全部文献期刊会议图书|学者科研项目
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作者:Han Bai , Shaohua Liu , Shenghe Shi ...
来源:[J].Journal of Virological Methods(IF 1.9), 2020, Vol.276
摘要:Abstract(#br)Following the recommended use of the inactivated poliovirus vaccine from Sabin strains (sIPV) by the WHO, a D antigen-specific neutralizing monoclonal antibody (mAb) 1G10 that recognized the human poliovirus type 1 Sabin strain (PV-I Sabin) was produced for D-anti...
作者:Digamber Singh Chahar , Selvan Ravindran , S.S. Pisal
来源:[J].Biologicals(IF 1.616), 2020, Vol.63, pp.1-13
摘要:Abstract(#br)With the advancements in upstream technologies, the capacity for monoclonal antibody (mAb) production has transformed from a few milligrams to grams per liter. These titers lead to enormous pressure on downstream processes (DSPs), which need to be reworked to achieve...
作者:Rahul Sadavarte , Pedram Madadkar , Carlos DM Filipe ...
来源:[J].Journal of Chromatography B(IF 2.487), 2018, Vol.1073, pp.27-33
摘要:Abstract(#br)Monoclonal antibodies undergo various forms of chemical transformation which have been shown to cause loss in efficacy and alteration in pharmacokinetic properties of these molecules. Such modified antibody molecules are known as variants. They also display physical ...
作者:Mohamed Faisal , Isaac F. Standish , Mary Ann Vogelbein ...
来源:[J].Fish and Shellfish Immunology(IF 2.964), 2019, Vol.88, pp.464-471
摘要:Abstract(#br)This study reports the development of a monoclonal antibody (designated 3B10) against the muskellunge ( Esox masquinongy ) IgM. The 3B10 monoclonal antibody (mAb) belongs to the IgG3 kappa isotype. Western blotting demonstrated that 3B10 mAb reacted primarily to mus...
作者:Steffi Lütkecosmann , Thomas Faupel , Silvia Porstmann ...
来源:[J].Clinica Chimica Acta(IF 2.85), 2019, Vol.499, pp.87-92
摘要:... Different calibrators as recombinant human monoclonal antibodies as well as chimeric antibodies against the autoantigens of interest are described. A less cost-intensive and also more representative possibility covering different targets on the antigens is the utilization of...
作者:Susan E. Sloan , Kristy J. Szretter , Bharathi Sundaresh ...
来源:[J].Antiviral Research(IF 3.925), 2020
摘要:... The efficacy of VIS410, a broadly neutralizing human immunoglobulin IgG1 monoclonal antibody engineered to bind to the stem region of group 1 and 2 influenza A hemagglutinins, was explored in experimental human influenza infection. Healthy volunteers were inoculated with ...
作者:Zhao Bin Li , Peng Lei Cui , Jing Liu ...
来源:[J].Food Chemistry(IF 3.334), 2020, Vol.311
摘要:Abstract(#br)A hapten of sulfabenzamide was first synthesized to generate a monoclonal antibody that simultaneously recognized 32 sulfonamides. The computational simulation showed that the 3D conformation, molecular bend angle, molecular volume, electronic charge of core str...
作者:Le Wang , Yu-Chang Hu , Chang-Yi Xiao ...
来源:[J].Journal of Virological Methods(IF 1.9), 2018, Vol.257, pp.33-41
摘要:Abstract(#br)Aims(#br)To determine the value of a monoclonal antibody panel against a C-terminal conserved sequence polypeptide of human papillomavirus (HPV) L1 (a major capsid protein) for the detection of HPV in cervical exfoliated cells, as well as the potential of this antibody...
作者:Adam Hey , Marilyn Hill , Claudio Calonder ...
来源:[J].Reproductive Toxicology(IF 3.141), 2020, Vol.91, pp.142-146
摘要:Abstract(#br)The aim of this study was to directly test and measure in vivo , if placental transfer of monoclonal antibodies takes place in pregnant Göttingen Minipigs to assess their suitability for reproductive assessment of therapeutic monoclonal antibodies.(#br)Simulect®...
作者:Terence L. Kirley , Kenneth D. Greis , Andrew B. Norman
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2016, Vol.477 (3), pp.363-368
摘要:Abstract(#br)Simple and rapid methods for analysis of monoclonal antibody structure and post-translational modifications are increasingly needed due to the explosion of therapeutic monoclonal antibodies and monoclonal antibody applications. Mass spectral analysis is a powerful me...

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