全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Ashish A. Kulkarni , Vijay Elakkya Vijaykumar , Siva Kumar Natarajan ...
来源:[J].Nanomedicine: Nanotechnology, Biology, and Medicine(IF 6.93), 2016, Vol.12 (7), pp.1853-1861Elsevier
摘要:... Here, we developed liposomes encapsulating a multi-receptor tyrosine kinase inhibitor (XL184) to explore the possibility of improving intratumoral concentration, enhancing antitumor efficacy and reducing toxicities. The liposomes showed increased cytotoxicity than XL184, and ...
作者:Christian Schmidt-Lauber , Saliha Harrach , Thomas Pap ...
来源:[J].PLOS ONE(IF 3.73), 2012, Vol.7 (12)PLOS
摘要:Tyrosine kinase inhibitors (TKIs) are effective in treating malignant disorders and were lately suggested to have an impact on non-malignant diseases. However, in some inflammatory conditions like rheumatoid arthritis (RA) the in vivo effect seemed to be moderate. As most TK...
作者:Hugo Albrecht , Eric Kübler
来源:[J].Pharmaceutics, 2019, Vol.11 (9)MDPI
摘要:... While the recent clinical launch of several kinase inhibitors led to tremendous progress, these targeted agents tend to be of non-specific nature within the kinase target class. Moreover, target mediated adverse effects limit the exploitation of some very promising kinase tar...
作者:Albrecht Hugo , Kübler Eric
来源:[J].Pharmaceutics, 2019, Vol.11 (9)PubMed
摘要:... While the recent clinical launch of several kinase inhibitors led to tremendous progress, these targeted agents tend to be of non-specific nature within the kinase target class. Moreover, target mediated adverse effects limit the exploitation of some very promising kinase tar...

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