全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Yu DP , Zhang C , Gui JQ
来源:[J].OncoTargets and Therapy(IF 2.073), 2017, Vol.Volume 10, pp.2609-2619DOAJ
摘要:Dapeng Yu,1,* Chao Zhang,2,* Junqing Gui2 1Department of Urinary Surgery, the Jining No 1 People’s Hospital, Jining, 2Department of Urinary Surgery, the Qujing No 1 People’s Hospital, Qujing, People’s Republic of China *These authors contributed equally to this work Abstract: The elevated expressions of RNA-binding protein HuR...
作者:Ting Wu , Jia-Xin Shi , Shen Geng ...
来源:[J].BMC Pulmonary Medicine(IF 2.76), 2016, Vol.16 (1)Springer
摘要:... Here, we show that human antigen R (HuR), an RNA binding protein which binds preferentially to AU-rich elements (AREs) and stabilizes mRNAs, regulates TNF-α-induced ICAM-1 expression in the MK2/HuR signaling pathway.(#br) Method(#br)MK2 and HuR were silenced respectively in...
作者:WenGong Wang
来源:[J].Science China Life Sciences(IF 2.024), 2014, Vol.57 (8), pp.863-866Springer
摘要:Abstract(#br)HuR (ELAV11 (embryonic lethal, abnormal vision)-like 1), a ubiquitously expressed member of the ELAV-like RNA-binding protein family, has been shown to regulate the stability and translation of mRNAs that encode factors regulating cellular senescence, thereby imp...
作者:Cheng-Zhi Xu , Chenyan Jiang , Qingwei Wu ...
来源:[J].Cellular Physiology and Biochemistry(IF 3.415), 2016, Vol.40 (5), pp.1039-1051DOAJ
摘要:... HuR is also overexpressed during tumourigenesis and is abnormally present within the cytoplasm, where it binds to AU-rich elements in the 3′UTRs of target mRNA and post-transcriptionally regulates the expression of its target genes. However, whether HOTAIR is regulated and...
作者:Liang Peir-In , Li Wei-Ming , Wang Yu-Hui ...
来源:[J].BMC Cancer(IF 3.333), 2012, Vol.12 (1)DOAJ
摘要:Abstract Background HuR is an RNA-binding protein that post-transcriptionally modulates the expressions of various target genes implicated in carcinogenesis, such as CCNA2 encoding cyclin A. No prior study attempted to evaluate the significance of HuR expression in a large cohort...
作者:Xun Guo , Melanie C. Connick , Jennifer Vanderhoof ...
来源:[J].International Journal of Molecular Sciences(IF 2.464), 2015, Vol.16 (4), pp.7112-7132DOAJ
摘要:... Here, we show that in breast cancer cells, cyclin E1 upregulation by the RBP HuR is through specific binding to regions in the cyclin E1 mRNA 3' untranslated region (3'UTR) containing U-rich elements. Similarly, miR-16 represses cyclin E1, dependent on its cognate binding si...
作者:Jun Guo , Meng Li , Xiangyu Meng ...
来源:[J].Cellular Physiology and Biochemistry(IF 3.415), 2014, Vol.33 (3), pp.810-822DOAJ
摘要:... Using computational miRNA target prediction databases, HuR was predicted as a target of miR-291b-3p. Luciferase assay, immunofluorescence and western blot were used to further explore the effects of miR-291b-3p on HuR expression. In addition, the effect of HuR on cell apopto...
作者:Suman Govindaraju , Beth S. Lee
来源:[J].Cellular Physiology and Biochemistry(IF 3.415), 2014, Vol.34 (2), pp.519-532DOAJ
摘要:Background/Aims: HuR is an RNA-binding protein that regulates the post-transcriptional life of thousands of cellular mRNAs and promotes cell survival. HuR is expressed as two mRNA transcripts that are differentially regulated by cell stress. The goal of this study is to define f...
作者:Łukasz Piotr Fus , Paweł Pihowicz , Łukasz Koperski ...
来源:[J].Annals of Diagnostic Pathology(IF 0.975), 2018, Vol.33, pp.40-44Elsevier
摘要:Abstract(#br)Purpose(#br)HuR (human antigen R) protein is a RNA binding protein that stabilizes the mRNA and controls the translation of genes involved in cell proliferation, differentiation, and carcinogenesis. Overexpression of HuR was reported in a variety of cancers, howeve...
作者:Ye Dao Xiong , Lu Xing Rong , Chi Pan
来源:[J].Journal of Gastrointestinal Surgery(IF 2.361), 2017, Vol.21 (2), pp.389-397Springer
摘要:Abstract(#br) Objectives(#br)The objective of the present study is to explore the effect of lentivirus-mediated HuR interference on the development and progression of postoperative ileus and the role of HuR in the regulation of the p38/MAPK-activated protein kinase-2 (MK2) signal...

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