全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Yoshiyuki Mizushina , Jun Maeda , Yasuhiro Irino ...
来源:[J].International Journal of Molecular Sciences(IF 2.464), 2011, Vol.12 (2), pp.1115DOAJ
摘要:... In this study, we chemically synthesized three intermediate compounds between VK2 and VK3, namely MK-3, MK-2 and MK-1, and investigated the inhibitory effects of all five compounds on the activity of mammalian pols. Among these compounds, MK-2 was the strongest inhibitor o...
作者:Takeshi Azuma , Hiromi Yoshida , Masaru Yoshida ...
来源:[J].International Journal of Molecular Sciences(IF 2.464), 2011, Vol.12 (2), pp.1115-1132DOAJ
摘要:... In this study, we chemically synthesized three intermediate compounds between VK2 and VK3, namely MK-3, MK-2 and MK-1, and investigated the inhibitory effects of all five compounds on the activity of mammalian pols. Among these compounds, MK-2 was the strongest inhibitor o...
作者:Songnian Lin , Sunita Malkani , Matthew Lombardo ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2015, Vol.25 (22), pp.5402-5408Elsevier
摘要:Abstract(#br)Several series of novel non-thiourea-containing aminopyrazine derivatives were designed based on the MK-2 inhibitors 1-(2-aminopyrazin-3-yl)methyl-2-thioureas. These compounds were synthesized and evaluated for their inhibitory activity against MK-2 enzyme in vitr...
作者:John I. Trujillo , Marvin J. Meyers , David R. Anderson ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2007, Vol.17 (16), pp.4657-4663Elsevier
摘要:Abstract(#br)A structure–activity relationship study was conducted on a series of tetrahydro-β-carboline-1-carboxylic acid analogs in order to identify the key functionality responsible for activity against the mitogen-activated protein kinase-activated protein kinase 2 enzyme (MK-2...
作者:David R. Anderson , Shridhar Hegde , Emily Reinhard ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2005, Vol.15 (6), pp.1587-1590Elsevier
摘要:Abstract(#br)A class of inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2) was discovered. These compounds have demonstrated activity against the enzyme with IC 50 values as low as 130 nM and suppress the expression of TNFα in U937 cells. These rep...
作者:Songnian Lin , Matthew Lombardo , Sunita Malkani ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2009, Vol.19 (12), pp.3238-3242Elsevier
摘要:Abstract(#br)Novel 1-(2-aminopyrazin-3-yl)methyl-2-thioureas are described as inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2). These compounds demonstrate potent in vitro activity against the enzyme with IC 50 values as low as 15 nM, and suppre...
作者:Ming Hao , Hong Ren , Fang Luo ...
来源:[J].IJMS(IF 2.464), 2012, Vol.13 (6), pp.7057-7079MDPI
摘要:Mitogen-activated protein kinase-activated protein kinase 2 (MK-2) has been identified as a drug target for the treatment of inflammatory diseases. Currently, a series of thiourea analogs as potent MK-2 inhibitors were studied using comprehensive computational methods by 3D-QS...
作者:Yoshiyuki Mizushina , Jun Maeda , Yasuhiro Irino ...
来源:[J].IJMS(IF 2.464), 2011, Vol.12 (2), pp.1115-1132MDPI
摘要:... In this study, we chemically synthesized three intermediate compounds between VK2 and VK3, namely MK-3, MK-2 and MK-1, and investigated the inhibitory effects of all five compounds on the activity of mammalian pols. Among these compounds, MK-2 was the s...
作者:Zhaoqi Yang , Pinghua Sun , Weimin Chen
来源:[J].Letters in Drug Design & Discovery(IF 0.845), 2007, Vol.4 (8), pp.557-561Bentham
摘要:Mitogen-activated protein kinase-activated protein kinase 2 (MK-2) plays an important role in treatment of inflammatory disease such as rheumatoid arthritis. CoMFA was conducted on thirty-one analogs displaying variable inhibition of MK-2 to determine the structural requirements ...
作者:Frank Lovering , Steve Kirincich , Weiheng Wang ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2009, Vol.17 (9), pp.3342-3351Elsevier
摘要:Abstract(#br)A novel series of inhibitors for mitogen activated protein kinase-activated protein kinase 2 (MK-2) are reported. These squarate based inhibitors were identified via a high-throughput screen. An MK2 co-structure with the starting ligand was obtained and a structure b...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×