全部文献期刊会议图书|学者科研项目
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作者:Yuanyuan Fu , Yanzhi Guo , Yuelong Wang ...
来源:[J].Computational Biology and Chemistry(IF 1.793), 2015, Vol.56, pp.41-48
摘要:... The intrinsic disorder proteins (IDPs) with unstable structures can promote the promiscuity of hubs and also involve in many disease pathways, so they also could serve as potential drug targets. Moreover, proteins with similar functions measured by semantic similarity of ...
作者:Michael Vincent , Santiago Schnell
来源:[J].Computational Biology and Chemistry(IF 1.793), 2019, Vol.83
摘要:... While this property has gained considerable interest within the past two decades, disorder poses substantial challenges to experimental characterization efforts. In effect, numerous computational tools have been developed to predict disorder from primary sequences, however, i...
作者:Eugenia I. Deryusheva , Alexander I. Denesyuk , Konstantin Denessiouk ...
来源:[J].International Journal of Biological Macromolecules(IF 2.596), 2018
摘要:... In the present work, we studied the relationship between the location of the ‘black’ and ‘gray’ structural clusters in parvalbumins and the location of the amino acid sequence regions with a tendency for intrinsic disorder. This analysis revealed that in parvalbumins...
作者:Chengquan Han , Chenchen Cui , Xupeng Xing ...
来源:[J].International Journal of Biological Macromolecules(IF 2.596), 2019, Vol.136, pp.962-979
摘要:... Thus we tried to explore the complicated DNA demethylation in pre-implantation embryos from the intrinsic disorder perspective. These five biological macromolecules all have DNA demethylation-related functional domains. They can work together to fulfill DNA demethylation in...
作者:Fanchi Meng , Vladimir N. Uversky , Lukasz Kurgan
来源:[J].Cellular and Molecular Life Sciences(IF 5.615), 2017, Vol.74 (17), pp.3069-3090
摘要:Computational prediction of intrinsic disorder in protein sequences dates back to late 1970 and has flourished in the last two decades. We provide a brief historical overview, and we review over 30 recent predictors of disorder. We are the first to also cover predictors of mol...
作者:Lilia M. Iakoucheva , Celeste J. Brown , J.David Lawson ...
来源:[J].Journal of Molecular Biology(IF 3.905), 2002, Vol.323 (3), pp.573-584
摘要:... To test for a generalized involvement of intrinsic disorder in signaling and cancer, we applied a neural network predictor of natural disordered regions (PONDR VL-XT) to four protein datasets: human cancer-associated proteins (HCAP), signaling proteins (AfCS), eukaryotic pr...
作者:Vladimir N. Uversky
来源:[J].Cellular and Molecular Life Sciences(IF 5.615), 2017, Vol.74 (17), pp.3065-3067
摘要:The concept of protein intrinsic disorder persistently penetrates into all areas of modern protein science. It cannot be ignored anymore, and cannot be shrugged off, as it represents a vital feature (or, more correctly, a broad spectrum of important features), which, when added t...
作者:Joseph B. Ahrens , Janelle Nunez-Castilla , Jessica Siltberg-Liberles
来源:[J].Cellular and Molecular Life Sciences(IF 5.615), 2017, Vol.74 (17), pp.3163-3174
摘要:Conformational flexibility conferred though regions of intrinsic structural disorder allows proteins to behave as dynamic molecules. While it is well-known that intrinsically disordered regions can undergo disorder-to-order transitions in real-time as part of their function, we a...
作者:Marc S. Cortese , Vladimir N. Uversky , A. Keith Dunker
来源:[J].Progress in Biophysics and Molecular Biology(IF 2.914), 2008, Vol.98 (1), pp.85-106
摘要:... This review examines the roles of intrinsic disorder (ID) in signaling scaffold protein function. Several well-characterized scaffold proteins with structurally and functionally characterized ID regions are used here to illustrate the importance of ID for scaffolding func...
作者:Iga Korneta , Janusz M Bujnicki
来源:[J].PLoS Computational Biology(IF 4.867), 2017, Vol.8 (8)
摘要:... In recent years, many spliceosomal proteins have been found to exhibit intrinsic disorder, that is to lack stable native three-dimensional structure in solution. Building on the previous body of proteomic, structural and functional data, we have carried out a systematic bioin...

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