全部文献期刊会议图书|学者科研项目
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作者:Philip J Coates , Sally A Lorimore , Brigitte A Rigat ...
来源:[J].Oncogene(IF 7.357), 2001, Vol.20 (48), pp.7096-7097
摘要:Abstract(#br)Studies of the response of p53- lacZ transgenic mice have uncovered an unexpected induction of endogenous acid-β-galactosidase activity following whole body irradiation. Strong induction of endogenous enzyme activity is seen in a variety of mouse strains common...
作者:Joost H.M van Delft , Angela Bergmans , Fred J van Dam ...
来源:[J].Mutation Research - Genetic Toxicology and Environmental Mutagenesis(IF 2.22), 1998, Vol.415 (1-2), pp.85-96
摘要:... We have used λlacZ transgenic mice to study alkylation-induced mutagenesis in vivo in (a) lacZ and hprt in spleen cells, and (b) lacZ and Dlb-1 in small intestine from λlacZ +/0 / Dlb-1 a/b mice. Induction of mutations by ethyl- and methylnitrosourea (ENU, MNU) and ethyl m...
作者:Hiroshi Ogawa , Tohru Ohyama , Eiji Katsura ...
来源:[J].Mut.Res.-Genetic Toxicology and Environmental Mutagenesis(IF 2.22), 1997, Vol.394 (1), pp.141-151
摘要:Abstract(#br)pUC19– lacZ C 141 DNA contains a proline codon at positions 141 to 143, where an alanine codon normally appears in the original lacZ gene. pUC19– lacZ C 141 DNA was produced using site-directed mutagenesis. After transfection of pUC19– lacZ C 141 DNA into lacZ...
作者:Jason M. O’Brien , Marc A. Beal , Carole L. Yauk ...
来源:[J].Scientific Reports(IF 2.927), 2016, Vol.6 (1), pp.40-47
摘要:... We recovered lacZ transgenes from sperm 42 days after a 28-day exposure to benzo(a)pyrene (BaP, 100 mg/kg/day) to assess mutations arising in dividing spermatogonia. BaP caused a 3.4-fold increase in lacZ mutant frequency over controls which increased to 4.1-fold after clonal...
作者:Kazushi Aoto , Lisa L. Sandell , Naomi E. Butler Tjaden ...
来源:[J].Developmental Biology(IF 3.868), 2015, Vol.402 (1), pp.3-16
摘要:... Firstly, using the F10N enhancer of the Mef2c gene ( Mef2c - F10N ) linked to LacZ, we generated transgenic mice ( Mef2c - F10N-LacZ ) that express LacZ in the majority, if not all migrating NCC that delaminate from the neural tube. Mef2c - F10N -LacZ then continues to be exp...
作者:S.-T Liang , M Ehrenberg , P Dennis ...
来源:[J].Journal of Molecular Biology(IF 3.905), 1999, Vol.288 (4), pp.521-538
摘要:... one has wild-type spc and lac operons and the other has a lac operon deletion, a wild-type spc operon, and a P spc - rplN-lacZ fusion operon lacking the normal control sites of the spc operon ( rplN is the first gene in the spc operon of ribosomal proteins). The decay of...
作者:Luitpold Fried , Jürgen Lassak , Kirsten Jung
来源:[J].Journal of Microbiological Methods(IF 2.161), 2012, Vol.91 (3), pp.537-543
摘要:Abstract(#br)β-Galactosidase encoded by lacZ remains a popular reporter enzyme. Here, we present three fast and convenient tools that facilitate rapid construction of reporter lacZ fusions. The first enables the simple generation of lacZ ( slacZ )-based chromosomally encoded r...
作者:Allen L Honeyman , Christopher K Cote , Roy Curtiss
来源:[J].Journal of Microbiological Methods(IF 2.161), 2002, Vol.49 (2), pp.163-171
摘要:... The lacZ gene from Escherichia coli has been used very effectively to quantify such regulated activities in many different organisms. This report describes the construction of a pair of plasmids that may be used for either transcriptional or translational lacZ gene fusions i...
作者:A. Hashimoto-Gotoh , R. Yoshikawa , T. Miyazawa
来源:[J].Biologicals(IF 1.616), 2015, Vol.43 (5), pp.363-368
摘要:... On the other hand, LacZ marker rescue (LMR) assay detects infectious gammaretroviruses by transducing LacZ marker gene to the target cells, which shows lacZ -positive foci if the infectious virus is present. In this study, we compared LMR and S+L− assays for detection of...
作者:Heidi Giese , Wendy K Snyder , Conny van Oostrom ...
来源:[J].Mut.Res.-Genetic Toxicology and Environmental Mutagenesis(IF 2.22), 2002, Vol.514 (1), pp.153-163
摘要:... To investigate the rate of age-related mutation accumulation in the absence of p53, we crossed Trp53 null mice with transgenic mice harboring a lacZ mutational target gene. In the hybrid animals, lacZ mutation frequencies at early age (i.e. at about 2 months) were found to b...

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