全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Kamila Romanowski , Leslie Y. Chiang , David Z. Roth ...
来源:[J].BMC Infectious Diseases(IF 3.025), 2017, Vol.17 (1)Springer
摘要:Every year, over 1 million people develop isoniazid (INH) resistant tuberculosis (TB). Yet, the optimal treatment regimen remains unclear. Given increasing prevalence, the clinical efficacy of regimens used by physicians is of interest. This study aims to examine treatment outcom...
作者:Dalla Costa Elis , Ribeiro Marta , Silva Márcia ...
来源:[J].BMC Microbiology(IF 3.104), 2009, Vol.9 (1), pp.39DOAJ
摘要:... A few studies with limited sample sizes have separately evaluated mutations in kat G, ahp C and inh A genes that are associated with isoniazid (INH) resistance. Increasing prevalence of INH resistance, especially in high tuberculosis (TB) prevalent countries is worsening th...
作者:Gaurava Srivastava , Shubhandra Tripathi , Akhil Kumar ...
来源:[J].Tuberculosis(IF 3.033), 2017, Vol.105, pp.18-27Elsevier
摘要:... Resistance against Isoniazid (INH), targeting MtKatG protein, is one of the most commonly occurring resistances in MDR TB strains. S315T-MtKatG mutation is widely reported for INH resistance. Despite having knowledge about the mechanism of INH, exact binding site of INH to M...
作者:Anika Mann , Thomas Pelz , Knut Rennert ...
来源:[J].Human Cell(IF 1.409), 2017, Vol.30 (4), pp.267-278Springer
摘要:... A prototypic substance is the anti-tuberculosis agent INH, which is metabolized into N -acetylhydrazine, which then triggers hepatotoxicity. Therefore, the aim of the present study was to test if this effect can also be detected in HepaRG cells and if it can be counteract...
作者:Azar Dokht Khosravi , Hamed Goodarzi , Seyed Mohammad Alavi
来源:[J].Brazilian Journal of Infectious Diseases(IF 1.036), 2012, Vol.16 (1), pp.57-62Elsevier
摘要:Abstract(#br)Objective(#br)Isoniazid (INH) and rifampin (RIF) are the most effective first line antibiotics against Mycobacterium tuberculosis . Mutations in several genes determine resistance of M. tuberculosis to INH, with the most common gene target of kat G, and resistance to...
作者:T. Li , A.T. Ma , Y.J. Zhang ...
来源:[J].Small Ruminant Research(IF 1.124), 2017, Vol.157, pp.23-26Elsevier
摘要:Abstract(#br)The aim of the study was to investigate the effects of silencing the inhibin α-subunit (INHα) gene by RNAi on the mRNA levels of steroidogenic acute regulatory protein (StAR), follistatin (FST), inhibin β-subunit (INHβB), and FSH receptor (FSHR) in cultured shee...
作者:Ruiz P , Causse M , Vaquero M ...
来源:[J].Infection and Drug Resistance, 2017, Vol.Volume 10, pp.463-467DOAJ
摘要:... 2Microbiology Laboratory, Reina Sofía University Hospital, Córdoba, Spain Abstract: A new automated real-time PCR assay for the detection of rifampicin (RIF) and isoniazid (INH) resistance in Mycobacterium tuberculosis (MTB) was evaluated. A total of 163 clinical samples...
作者:Kingsley King-Gee Tam , Kenneth Siu-Sing Leung , Sabrina Wai-Chi To ...
来源:[J].Diagnostic Microbiology & Infectious Disease(IF 2.26), 2017Elsevier
摘要:Abstract(#br)Abbott RealTi m e MTB (Abbott-RT) in conjunction with Abbott RealTi m e MTB RIF/INH Resistance (Abbott-RIF/INH) is a new, high-throughput automated nucleic acid amplification platform (Abbott-MDR) for detection of Mycobacterium tuberculosis complex (MTBC) and the g...
作者:Ishwari Kadariya , Jiaxing Wang , Zia ur Rehman ...
来源:[J].Journal of Steroid Biochemistry and Molecular Biology(IF 3.984), 2015, Vol.152, pp.161-170Elsevier
摘要:Abstract(#br)Inhibin α (INHα), a member of TGFβ superfamily, is an important modulator of reproductive function that plays a vital role in follicular changes, cell differentiation, oocyte development, and ultimately in mammalian reproduction. However, the role of inhibin ...
作者:Li M. Fu , Thomas M. Shinnick
来源:[J].Tuberculosis(IF 3.033), 2006, Vol.87 (1), pp.63-70Elsevier
摘要:... Isoniazid (INH) is a first-line drug for the treatment of tuberculosis and the microarray approach has generated new insight into the action of INH on a drug-susceptible strain. It has also shown that INH does not induce any significant change in gene expression when applied ...

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