全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Samapika Routray , Aparajita Sunkavalli , Niharika Swain ...
来源:[J].Journal of Cancer Research and Therapeutics(IF 0.761), 2013, Vol.9 (4), pp.583-586DOAJ
摘要:Heat shock protein 90 (Hsp90) a member of the heat shock proteins (HSPs) family, is an adenosine triphosphate dependent molecular chaperone protein, which integrates multiple oncogenic pathways. Clinically, encouraging results have been demonstrated in melanoma, acute myeloid leu...
作者:Nai-Jung Chiang , Sheng-Nan Wu , Li-Tzong Chen
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2015, Vol.127 (4), pp.404-413Elsevier
摘要:Abstract(#br)NVP-AUY922 (AUY) is a potent inhibitor of heat shock protein 90 (HSP90). Whether this compound can exert additional effects on membrane ion channels remains elusive. We investigated the effect of AUY on ion currents in human pancreatic duct epithelial cells (PDECs)...
作者:Hiroki Murano , Takumi Matsubara , Ikuo Takahashi ...
来源:[J].Plant Biotechnology Reports(IF 1.051), 2017, Vol.11 (2), pp.107-113Springer
摘要:Geldanamycin is a macrocyclic heat shock protein 90 (HSP90) inhibitor that suppresses cancer cell proliferation. Since geldanamycin also promotes the heat shock response (HSR) in cells, this compound is used as a chemical inducer of the HSR in Arabidopsis . Although many types of...
作者:Hang-ming Dong , Yan-qing Le , Yan-hong Wang ...
来源:[J].Respiratory Research(IF 3.642), 2017, Vol.18 (1)Springer
摘要:... Heat shock protein (Hsp) 90α is also implicated in the lung endothelial barrier dysfunction by disrupting RhoA signaling. However, the effect of extracellular Hsp90α (eHsp90α) on the bronchial epithelial barrier disruption induced by HDM has never been reported.
作者:Kun Li , Yamei Xue , Aijun Chen ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (12)DOAJ
摘要:Heat shock protein 90 plays critical roles in client protein maturation, signal transduction, protein folding and degradation, and morphological evolution; however, its function in human sperm is not fully understood. Therefore, our objective in this study was to elucidate the me...
作者:Shu Miao-An , Tu Dan-Dan , Zhang Pan ...
来源:[J].Fisheries Science(IF 0.897), 2017, Vol.83 (2), pp.251-258Springer
摘要:Heat shock protein 90 (HSP90) is a highly conserved molecular chaperone that plays important roles in modulating multiple cellular stress responses. In this study, full-length complementary DNA of hsp90 from the giant spiny frog Quasipaa spinosa ( Qs) was first isolated and de...
作者:Masato Kakeda , Michel Arock , Christoph Schlapbach ...
来源:[J].Journal of the American Academy of Dermatology(IF 4.906), 2014, Vol.70 (4), pp.683-690.e1Elsevier
摘要:... Heat shock protein (HSP) 90 plays an important role in cell survival; cytokine signaling, such as interleukin-17 receptor signaling; and immune responses.(#br)Objective(#br)We sought to elucidate protein expression and distribution of HSP90 in psoriasis.(#br)Methods(#br)HSP90...
作者:A. V. Snigireva , V. V. Vrublevskaya , Yu. Yu. Skarga ...
来源:[J].Bulletin of Experimental Biology and Medicine(IF 0.341), 2014, Vol.157 (4), pp.476-478Springer
摘要:We studied the effect of purifi ed native heat shock protein 90 (Hsp90) from bovine and mouse brain on migration and invasion of human glioblastoma (A-172) and fi brosarcoma (HT1080) cells. Hsp90 in concentrations of 0.01-0.10 mg/ml stimulated migration and invasion of tumor cell...
作者:Sae Bin Lee , A-ram Lim , Dong Kyun Rah ...
来源:[J].Tissue and Cell(IF 1.038), 2016Elsevier
摘要:Abstract(#br)Heat shock protein 90 is a chaperone molecule that aids in proper folding of target proteins. Recently, heat shock protein 90 was found to play a role in would healing through regulation of fibroblast functions. The aim of the present study was to investigate the r...
作者:Walid L. Shaib , Ganji Purnachandra Nagaraju , Batoul Farran ...
来源:[J].Process Biochemistry(IF 2.414), 2019Elsevier
摘要:... HIF-1α and STAT-3 represent clients of heat shock protein 90 (HSP90). We hypothesize that HSP90 inhibition can impair STAT-3 and HIF-1α activation, resulting in reduced VEGF expression in colorectal cancer (CRC). Protein levels and mRNA levels were measured using wester...

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