全部文献期刊会议图书|学者科研项目
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作者:Xiaoqiang Wang , Yuan Chang , Yihua He ...
来源:[J].Neuropharmacology(IF 4.114), 2020, Vol.162
摘要:... Here, we tested whether glimepiride, another sulfonylurea with better safety, has comparable efficacy with glibenclamide and whether gene deletion of Trpm4 ( Trpm4 −/− ) exerts similar effect. Wild-type (WT) mice subjected to temporary middle cerebral artery occlusion (...
作者:Si Zhou , Pengxiao Zuo , Yuegang Zuo ...
来源:[J].Saudi Pharmaceutical Journal(IF 0.954), 2017, Vol.25 (6), pp.852-856
摘要:Abstract(#br)Glimepiride is one of the most widely prescribed antidiabetic drugs and contains both hydrophobic and hydrophilic functional groups in its molecules, and thus could be analyzed by either reversed-phase high performance liquid chromatography (HPLC) or hydrophilic int...
作者:Tianxing Dai , Caiyu Zhang , Ying Geng ...
来源:[J].Talanta(IF 3.498), 2018, Vol.187, pp.172-178
摘要:Abstract(#br)A simple and rapid identification method of glimepiride and its cis -isomer was established for the first time. The collision-induced dissociation (CID) mass spectrometry method was used in this study. Under negative ion mode, the CID mass spectra of the deprotonated...
作者:Nino G. Joy , Donna B. Tate , Stephen N. Davis
来源:[J].Metabolism(IF 3.096), 2015, Vol.64 (6), pp.729-737
摘要:Abstract(#br)Objective(#br)Reported rates of hypoglycemia in patients with type 2 diabetes mellitus are lower with glimepiride as compared to glyburide. The aim of this study was to determine whether physiologic differences in counterregulatory neuroendocrine and metabolic me...
作者:Haiying Li , Lilan Ma , Xiaxia Li ...
来源:[J].European Journal of Pharmaceutical Sciences(IF 2.987), 2015, Vol.77, pp.154-160
摘要:Abstract(#br)The purpose of this study was to improve the solubility and bioavailability of glimepiride (GLMP) by utilizing hydrotropy technique. Meglumine (MU) as a hydrotrope could form the stable complex with glimepiride. The optimal glimepiride and meglumine (GLMP–MU) ...
作者:Bo-Hyung Kim , Kwang-Hee Shin , JaeWoo Kim ...
来源:[J].Clinical Therapeutics(IF 2.23), 2009, Vol.31 (11), pp.2755-2764
摘要:Abstract(#br)Background: Coadministration of glimepiride and metformin has been used to achieve glucose control. Because compliance with a multiple medication regimen can be difficult for some patients, combination tablets of glimepiride + metformin might be a suitable alterna...
作者:Asmaa A. El-Zaher , Ehab F. Elkady , Hanan M. Elwy ...
来源:[J].Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy(IF 1.977), 2017, Vol.182, pp.175-182
摘要:Abstract(#br)In the present work, pioglitazone and glimepiride, 2 widely used antidiabetics, were simultaneously determined by a chemometric-assisted UV-spectrophotometric method which was applied to a binary synthetic mixture and a pharmaceutical preparation containing both d...
作者:Craig Osborne , Ewan West , William Nolan ...
来源:[J].Neuropharmacology(IF 4.114), 2016, Vol.101, pp.225-236
摘要:... Glimepiride, a sulphonylurea used for the treatment of diabetes, protected neurons against synapse damage induced by Aβ. The protective effects of glimepiride were multi-faceted. Glimepiride treatment was associated with altered synaptic membranes including the loss of ...
作者:Kouichi Inukai , Masaki Watanabe , Youhei Nakashima ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2004, Vol.328 (2), pp.484-490
摘要:Abstract(#br)Glimepiride, a third-generation sulfonylurea (SU), exerts its effects mainly by stimulating insulin secretion but has also been shown to have pleiotropic effects. Recent clinical studies showed glimepiride to enhance insulin sensitivity. In the present study, to cl...
作者:Günter Müller , Yusuke Satoh , Karl Geisen
来源:[J].Diabetes Research and Clinical Practice(IF 2.741), 1995, Vol.28, pp.S115-S137
摘要:Abstract(#br)The contribution of extrapancreatic effects of sulfonylureas to the blood glucose-decreasing activity was re-evaluated in vivo and in vitro with several conventional sulfonylureas and with the new one glimepiride. In vivo, in dogs, after single approximately equ...

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