全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Jing Liu , Bo Jin , Hang Su ...
来源:[J].BMC Cancer(IF 3.333), 2019, Vol.19 (1), pp.1-6DOAJ
摘要:... This study aimed to report a case baring acquired EGFR L858R/L718Q mutation in the central nervous system induced by osimertinib, which was successfully overcome using afatinib. Case presentation A 65-year-old female patient was diagnosed with stage IV non-small-cell lung ade...
作者:Liu Jing , Jin Bo , Su Hang ...
来源:[J].BMC cancer(IF 3.333), 2019, Vol.19 (1), pp.702PubMed
摘要:... This study aimed to report a case baring acquired EGFR L858R/L718Q mutation in the central nervous system induced by osimertinib, which was successfully overcome using afatinib.(#br)CASE PRESENTATION(#br)A 65-year-old female patient was diagnosed with stage IV non-small-cell ...
作者:Liu Jing , Jin Bo , Su Hang ...
来源:[J].BMC cancer(IF 3.333), 2019, Vol.19 (1), pp.702PubMed
摘要:... This study aimed to report a case baring acquired EGFR L858R/L718Q mutation in the central nervous system induced by osimertinib, which was successfully overcome using afatinib.(#br)CASE PRESENTATION(#br)A 65-year-old female patient was diagnosed with stage IV non-small-cell ...
作者:Callegari D , Ranaghan K E , Woods C J ...
来源:[J].Chemical science(IF 8.314), 2018, Vol.9 (10), pp.2740-2749PubMed
摘要:... The mutation of a residue in the P-loop (L718Q) was shown to cause resistance to osimertinib, but the molecular mechanism of this process is unknown. Here, we investigated the inhibitory process for EGFR T790M (susceptible to osimertinib) and EGFR T790M/L718Q (resistant to os...
作者:D. Callegari , K. E. Ranaghan , C. J. Woods ...
来源:[J].Chemical Science, 2018, Vol.9 (10), pp.2740-2749PubMed
摘要:... The mutation of a residue in the P-loop (L718Q) was shown to cause resistance to osimertinib, but the molecular mechanism of this process is unknown. Here, we investigated the inhibitory process for EGFR T790M (susceptible to osimertinib) and EGFR T790M/L718Q (resistant to ...
作者:黄清源
来源:[D].上海交通大学  2018CNKI
摘要:...Part IV:We used the genetically engeering mouse models the mutant EGFR,to investigate whether L718Q mutation could lead to osimertinib resistance in vivo.We continuously treated the EGFR~(L858R-T790M)(EGFR TL)mouse model with osimertinib (5mg/kg,P.O.,Q.D.),to establish the ...
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