全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Yu DP , Zhang C , Gui JQ
来源:[J].OncoTargets and Therapy(IF 2.073), 2017, Vol.Volume 10, pp.2609-2619DOAJ
摘要:Dapeng Yu,1,* Chao Zhang,2,* Junqing Gui2 1Department of Urinary Surgery, the Jining No 1 People’s Hospital, Jining, 2Department of Urinary Surgery, the Qujing No 1 People’s Hospital, Qujing, People’s Republic of China *These authors contributed equally to this work Abstract: The elevated expressions of RNA-binding protein HuR...
作者:Ting Wu , Jia-Xin Shi , Shen Geng ...
来源:[J].BMC Pulmonary Medicine(IF 2.76), 2016, Vol.16 (1)Springer
摘要:... Here, we show that human antigen R (HuR), an RNA binding protein which binds preferentially to AU-rich elements (AREs) and stabilizes mRNAs, regulates TNF-α-induced ICAM-1 expression in the MK2/HuR signaling pathway.(#br) Method(#br)MK2 and HuR were silenced respectively in...
作者:WenGong Wang
来源:[J].Science China Life Sciences(IF 2.024), 2014, Vol.57 (8), pp.863-866Springer
摘要:Abstract(#br)HuR (ELAV11 (embryonic lethal, abnormal vision)-like 1), a ubiquitously expressed member of the ELAV-like RNA-binding protein family, has been shown to regulate the stability and translation of mRNAs that encode factors regulating cellular senescence, thereby imp...
作者:Liang Peir-In , Li Wei-Ming , Wang Yu-Hui ...
来源:[J].BMC Cancer(IF 3.333), 2012, Vol.12 (1)DOAJ
摘要:Abstract Background HuR is an RNA-binding protein that post-transcriptionally modulates the expressions of various target genes implicated in carcinogenesis, such as CCNA2 encoding cyclin A. No prior study attempted to evaluate the significance of HuR expression in a large cohort...
作者:Xun Guo , Melanie C. Connick , Jennifer Vanderhoof ...
来源:[J].International Journal of Molecular Sciences(IF 2.464), 2015, Vol.16 (4), pp.7112-7132DOAJ
摘要:... Here, we show that in breast cancer cells, cyclin E1 upregulation by the RBP HuR is through specific binding to regions in the cyclin E1 mRNA 3' untranslated region (3'UTR) containing U-rich elements. Similarly, miR-16 represses cyclin E1, dependent on its cognate binding si...
作者:Jun Guo , Meng Li , Xiangyu Meng ...
来源:[J].Cellular Physiology and Biochemistry(IF 3.415), 2014, Vol.33 (3), pp.810-822DOAJ
摘要:... Using computational miRNA target prediction databases, HuR was predicted as a target of miR-291b-3p. Luciferase assay, immunofluorescence and western blot were used to further explore the effects of miR-291b-3p on HuR expression. In addition, the effect of HuR on cell apopto...
作者:Łukasz Piotr Fus , Paweł Pihowicz , Łukasz Koperski ...
来源:[J].Annals of Diagnostic Pathology(IF 0.975), 2018, Vol.33, pp.40-44Elsevier
摘要:Abstract(#br)Purpose(#br)HuR (human antigen R) protein is a RNA binding protein that stabilizes the mRNA and controls the translation of genes involved in cell proliferation, differentiation, and carcinogenesis. Overexpression of HuR was reported in a variety of cancers, howeve...
作者:Ye Dao Xiong , Lu Xing Rong , Chi Pan
来源:[J].Journal of Gastrointestinal Surgery(IF 2.361), 2017, Vol.21 (2), pp.389-397Springer
摘要:Abstract(#br) Objectives(#br)The objective of the present study is to explore the effect of lentivirus-mediated HuR interference on the development and progression of postoperative ileus and the role of HuR in the regulation of the p38/MAPK-activated protein kinase-2 (MK2) signal...
作者:Latorre Elisa , Tebaldi Toma , Viero Gabriella ...
来源:[J].Molecular Cancer(IF 5.134), 2012, Vol.11 (1)DOAJ
摘要:Abstract Background HuR, an RNA binding protein involved in the post-transcriptional regulation of a wide spectrum of mRNAs, has been demonstrated to be a determinant of carcinogenesis and tumor aggressiveness in several cancer types. In this study, we investigated the role of HuR...
作者:Ahn Jinwoo , Byeon In-Ja , Dharmasena Sanjeewa ...
来源:[J].Retrovirology(IF 5.657), 2010, Vol.7 (1), pp.40DOAJ
摘要:Abstract Background Lemay et al recently reported that the RNA binding protein HuR directly interacts with the ribonuclease H (RNase H) domain of HIV-1 reverse transcriptase (RT) and influences the efficiency of viral reverse transcription (Lemay et al ., 2008, Retrovirology 5:47...

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