全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Soichiro Ide , Yuiko Ikekubo , Masayoshi Mishina ...
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2017, Vol.135 (3), pp.138-140Elsevier
摘要:Abstract(#br)We investigated the rapid and sustained antidepressant effects of enantiomers of ketamine in N -methyl- d -aspartate (NMDA) receptor GluN2D subunit knockout (GluN2D-KO) mice. Intraperitoneal administration of ketamine or its enantiomers 10 min before the tail-suspens...
作者:Soichiro Ide , Yuiko Ikekubo , Masayoshi Mishina ...
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2017, Vol.135 (3), pp.138-140DOAJ
摘要:We investigated the rapid and sustained antidepressant effects of enantiomers of ketamine in N-methyl-d-aspartate (NMDA) receptor GluN2D subunit knockout (GluN2D-KO) mice. Intraperitoneal administration of ketamine or its enantiomers 10 min before the tail-suspension test exerted...
作者:Hideko Yamamoto , Etsuko Kamegaya , Yoko Hagino ...
来源:[J].Neuropharmacology(IF 4.114), 2017, Vol.112, pp.188-197Elsevier
摘要:... The GluN2D subunit of the NMDA receptor has low expression in the mature brain, and its role is not fully understood. In the present study, the effects of GluN2D subunit deficiency on emotional and cognitive function were investigated in GluN2D knockout (KO) mice. We found ...
作者:Patrick M. Callahan , Alvin V. Terry , Frederick R. Nelson ...
来源:[J].Neuropharmacology(IF 4.114), 2020Elsevier
摘要:NMDA receptors containing GluN2D subunits are expressed in the subthalamic nucleus and external globus pallidus, key nuclei of the indirect and hyperdirect pathways of the basal ganglia. This circuitry integrates cortical input with dopaminergic signaling to select advantageou...
作者:Manuela Mellone , Elisa Zianni , Jennifer Stanic ...
来源:[J].Neurobiology of Disease(IF 5.624), 2018Elsevier
摘要:... Spiny projection neurons (SPNs) are characterized by NMDARs expressing GluN2A and GluN2B subunits, while GluN2D is exclusively detected in striatal cholinergic interneurons (ChIs). In Parkinson's disease (PD), dopamine depletion and prolonged treatment with levodopa (L-DOPA) ...
作者:Gajanan P. Shelkar , Ratnamala Pavuluri , Pauravi J. Gandhi ...
来源:[J].Scientific Reports(IF 2.927), 2019, Vol.9 (1), pp.1-11DOAJ
摘要:Abstract The GluN2C- and GluN2D-containing NMDA receptors are distinct from GluN2A- and GluN2B-containing receptors in many aspects including lower sensitivity to Mg2+ block and lack of desensitization. Recent studies have highlighted the unique contribution of GluN2C and GluN2D ...
作者:Hassan A. Alsaad , Nicholas W. DeKorver , Zhihao Mao ...
来源:[J].Neurochemical Research(IF 2.125), 2019, Vol.44 (1), pp.61-77Springer
摘要:... While the actions of the predominate GluN2 NMDAR subunits, GluN2A and GluN2B are relatively well understood, the function of GluN2C and GluN2D subunits in the telencephalon is largely unknown. To better understand the possible role of GluN2C subunits, we used fluorescence in ...
作者:Dmitry A. Sibarov , Rashid Giniatullin , Sergei M. Antonov
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2018, Vol.506 (3), pp.648-652Elsevier
摘要:...(#br)In the current study, we explored the action of HCY on cerebellar neurons which natively express GluN2C and GluN2D subunits of NMDARs and compared this with the action of HCY on cortical neurons which are mainly composed by GluN2A and GluN2B subunits. To validate obtai...
作者:Vivek Gautam , Jonathan C. Trinidad , Ronald A. Rimerman ...
来源:[J].Neuropharmacology(IF 4.114), 2013, Vol.74, pp.96-107Elsevier
摘要:... In this study, we used a series of tagged, carboxy terminal constructs of GluN2D to identify associating proteins from rat brain. Of seven different GluN2D C-terminal fragments used as bait, only the construct containing amino acids 983–1097 associated with an E3 ubiqui...
作者:Toshifumi Yamamoto , Tomomi Nakayama , Junji Yamaguchi ...
来源:[J].Neuroscience Letters(IF 2.026), 2016, Vol.610, pp.48-53Elsevier
摘要:... Even three administrations of ketamine, daily or weekly, induced a rapid increase in locomotor activity in wild-type (WT), but not in GluN2D knockout (GluN2D-KO) mice. Furthermore, for WT mice receiving daily ketamine, elevated locomotor activity was maintained after a 1-...

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