全部文献期刊会议图书|学者科研项目
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作者:Jordi Martorell-Marugan , Daniel Toro-Dominguez , Marta E. Alarcon-Riquelme ...
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)
摘要:Genetic association studies (GAS) aims to evaluate the association between genetic variants and phenotypes. In the last few years, the number of this type of study has increased exponentially, but the results are not always reproducible due to experimental designs, low sample siz...
作者:So Young Yang , Soon Ae Kim , Gang Min Hur ...
来源:[J].Molecular Autism, 2017, Vol.8 (1)
摘要:... Genetic polymorphisms in the AVPR1A promoter region have been identified to be associated with susceptibility to social deficits in autism spectrum disorder (ASD). We hypothesize that alleles of polymorphisms in the promoter region of AVPR1A may differentially interact with c...
作者:Darko Nedovic
来源:[J].Journal of Epidemiology(IF 2.113), 2016, Vol.26 (8), pp.399-404
摘要:The STrengthening the REporting of Genetic Association studies (STREGA) statement was based on the STrengthening the REporting of OBservational studies in Epidemiology (STROBE) statement, and it was published in 2009 in order to improve the reporting of genetic association (GA) studies...
作者:Yuan Li , Yuhai Zhao , Guoren Wang ...
来源:[J].Frontiers of Computer Science(IF 0.298), 2017, Vol.11 (3), pp.541-554
摘要:Interaction detection in large-scale genetic association studies has attracted intensive research interest, since many diseases have complex traits. Various approaches have been developed for finding significant genetic interactions. In this article, we propose a novel framework ...
作者:Zahra N. Sohani , David Meyre , Russell J. de Souza ...
来源:[J].BMC Genetics(IF 2.808), 2015, Vol.16 (1)
摘要:Abstract(#br) Background(#br)Advances in genomics technology have led to a dramatic increase in the number of published genetic association studies. Systematic reviews and meta-analyses are a common method of synthesizing findings and providing reliable estimates of the effect...
作者:Davnah Urbach , Mathieu Lupien , Margaret R. Karagas ...
来源:[J].Trends in Genetics(IF 9.772), 2012, Vol.28 (11), pp.538-543
摘要:Genetic association studies have become standard approaches to characterize the genetic and epigenetic variability associated with cancer development, including predispositions and mutations. However, the bewildering genetic and phenotypic heterogeneity inherent in cancer both ma...
作者:Olena Ohlei , Valerija Dobricic , Katja Lohmann ...
来源:[J].Parkinsonism and Related Disorders(IF 3.274), 2018
摘要:... For the latter, numerous genetic associations studies have been performed with largely inconsistent results. The aim of this study was to perform a field synopsis including systematic meta-analyses of genetic association studies in isolated dystonia.(#br)Methods(#br)For the f...
作者:Paul L. Auer , Nathan O. Stitziel
来源:[J].Trends in Cardiovascular Medicine(IF 1.466), 2017, Vol.27 (6), pp.397-404
摘要:Abstract(#br)Genetic association studies have a long history of delivering insightful results for cardiovascular disease (CVD) research. Beginning with early candidate gene studies, to genome-wide association studies, and now on to newer whole-genome sequencing studies, research ...
作者:Nicole C Allen , Sachin Bagade , Matthew B McQueen ...
来源:[J].Nature Genetics(IF 35.209), 2008, Vol.40 (7), pp.827-834
摘要:Lars Bertram and colleagues report the creation of an online database, SzGene, containing all published genetic association studies for schizophrenia. A series of meta-analyses reveals 24 variants in 16 genes to be associated with the disease with nominal significance, and fo...
作者:V.M. Lourenço , A.M. Pires
来源:[J].Computational Statistics and Data Analysis(IF 1.304), 2014, Vol.78, pp.33-42
摘要:... The methodology focuses on genetic association studies of quantitative traits, though it has much broader applications. The method is also compared to a benchmark rule from the literature and its good performance is validated by a simulation study and a real data example from...

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