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作者:Malini Raghavan , Brogan Yarzabek , Anita J. Zaitouna ...
来源:[J].Human Immunology(IF 2.298), 2019, Vol.80 (4), pp.221-227
摘要:Abstract(#br)HLA class I molecules are highly polymorphic cell surface proteins that trigger immune responses by CD8 + T cells and natural killer (NK) cells. Most humans express six different HLA class I proteins encoded by the HLA-A, HLA-B and HLA-C genes. HLA class I molecules ...
作者:Cornelis J. M. Melief , Jan H. Kessler
来源:[J].Genome Medicine(IF 3.397), 2017, Vol.9 (1)
摘要:Advances in mass spectrometry have allowed the high-throughput quantitative identification of human leukocyte antigen (HLA) class I ligands, and recent studies have reported on the breadth and diversity of the HLA class I immunopeptidome. These findings have far-reaching implicat...
作者:Marcelo V. Negrao , Vincent K. Lam , Alexandre Reuben ...
来源:[J].Journal of Thoracic Oncology(IF 4.473), 2019, Vol.14 (6), pp.1021-1031
摘要:... Recent studies showed that human leukocyte antigen ( HLA ) class I heterozygosity might be important in mediating benefit from ICB. We aimed to investigate the impact of HLA class I genotype on outcomes of patients with NSCLC treated with ICB.(#br)Methods(#br)We collected HLA...
作者:Kimberley Jones , Leesa Wockner , Alycia Thornton ...
来源:[J].Transplant Immunology(IF 1.52), 2015, Vol.32 (2), pp.126-130
摘要:... Interestingly, several studies have reported HLA class I alleles with protective or susceptibility associations. However, results are conflicting, likely influenced by methodology including inconsistent use of multiple hypothesis testing. By contrast, HLA class I associati...
作者:Fernando Concha-Benavente , Raghvendra Srivastava , Soldano Ferrone ...
来源:[J].Oral Oncology(IF 2.695), 2016, Vol.58, pp.52-58
摘要:... One is represented by the downregulation of tumor antigen (TA) processing and presentation because of abnormalities in the HLA class I antigen processing machinery (APM). The other one is represented by the anergy of effector immune infiltrates in the tumor microenvironment c...
作者:Simon Rothenfusser , Armin Buchwald , Sylvia Kock ...
来源:[J].Cellular Immunology(IF 1.743), 2002, Vol.215 (1), pp.32-44
摘要:... Most cytotoxic human Vγ9/Vδ2 T cells express inhibitory natural killer cell receptors for HLA class I that downmodulate the responses of the γδ T lymphocytes against HLA class I expressing cells. In this study we show that transfection of the human β 2 -microglobulin...
作者:Dan Ou , Julien Adam , Ingrid Garberis ...
来源:[J].Radiotherapy and Oncology(IF 4.52), 2018
摘要:Abstract(#br)Background and purpose(#br)To investigate the prognostic value of tumor-associated macrophages (TAM) and HLA class I expression according to HPV status in patients with head and neck squamous cell carcinoma treated with definitive radiotherapy combining cisplatin (C...
作者:Juergen Bukur , Simon Jasinski , Barbara Seliger
来源:[J].Seminars in Cancer Biology(IF 7.436), 2012, Vol.22 (4), pp.350-358
摘要:Abstract(#br)In human tumors alterations in the surface expression and/or function of the major histocompatibility complex (MHC) class I antigens are frequently found and equip neoplastic cells with mechanisms to escape immune control. The aberrant expression of HLA class I molec...
作者:Alberto Chersi , Laura Rosano , Nobuyuki Tanigaki
来源:[J].Human Immunology(IF 2.298), 2000, Vol.61 (12), pp.1298-1306
摘要:Abstract(#br)Protein-reactive, conformation-independent anti-peptide antibodies were raised in rabbits against a C-terminal sequence SDSAQGSDVSLA, common to most HLA-A and -B locus products. Antibodies were coupled to 4.5-μm polystyrene beads through the Fc portion by the us...
作者:Hiro Sato , Yoshiyuki Suzuki , Munenori Ide ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.9 (9)
摘要:OBJECTIVE: Enhancing immunologic responses, including human leukocyte antigen (HLA) class I expression on tumor cells and recognition and elimination of tumor cells by tumor-specific cytotoxic T lymphocyte (CTL), is considered a novel concept of radiotherapy. The present study ex...

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