全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Joanna Jaworska , Malgorzata Ziemka-Nalecz , Joanna Sypecka ...
来源:[J].Journal of Neuroinflammation(IF 4.351), 2017, Vol.14 (1)Springer
摘要:Histone deacetylase inhibitor (HDACi), sodium butyrate (SB), has been shown to be neuroprotective in adult brain injury models. Potential explanation for the inhibitor action involves among others reduced inflammation. We therefore anticipated that SB will provide a suitable opti...
作者:Wen-Pyng Wu , Yi-Giien Tsai , Tze-Yi Lin ...
来源:[J].BMC Nephrology(IF 1.644), 2017, Vol.18 (1)Springer
摘要:The histone deacetylase (HDAC) inhibitor, which has potential effects on epigenetic modifications, had been reported to attenuate renal fibrosis. CD4+ forkhead box P3 (FOXP3)+ T regulatory (Treg) cells may be converted to inflammation-associated T helper 17 ...
作者:Sridhar Murahari , Aimee L. Jalkanen , Samuel K. Kulp ...
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:... Histone deacetylase (HDAC) inhibitors are a promising new class of anticancer agents. In this study, we investigated the activity of the novel HDAC inhibitor AR-42 in a panel of human and canine OS cell lines.
作者:K C Lakshmaiah , Linu A Jacob , S Aparna ...
来源:[J].Journal of Cancer Research and Therapeutics(IF 0.761), 2014, Vol.10 (3), pp.469-478DOAJ
摘要:... Three interlinked epigenetic processes regulate gene expression at the level of chromatin, namely DNA methylation, nucleosomal remodeling and histone covalent modifications. Post-translational modifications that occur on certain amino acid residues of the tails of histone pro...
作者:Liping Li , Youxiang Sun , Jiangqin Liu ...
来源:[J].BMC Biochemistry(IF 1.776), 2015, Vol.16 (1)Springer
摘要:Abstract(#br) Background(#br)Histone deacetylase inhibitors (HDACi’s) are emerging as promising anticancer drugs alone or in combination with chemotherapy or radiotherapy agents. Previous research suggests that HDACi’s have a high degree of selectivity for killing cancer c...
作者:María Díaz-Núñez , Alejandro Díez-Torre , Olivier De Wever ...
来源:[J].BMC Cancer(IF 3.333), 2016, Vol.16 (1)Springer
摘要:Abstract(#br) Background(#br)Histone deacetylase inhibitors (HDACi) exert multiple cytotoxic actions on cancer cells. Currently, different synthetic HDACi are in clinical use or clinical trials; nevertheless, since both pro-invasive and anti-invasive activities have been describe...
作者:Yu-Wei Chou , Fen-Fen Lin , Sakthivel Muniyan ...
来源:[J].Cell & Bioscience(IF 3), 2015, Vol.5 (1)Springer
摘要:...(#br) Method(#br)Histone deacetylase (HDAC) inhibitors were examined to determine their effects in androgen receptor (AR)/cellular prostatic acid phosphatase (cPAcP)-positive PCa cells, including LNCaP C-33, C-81, C4-2 and C4-2B and MDA PCa2b androgen-sensitive and androgen-in...
作者:Conrad V. Simoben , Dina Robaa , Alokta Chakrabarti ...
来源:[J].Molecules(IF 2.428), 2018, Vol.23 (3)DOAJ
摘要:... In the present study, a docking based virtual screening procedure using the crystal structure of histone deacetylase 8 from Schistosoma mansoni (smHDAC8) was designed. From the developed screening protocol, we were able to identify eight novel N-(2,5-dioxopyrrolidin-3-yl...
作者:Ki Cheong Park , Jun Hyeok Heo , Jeong Yong Jeon ...
来源:[J].BMC Cancer(IF 3.333), 2015, Vol.15 (1)Springer
摘要:... Inappropriate histone modifications can result in dysregulation of cell growth, leading to neoplastic transformation and cell death. Renal tumors have been shown to have a higher global methylation percentage and reduced histone acetylation. Preclinical models have revealed t...
作者:Constantinos Giaginis , Christos Damaskos , Ioannis Koutsounas ...
来源:[J].BMC Gastroenterology(IF 2.11), 2015, Vol.15 (1)Springer
摘要:Abstract(#br) Background(#br)Histone deacetylases (HDACs) have been associated with malignant tumor development and progression in humans. HDAC inhibitors (HDACIs) are currently being explored as anti-cancer agents in clinical trials. The present study aimed to evaluate the ...

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