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作者:Valerie Arpino , Michael Brock , Sean E. Gill
来源:[J].Matrix Biology(IF 3.19), 2015, Vol.44-46, pp.247-254
摘要:Abstract(#br)Tissue inhibitors of metalloproteinases (TIMPs), which inhibit matrix metalloproteinases (MMPs) as well as the closely related, a disintegrin and metalloproteinases (ADAMs) and ADAMs with thrombospondin motifs (ADAMTSs), were traditionally thought to control extracel...
作者:Alexander J. Baker-Williams , Fiza Hashmi , Marek A. Budzyński ...
来源:[J].Cell Reports, 2019, Vol.28 (7), pp.1894-1906.e6
摘要:Summary(#br)The extracellular molecular chaperone heat shock protein 90 (eHSP90) stabilizes protease client the matrix metalloproteinase 2 (MMP2), leading to tumor cell invasion. Although co-chaperones are critical modulators of intracellular HSP90:client function, how the eHSP...
作者:Marylise Duperthuy , Bernt Eric Uhlin , Sun Nyunt Wai
来源:[J].Trends in Microbiology(IF 8.434), 2015, Vol.23 (11), pp.667-668
摘要:The appearance of bacterial biofilms involves secretion of polysaccharides and proteins that form an extracellular matrix embedding the bacteria. Proteases have also been observed, but their role has remained unclear. Smith and co-workers have now found that proteolysis can contr...
作者:Dalit Talmi-Frank , Zeev Altboum , Inna Solomonov ...
来源:[J].Cell Host & Microbe(IF 12.609), 2016, Vol.20 (4), pp.458-470
摘要:... We used a combined genomic and proteomic approach to investigate the role of extracellular matrix (ECM) proteolysis in achieving this balance in the lung during influenza virus infection. We identified the membrane-tethered matrix metalloprotease MT1-MMP as a prominent host-E...
作者:Nicolas Etique , Laurie Verzeaux , Stéphane Dedieu ...
来源:[J].BioMed Research International, 2013, Vol.2013
摘要:... Proteinases capable of degrading extracellular matrix (ECM), called matrix proteinases in this paper, are mainly serine proteinases: the activators of plasminogen into plasmin, tissue-type (tPA) and urokinase-type (uPA) plasminogen activators, and the members of the matrix me...
作者:Xiaoying Wang , Anna Rosell , Eng H. Lo
来源:[J].CNS & Neurological Disorders - Drug Targets(IF 3.769), 2008, Vol.7 (3), pp.235-242
摘要:... Emerging experimental studies demonstrate that the breakdown of neurovascular matrix initiates blood – brain barrier disruption with edema and/or hemorrhage. Perturbation of extracellular homeostasis triggered by dysregulated extracellular proteases may underlie proces...
作者:P. GAUDIN , C. TROAME , F. MONIER ...
来源:[J].Annales de Biologie Clinique(IF 0.298), 1998, Vol.56 (6), pp.661-9
摘要:The zinc metalloproteinases (MMPs or matrixins) are capable of damaging most of the constituents of the extra-cellular matrix and the basement membrane. The matrix proteolysis is the result of an imbalance both in the turnover of these constituants and in the ratio of the tissue ...
作者:Francis G. Spinale , Joseph S. Janicki , Michael R. Zile
来源:[J].Circulation Research(IF 11.861), 2013, Vol.112 (1), pp.195-208
摘要:The extracellular matrix (ECM) is a complex entity containing a large portfolio of structural proteins, signaling molecules, and proteases. Changes in the overall integrity and activational state of these ECM constituents can contribute to tissue structure and function, which is ...

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