全部文献期刊会议图书|学者科研项目
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作者:Kaustav Das Gupta , Melanie R. Shakespear , James E.B. Curson ...
来源:[J].Cell Reports, 2020, Vol.30 (8), pp.2712-2728.e8
摘要:Summary(#br)Histone deacetylases (HDACs) drive innate immune cell-mediated inflammation. Here we identify class IIa HDACs as key molecular links between Toll-like receptor (TLR)-inducible aerobic glycolysis and macrophage inflammatory responses. A proteomic screen identified the ...
作者:Yodita Asfaha , Christian Schrenk , Leandro A. Alves Avelar ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2019, Vol.27 (22)
摘要:... An essential post-translational modification is the histone acetylation/deacetylation-process which is regulated by histone acetyltransferases (HATs) and histone deacetylases (HDACs). The mammalian zinc dependent HDAC family is subdivided into three classes: class I (HDACs 1-...
作者:Mu-Hui Wang , Cheng-Han Wu , Ting-Yu Huang ...
来源:[J].Developmental Biology(IF 3.868), 2019, Vol.449 (2), pp.122-131
摘要:... Histone deacetylases (HDACs) have been shown to play roles in the regeneration of amphibian tails and limbs. In this study, a bi-phasic up-regulation of HDAC1 was noted before early differentiation stage of axolotl limb regeneration. Limb regeneration was delayed in larvae in...
作者:Pei-Jie Chen , Cheng Huang , Xiao-Ming Meng ...
来源:[J].Biochimie(IF 3.142), 2015, Vol.116, pp.61-69
摘要:... Reversible deacetylation of histone proteins is one of the most abundant epigenetic modifications and is crucial in modulating gene expression. Recent evidence has highlighted a pathological imbalance between the acetylation and deacetylation of histone proteins regulated by ...
作者:Jelena Melesina , Dina Robaa , Raymond J. Pierce ...
来源:[J].Journal of Molecular Graphics and Modelling(IF 2.325), 2015, Vol.62, pp.342-361
摘要:Abstract(#br)Histone deacetylases (HDACs) are promising epigenetic targets for the treatment of various diseases, including cancer and neurodegenerative disorders. There is evidence that they can also be addressed to treat parasitic infections. Recently, the first X-ray structure...
作者:Marcus Freitag , Jörg Schemies , Tim Larsen ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2011, Vol.19 (12), pp.3669-3677
摘要:... Specifically, drugs that interfere with histone deacetylation could be useful to induce differentiation, growth arrest as well as apoptotic cell death in tumor cells. One class of histone deacetylases is known as sirtuins some of which ( Saccharomyces cerevisiae Sir2) are for...
作者:Christopher J. Millard , Peter J. Watson , Louise Fairall ...
来源:[J].Trends in Pharmacological Sciences(IF 9.25), 2017, Vol.38 (4), pp.363-377
摘要:Histone deacetylase (HDAC) inhibitors are proven anticancer therapeutics and have potential in the treatment of many other diseases including HIV infection, Alzheimer’s disease, and Friedreich’s ataxia. A problem with the currently available HDAC inhibitors is that they h...
作者:Di Zhang , Yao Wang , Hai-Yue Zhang ...
来源:[J].Life Sciences(IF 2.555), 2019, Vol.223, pp.1-8
摘要:... The changes of HDAC2, HDAC6, AH3 and histone H3 levels in normal control and 4 CHB patient liver tissue samples before and after antiviral treatment were examined. The HDAC inhibitor, TSA, anti-HBV agents, ETV and IFN-α were used to stimulate HepG2.2.15 cells. The levels of...
作者:Michelle Lima Garcez , Carlos Alberto de Carvalho , Francielle Mina ...
来源:[J].Experimental Gerontology(IF 3.911), 2018
摘要:... Included amongst these alterations is histone acetylation, which may play a crucial role in aging. Thus, the aims of the present study were to standardize the animal model of d -gal, and to evaluate the effects caused by sodium butyrate (SB), which is a histone deacetylase in...

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