全部文献期刊会议图书|学者科研项目
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作者:Sung-Ho Kim , Qing-Mei Pei , Ping Jiang ...
来源:[J].Experimental Cell Research(IF 3.557), 2020
摘要:... MUC5AC is a major mucin glycoprotein that is hypersecreted in asthmatic individuals. Vascular endothelial growth factor (VEGF) has been implicated in inflammatory and airway blood vessel remodeling in asthmatics. Our previous studies indicate that VEGF upregulates MUC5AC expr...
作者:Shouzhen Wu , Hailong Li , Lijuan Yu ...
来源:[J].Immunology Letters(IF 2.337), 2017, Vol.192, pp.20-26
摘要:Abstract(#br)The manifest and important feature in respiratory diseases, including asthma and COPD (chronic obstructive pulmonary disease), is the increased numbers and hypersecretion of goblet cells and overexpression of mucins, especially Muc5ac. Many proinflammatory cytokin...
作者:Burak Ulkumen , Burcu Artunc Ulkumen , Muhammet Burak Batir ...
来源:[J].Journal of Voice(IF 1.55), 2019
摘要:SUMMARY(#br)Objective(#br)The aim of this study is to reveal physiological expression and distribution of nuclear factor-kappa B (NF-κB) and MUC 5 subtype AC (MUC5AC) in rat laryngeal mucosa and to find out the effect of pregnancy and glucocorticoid treatment on these biomol...
作者:Lindsay M. Garvin , Yajun Chen , Jesse M. Damsker ...
来源:[J].Pulmonary Pharmacology & Therapeutics(IF 2.543), 2016, Vol.38, pp.17-26
摘要:... IL-1β upregulates the MUC5AC mucin gene in part via the transcription factors NFκB while the glucocorticoid Dexamethasone (Dex) transcriptionally represses MUC5AC expression by Dex-activated GR binding to two GRE cis -sites in the MUC5AC promoter in lung epithelial cells....
作者:Takahito Oyanagi , Takumi Takizawa , Akira Aizawa ...
来源:[J].Allergology International, 2017, Vol.66 (1), pp.75-82
摘要:... MUC5AC expression is regulated by a variety of stimuli such as cytokines. Little is known about the role of interferon (IFN)-γ in MUC5AC expression in human bronchial epithelial cells.(#br)Methods(#br)Human pulmonary mucoepidermoid carcinoma cell line (NCI-H292) and norm...
作者:Vishwanatha R.A.P. Reddy , Ivan Trus , Hans J. Nauwynck
来源:[J].Virus Research(IF 2.745), 2017, Vol.227, pp.135-142
摘要:... Hence, in the present study, we first examined if the main respiratory mucins, MUC5AC and MUC5B, are expressed in the mucosae of larynx, trachea and bronchi of mock-inoculated and ILTV infected chickens. Second, the tracheas with plugs/casts were stained for mucins (MUC5AC...
作者:Wanming Hao , Jing Wang , Yu Zhang ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2017, Vol.493 (2), pp.979-984
摘要:... MUC5AC protein is a major component of airway mucus. Here, we showed that interleukin (IL)-13 induced MUC5AC production and secretion, and leptin expression in the human bronchial epithelial cell line-16 (HBE16) cells in a concentration-dependent manner. Leptin knockdown supp...
作者:Mi Ho Jeong , Yong Joo Park , Ha Ryong Kim ...
来源:[J].Chemico-Biological Interactions(IF 2.967), 2019, Vol.305, pp.119-126
摘要:... MUC5AC, the predominant mucin gene expressed in airways, is associated with obstructive respiratory disease pathogenesis. Therefore, in this study, we elucidated the relationship between PHMG-p and MUC5AC overexpression. First, in immunofluorescence studies, the bronchial epi...
作者:Karam Kim , Hye Jeong Kim , Bert Binas ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2018
摘要:... We previously demonstrated that S100A8, S100A9, and S100A12 induce production and secretion of MUC5AC, a major mucin in the conducting airway mucosa. The purpose of this study was to determine the involvement of NLRP3 inflammasome in, and the contribution of ATP to, S100...
作者:Hyung Gyun Na , Yong-Dae Kim , Yoon Seok Choi ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2018, Vol.503 (1), pp.316-322
摘要:... In human airway NCI-H292 epithelial cells, the effects of allethrin and prallethrin and its signaling pathway for airway mucin, especially MUC5AC, were investigated by reverse transcriptase-polymerase chain reaction (RT-PCR), real-time PCR, and enzyme-linked immunosorbent ass...

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