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作者:Lei Zhang , Xue Shan , Xia Meng ...
来源:[J].Biomaterials(IF 7.604), 2019, Vol.223
摘要:... Integrins β3 (αvβ3 and αIIbβ3) are an important cell adhesion molecular family, overexpressed on both cell membrane and perinuclear region of prostate cancer cells, and play a key role in the progression and metastasis of prostate cancer, making them an attractive targ...
作者:Franco Pandolfi , Laura Franza , Simona Altamura ...
来源:[J].Clinical Therapeutics(IF 2.23), 2017, Vol.39 (12), pp.2420-2436
摘要:Abstract(#br)Purpose(#br)Although the role of integrins has been described in a variety of diseases, these roles seem to be distinct. To date, no study has attempted to provide links to the various pathways by which such integrins can be involved in these diverse disease settings...
作者:Leonie Schittenhelm , Leonie Schittenhelm , Leonie Schittenhelm ...
来源:[J].Frontiers in Immunology, 2017, Vol.8
摘要:... β2 integrins are important adhesion and signaling molecules that are exclusively expressed on leukocytes. The four β2 integrins (CD11a, CD11b, CD11c, and CD11d paired with the β2 chain CD18) play important roles in regulating three key aspects of immune cell function: rec...
作者:Tsutomu Fujimura , Shigeru Moriwaki , Genji Imokawa ...
来源:[J].Journal of Dermatological Science(IF 3.52), 2006, Vol.45 (1), pp.45-53
摘要:Summary(#br)Background(#br)In vivo functions of integrins in dermis have been investigated using several types of genetically integrin deficient mice. However, there are few studies to clarify actual in vivo functions of integrins in the dermis using normal type animals.(#br...
作者:ChangDong Lin , YouHua Zhang , Kun Zhang ...
来源:[J].Immunity(IF 19.795), 2019, Vol.50 (1), pp.137-151.e6
摘要:... By inducing selective binding of Hsp90 to α4 integrins, but not β2 integrins, fever increased α4-integrin-mediated T cell adhesion and transmigration. Mechanistically, Hsp90 bound to the α4 tail and activated α4 integrins via inside-out signaling. Moreover, the N an...
作者:Julio César Villegas-Pineda , Olga Lilia Garibay-Cerdenares , Verónica Ivonne Hernández-Ramírez ...
来源:[J].Pathology - Research and Practice(IF 1.213), 2015, Vol.211 (12), pp.973-981
摘要:Abstract(#br)Integrins are adhesion molecules whose expression is upregulated during different cellular processes such as adhesion, growth, proliferation, migration, survival and differentiation, all of which are involved in neoplastic development. Several reports have linked ...
作者:Linlang Guo , Fan Zhang , Yingqian Cai ...
来源:[J].Pathology - Research and Practice(IF 1.213), 2009, Vol.205 (12), pp.847-853
摘要:Abstract(#br)Integrins are heterodimeric transmembrane receptors consisting of 18 α and 8 β subunits. Heterodimer composition of α and β subunits has a potential for determining tumor subtypes of human lung cancer. The purpose of this study was to investigate the expressi...
作者:Anne-Florence eBlandin , Guillaume eRenner , Isabelle eLelong-Rebel ...
来源:[J].Frontiers in Pharmacology, 2015, Vol.6
摘要:Integrins belong to a large family of αβ heterodimeric transmembrane proteins first recognized as adhesion molecules that bind to dedicated elements of the extracellular matrix and also to other surrounding cells. As important sensors of the cell microenvironment, they regu...
作者:Aki Manninen
来源:[J].Experimental Cell Research(IF 3.557), 2015, Vol.334 (2), pp.337-349
摘要:... Integrins constitute the largest family of such receptors binding to the ECM. Integrins have been shown to be essential for the establishment of initial polarity cues that define the position of the basal domain and thereby govern the orientation of the forming apico-basal ax...
作者:Mark S. Filla , Jennifer A. Faralli , Jennifer L. Peotter ...
来源:[J].Experimental Eye Research(IF 3.026), 2016, Vol.158
摘要:Abstract(#br)Integrins are a family of heterodimeric transmembrane receptors that mediate adhesion to the extracellular matrix (ECM). In addition to their role as adhesion receptors, integrins can act as ‘‘bidirectional signal transducers’’ that coordinate a large nu...

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