全部文献期刊会议图书|学者科研项目
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作者:Yong Qian , Xiaosong Zhong , Daniel C Flynn ...
来源:[J].Oncogene(IF 7.357), 2005, Vol.24 (19), pp.3154-3165
摘要:... Integrin-linked kinase (ILK) is a cytoplasmic effector of integrin receptors. ILK is known to be involved in multiple cellular functions. However, the signaling pathways involved in ILK-mediated cellular structure and motility remain to be elucidated. Here, we have demonstra...
作者:Ashu S Kumar , Izabela Naruszewicz , Ping Wang ...
来源:[J].Oncogene(IF 7.357), 2004, Vol.23 (19), pp.3454-3461
摘要:Abstract(#br)ILKAP is a protein phosphatase 2C that selectively associates with integrin linked kinase, ILK, to modulate cell adhesion and growth factor signaling. We investigated the role of endogenous cellular ILKAP in antagonizing ILK signaling of two key targets, PKB and G...
作者:Wenhui Yang , Yan He , Lulu Gan ...
来源:[J].Scientific Reports(IF 2.927), 2018, Vol.8 (1), pp.1503-1516
摘要:... And integrin linked kinase (ILK) may be a key factor contributed to arteriogenesis of coronary micrangium during CSWT. In conclusion, non-invasive cardiac shock wave could promote arteriogenesis of coronary micrangium and alleviate myocardial apoptosis and fibrosis after...
作者:I Serrano , P C McDonald , F E Lock ...
来源:[J].Oncogene(IF 7.357), 2013, Vol.32 (1), pp.50-60
摘要:... Integrin-linked kinase (ILK) is a focal adhesion adaptor and a serine/threonine protein kinase that regulates cell proliferation, survival and EMT. Elucidating the molecular mechanisms necessary for development and progression of human malignancies is critical to predict ...
作者:Séverine Cruet-Hennequart , Sylvie Maubant , José Luis ...
来源:[J].Oncogene(IF 7.357), 2003, Vol.22 (11), pp.1688-1702
摘要:... We found that α v integrins regulate cell proliferation through activation of integrin-linked kinase (ILK). An anti- α v-blocking antibody specifically inhibits the growth of IGROV1 and SKOV-3. The inhibition of cell proliferation involves α v<...
作者:Anthony Marotta , Clara Tan , Virginia Gray ...
来源:[J].Oncogene(IF 7.357), 2001, Vol.20 (43), pp.6250-6257
摘要:... Intriguingly, overexpression of the integrin-linked kinase (ILK) has been shown to modulate β-catenin subcellular localization and function. However, the significance of this finding for human carcinogenesis remains unclear. Here, we report the increased biochemical activi...
作者:Donald E White , Robert D Cardiff , Shoukat Dedhar ...
来源:[J].Oncogene(IF 7.357), 2001, Vol.20 (48), pp.7064-7072
摘要:Abstract(#br)The integrin linked kinase (ILK) is a cytoplasmic effector of integrin receptors, involved in the regulation of integrin binding properties as well as the activation of cell survival and proliferative pathways, including those involving MAP kinase, PKB/Akt and GSK-3...
作者:Bin Zeng , Lei Liu , Shaofeng Wang ...
来源:[J].Acta Histochemica(IF 1.608), 2017, Vol.119 (4), pp.400-406
摘要:... ILK has been reported to be an important factor regulating apoptosis and angiogenesis. This study examined the role and mechanism of ILK in MSCs survival and angiogenesis. In hypoxic condition, upregulation of ILK expression increased the phosphorylation of Akt and mTOR, resu...
作者:Shao-Chun Wang , Keishi Makino , Weiya Xia ...
来源:[J].Oncogene(IF 7.357), 2001, Vol.20 (47), pp.6960-6964
摘要:... This event was associated with the down-regulation of the integrin-linked kinase (ILK) activity. Since ILK is a key factor in regulating the cellular signaling in responding to the extracellular signals through adhesion molecules like integrins, our results indicate that DOC-...
作者:J Kalra , B W Sutherland , A L Stratford ...
来源:[J].Oncogene(IF 7.357), 2010, Vol.29 (48), pp.6343-6356
摘要:Abstract(#br)In a previous study it was found that the therapeutic effects of QLT0267, a small molecule inhibitor of integrin-linked kinase (ILK), were influenced by Her2/ neu expression. To understand how inhibition or silencing of ILK influences Her2/ neu expression, Her2/ ...

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