全部文献期刊会议图书|学者科研项目
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作者:Liu C , Chen W , Chen Z ...
来源:[J].OncoTargets and Therapy(IF 2.073), 2019, Vol.Volume 12, pp.4655-4663DOAJ
摘要:... 8Cleft Lip and Palate Treatment Center, The Second Affliated Hospital, Shantou University Medical College, Shantou, Guangdong, 515041, People’s Republic of ChinaBackground: IMD-0354 is a kind of hydrophobic small molecule inhibitor of IKKΒ, which can effectively inhib...
作者:Marcela Cataldi , Nirav R. Shah , Sébastien A. Felt ...
来源:[J].Virology(IF 3.367), 2015, Vol.485, pp.340-354Elsevier
摘要:... To better understand the mechanism of resistance, we tested a panel of 16 small molecule inhibitors of different cellular signaling pathways, and identified TPCA-1 (IKKinhibitor) and ruxolitinib (JAK1/2 inhibitor), as strong enhancers of VSV-ΔM51 replication and viru...
作者:S.M. Lunin , M.O. Khrenov , T.V. Novoselova ...
来源:[J].International Immunopharmacology(IF 2.417), 2015, Vol.25 (2), pp.260-266Elsevier
摘要:Abstract(#br)To investigate some cellular and molecular aspects of the autoimmune response and anti-inflammatory efficiency of potential therapeutic agents in a severe form of experimental autoimmune encephalomyelitis (sEAE), an inhibitor of NF-kappaB signalling, IKK Inhibitor XI...
作者:Man Liu , Cheng‐qian Xiao , Ming‐wei Sun ...
来源:[J].Journal of Cellular and Molecular Medicine(IF 4.753), 2019, Vol.23 (6), pp.4301-4312Wiley
摘要:... as a potent inhibitor of both STAT3 and NF‐κB signalling pathways. Our data demonstrated that xanthatin was a covalent inhibitor and its activities depended on its α‐methylene‐γ‐butyrolactone group. It preferentially interacted with the Cys243 of JAK2 and the Cys...
作者:E. G. Novoselova , M. O. Khrenov , O. V. Glushkova ...
来源:[J].Mediators of Inflammation(IF 3.882), 2014, Vol.2014Hindawi
摘要:The present study was designed to compare the anti-inflammatory effects of several agents applied in vivo , namely, a synthetic inhibitor of the NF- κ B cascade, fat-soluble antioxidants, and the thymic peptide thymulin. Cytokine response in LPS-treated mice was analysed in ta...
作者:Glushkova , Parfenyuk , Khrenov ...
来源:[J].Journal of Immunotoxicology(IF 1.571), 2013, Vol.10 (2), pp.133-140Taylor & Francis
摘要:... Three inhibitors of TLR4, SAPK/JNK, and NF- κ B signaling, namely CLI-095, SP600125, and IKK Inhibitor XII, respectively, were added to cultured RAW 264.7 macrophages before the Escherichia coli lipopolysaccharide (LPS) application. Treatments of RAW 264.7 cells with each...
作者:Andrew J. Varble , Christopher D. Ried , Warren J. Hammond ...
来源:[J].Virology(IF 3.367), 2016, Vol.499, pp.99-104Elsevier
摘要:... Addition of an IκB kinase (IKK) inhibitor blocked NF-κB activation and interferon-β mRNA expression in cells infected with viruses encoding the M51R mutation in M. These results indicate that the VSV M protein inhibits activation of NF-κB by targeting an event upstream o...
作者:Rikuta Hamaya , Masahito Ogawa , Naho Kobayashi ...
来源:[J].International Heart Journal(IF 1.233), 2012, Vol.53 (2), pp.133-138J-STAGE
摘要:Japan's largest platform for academic e-journals: J-STAGE is a full text database for reviewed academic papers published by Japanese societies
作者:Hao Ping , Feiya Yang , Mingshuai Wang ...
来源:[J].Oncology Reports(IF 2.297), 2016, Vol.36 (3), pp.1658-1664Spandidos
摘要:IκB kinase (IKK)/nuclear factor κB (NF-κB) pathway activation is a key eventin the acquisition of invasive and metastatic capacities in prostate cancer. Apotent small-molecule compound, BMS-345541, was identified as a highly selectiveIKKα and IKKβ inhibitor to inhibit kin...

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