全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Lina Leiss , Ercan Mutlu , Anne Øyan ...
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:Little is known about the role of glial host cells in brain tumours. However, supporting stromal cells have been shown to foster tumour growth in other cancers.
作者:Asmare Amuamuta , Tullayakorn Plengsuriyakarn , Kesara Na-Bangchang
来源:[J].BMC Complementary and Alternative Medicine(IF 2.082), 2017, Vol.17 (1)Springer
摘要:Cholangiocarcinoma (CCA) is an important public health problem in several tropical and subtropical parts of the world particularly Thailand. Chemotherapy of CCA is largely ineffective and discovery and development of effective alternative drugs is urgently needed. The objective o...
作者:Hideki Furuya , Yoshiko Shimizu , Paulette M. Tamashiro ...
来源:[J].Journal of Translational Medicine(IF 3.459), 2017, Vol.15 (1)Springer
摘要:Accumulating evidence suggests that sphingosine kinase 1 (SphK1)/sphingosine 1-phosphate pathway plays a pivotal role in colon carcinogenesis.
作者:Lakshmi Sripada , Kritarth Singh , Anastasiya V. Lipatova ...
来源:[J].Journal of Molecular Medicine(IF 4.768), 2017, Vol.95 (6), pp.641-651Springer
摘要:... Ectopic expression of miR-4485 in MDA-MB-231 breast carcinoma cells decreased the tumorigenicity in a nude mouse xenograft model. Furthermore, levels of both precursor and mature miR-4485 are decreased in tumor tissue of breast cancer patients. We conclude that the mitochondr...
作者:Wan-Su Park , Gab-jin Park , Seunghoon Han ...
来源:[J].Cancer Chemotherapy and Pharmacology(IF 2.795), 2017, Vol.80 (2), pp.363-369Springer
摘要:AGM-130 is a cyclin-dependent kinase inhibitor that exhibits dose-dependent efficacy in xenograft mouse models. During preclinical pharmacokinetic (PK) studies, mice and rats showed comparable PK parameters while dogs showed unusually high clearance (CL), which has made human PK ...
作者:Laurent Laborde , Fatos Oz , Mitko Ristov ...
来源:[J].Cancer Chemotherapy and Pharmacology(IF 2.795), 2017, Vol.80 (4), pp.869-878Springer
摘要:Everolimus is a drug used successfully in a number of different oncology indications, but significant on-target toxicities exist. We explored the possibility of improving the therapeutic index (TI) by studying alternative means of administering the drug based upon low continuous ...
作者:Andrey A. Bobko , Jason Evans , Nicholas C. Denko ...
来源:[J].Cell Biochemistry and Biophysics(IF 1.912), 2017, Vol.75 (2), pp.247-253Springer
摘要:... In summary, the results demonstrate the utility of EPR technique for non-invasive concurrent longitudinal monitoring of physiologically relevant chemical parameters of TME in mouse xenograft tumor models, including that under therapeutic intervention.
作者:Masafumi Miyai , Hiroyuki Tomita , Akio Soeda ...
来源:[J].Journal of Neuro-Oncology(IF 3.115), 2017, Vol.135 (3), pp.423-432Springer
摘要:... To determine these mechanisms, mouse models that recapitulate the molecular and histological characteristics of glioblastoma are required. Unlike in other malignancies, viral-mediated mouse models of glioblastoma rather than chemically induced mouse models have been developed...
作者:Christel Devaud , Benoît Rousseau , Sonia Netzer ...
来源:[J].Cancer Immunology, Immunotherapy(IF 3.637), 2013, Vol.62 (7), pp.1199-1210Springer
摘要:... To this purpose, we set up a reliable model of metastatic colon cancer through orthotopic implantation of luciferase-expressing human HT29 cells in immunodeficient mice. Using bioluminescence imaging to follow the outcome of colonic cancer cells, we showed that a systemic ...

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