全部文献期刊会议图书|学者科研项目
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作者:Prashant Gabani , Clifford G. Robinson , George Ansstas ...
来源:[J].Radiotherapy and Oncology(IF 4.52), 2018, Vol.127 (2), pp.310-317
摘要:Abstract(#br)Purpose(#br)Explore the patterns of use of extracranial radiation therapy (RT) in metastatic melanoma patients receiving immunotherapy, its potential association with OS, the impact of the site and timing of RT on clinical outcomes when combined with immunotherapy.(...
作者:Lars Bastholt , Inge Marie Svane , Jon Kroll Bjerregaard ...
来源:[J].European Journal of Cancer(IF 5.061), 2019, Vol.115, pp.61-67
摘要:Abstract(#br)Background and patients(#br)Between January 2007 and April 2014, 464 Danish patients received high-dose (HD) interleukin-2 (IL-2) and interferon (IFN) as first-line treatment for metastatic melanoma. Our data represent the largest cohort of patients with metastatic melanoma...
作者:Marius Ilie , Elodie Long-Mira , Elisa Funck-Brentano ...
来源:[J].Journal of the American Academy of Dermatology(IF 4.906), 2015, Vol.72 (5), pp.786-793
摘要:Background(#br)It can be useful to assess the NRAS mutation status in patients with metastatic melanoma because NRAS -activating mutations confer resistance to RAF inhibitors, and NRAS- mutated patients appear to be sensitive to mitogen-activated protein kinase (MEK) inhibitors.(...
作者:Guy Ben-Betzalel , Yael Steinberg-Silman , Ronen Stoff ...
来源:[J].European Journal of Cancer(IF 5.061), 2019, Vol.108, pp.61-68
摘要:Abstract(#br)Immunotherapy with anti–programmed cell death-1 (PD-1) agents is an effective treatment for metastatic melanoma. Recent data hint at better response to therapy for patients over age 65 years. Patients with metastatic melanoma in their 80's and 90's pose a clin...
作者:Jüri Teras , Hidde M. Kroon , John F. Thompson ...
来源:[J].European Journal of Surgical Oncology(IF 2.614), 2020, Vol.46 (2), pp.272-276
摘要:Abstract(#br)Background(#br)Isolated limb infusion (ILI) with cytotoxic agents is a simple and effective treatment option for patients with melanoma in-transit metastases (ITMs) confined to an extremity. Data for ILIs performed in Europe are sparse and to date no Eastern Europe...
作者:Sara Valpione , Matteo S. Carlino , Johanna Mangana ...
来源:[J].European Journal of Cancer(IF 5.061), 2018, Vol.91, pp.116-124
摘要:Abstract(#br)Background(#br)Most metastatic melanoma patients treated with BRAF inhibitors (BRAFi) ± MEK inhibitors (MEKi) eventually progress on treatment. Along with acquired resistance due to genetic changes, epigenetic mechanisms that could be reversed after BRAFi disconti...
作者:J. Schlabe , K.A. Shah , F. Sheerin ...
来源:[J].International Journal of Oral & Maxillofacial Surgery(IF 1.521), 2018
摘要:Abstract(#br)Regression of metastatic melanoma is very rare and occurs in only 0.23% of cases. Metastasis to the oral cavity is particularly uncommon and accounts for only 1–3% of all oral malignancies. This report presents a case of spontaneous and complete regression of a metastatic melanoma...
作者:L. Kandolf Sekulovic , K. Peris , A. Hauschild ...
来源:[J].European Journal of Cancer(IF 5.061), 2017, Vol.75, pp.313-322
摘要:Abstract(#br)Background(#br)Despite the efficacy of innovative treatments for metastatic melanoma, their high costs has led to disparities in cancer care among different European countries. We analysed the availability of these innovative therapies in Europe and estimated the num...
作者:Ruinan Yang , Goutam Mondal , Rachel A. Ness ...
来源:[J].Journal of Controlled Release(IF 7.633), 2017, Vol.249, pp.32-41
摘要:Abstract(#br)Melanoma is the most aggressive type of skin cancer. It is highly metastatic, migrating through lymph nodes to distant sites of the body, especially to lungs, liver and brain. Systemic chemotherapy remains the mainstay of treatment; however, the development of multi...
作者:Guy Ben-Betzalel , Erez N. Baruch , Ben Boursi ...
来源:[J].European Journal of Cancer(IF 5.061), 2018, Vol.101, pp.229-235
摘要:Abstract(#br)BRAF inhibitors (BRAFi) and MEK inhibitors (MEKi) are among the cornerstones of metastatic melanoma therapy demonstrating excellent response rates with duration of 7–12 m.(#br)Long-term benefit from these agents was reported in patients with normal lactate dehydro...

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