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作者:Catherine C .Robertson , Stephen S Rich
来源:[J].Current Opinion in Genetics & Development(IF 7.47), 2018, Vol.50, pp.7-16
摘要:Type 1 diabetes is the most common autoimmune disorder in childhood, characterized by the development of autoimmunity through unknown environmental insults in genetically susceptible individuals. There are now over 50 regions of the genome that harbor type 1 diabetes susceptibili...
作者:Mireia Ramos-Rodríguez , Helena Raurell-Vila , Maikel L. Colli ...
来源:[J].Nature Genetics(IF 35.209), 2019, Vol.51 (11), pp.1588-1595
摘要:Abstract(#br)The early stages of type 1 diabetes (T1D) are characterized by local autoimmune inflammation and progressive loss of insulin-producing pancreatic β cells. Here we show that exposure to proinflammatory cytokines reveals a marked plasticity of the β-cell regulatory ...
作者:Suna Onengut-Gumuscu , Patrick Concannon
来源:[J].Journal of Autoimmunity(IF 8.145), 2005, Vol.25, pp.34-39
摘要:Abstract(#br)It has been more than 30 years since the first evidence was published suggesting the involvement of a specific chromosomal region, HLA, in modulating the risk for type 1 diabetes (T1D). In the intervening years, what have we learned regarding the identities of specif...
作者:Simon H.S. Pearce , Tony R. Merriman
来源:[J].Endocrinology and Metabolism Clinics of North America(IF 3.792), 2009, Vol.38 (2), pp.289-301
摘要:The search for the susceptibility alleles for the complex genetic conditions of type 1 diabetes and autoimmune thyroid diseases has gained momentum in recent years. Studies have revealed several novel disease susceptibility alleles of relevance to both conditions, which brings th...
作者:Houria Ounissi-Benkalha , Constantin Polychronakos
来源:[J].Trends in Molecular Medicine(IF 9.571), 2008, Vol.14 (6), pp.268-275
摘要:Susceptibility to type 1 diabetes (T1D) is determined by complex interactions between several genetic loci and environmental factors. Alleles at the human leukocyte antigen ( HLA) locus explain up to 50% of the familial clustering of T1D, and the remainder is contributed to by mu...
作者:Hiroshi Ikegami , Yumiko Kawabata , Shinsuke Noso ...
来源:[J].Diabetes Research and Clinical Practice(IF 2.741), 2007, Vol.77 (3), pp.S116-S121
摘要:Abstract(#br)Among candidate genes for type 1 diabetes, HLA , INS , CTLA4 , PTPN22 and SUMO4 have been shown to be associated with the disease in Caucasian populations. To clarify the similarities and differences in the contribution of these genes to type 1 diabetes between Asian...
作者:M.Ann Kelly , Catherine H. Mijovic , Anthony H. Barnett
来源:[J].Best Practice & Research Clinical Endocrinology & Metabolism(IF 4.912), 2001, Vol.15 (3), pp.279-291
摘要:Abstract(#br)Type 1 diabetes mellitus is a T-cell-mediated autoimmune disease characterized by the selective destruction of pancreatic beta cells. Susceptibility to the disease is determined by a combination of genetic and environmental factors. The genetic factors are ter...
作者:V. V. Nosikov , Yu. A. Seregin
来源:[J].Molecular Biology(IF 0.637), 2008, Vol.42 (5), pp.773-783
摘要:Abstract(#br)Type 1 diabetes mellitus (T1DM) is a widespread severe disease that results from autoimmune destruction of β cells in Langerhans islets of the pancreas. To date, several loci involved in T1DM have been reliably identified using various approaches: the MHC locus, V...

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