Kostka , Ladislav Sivák ...
来源:[J].Journal of Controlled Release(IF 7.633), 2017, Vol.245, pp.41-51
摘要:Abstract(#br)New amphiphilic diblock polymer nanotherapeutics serving simultaneously as a drug delivery system and an inhibitor of multidrug resistance were designed, synthesized, and evaluated for their physico-chemical and biological characteristics. The amphiphilic character o...
作者:Xiaoyan Li , Shuting Chen , Zelan Liu ...
来源:[J].Journal of Organometallic Chemistry(IF 2), 2018, Vol.871, pp.28-35
摘要:Abstract(#br)In order to develop novel radio-metal labeled probes for tumor multidrug resistance (MDR) detection, two [(C 5 H 4 -R) 99m Tc(CO) 3 ]-triphenylphosphonium (TPP) cations with methoxy groups, 99m Tc-6 and 99m Tc-7 were prepared from the ferrocenyl precursors and pu...
作者:Kelson Zawack , Will J. Love , Cristina Lanzas ...
来源:[J].Preventive Veterinary Medicine(IF 2.389), 2019, Vol.167, pp.137-145
摘要:Abstract(#br)Multidrug resistance is a serious problem raising the specter of infections for which there is no treatment. One of the most important tools in combating multidrug resistance is large scale monitoring programs, because they track resistance over large geographic area...

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