全部文献期刊会议图书|学者科研项目
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作者:Jing Zhang , Jian Sun , Zhiwen Zhang ...
来源:[J].Human Pathology(IF 2.843), 2018, Vol.72, pp.59-65
摘要:... In this study, we aimed to analyze c-MET protein overexpression and gene amplification in MPPAC samples and to elucidate their relationship with the clinicopathological characteristics of the patients. c-MET protein expression was examined by immunohistochemical analyses, and...
作者:T. Kakuya , T. Mori , S. Yoshimoto ...
来源:[J].International Journal of Oral & Maxillofacial Surgery(IF 1.521), 2017, Vol.46 (8), pp.968-976
摘要:... Gene amplification of ACTN4 (protein name: actinin-4) is closely associated with the metastatic potential of various cancers. This retrospective study was performed to demonstrate the potential usefulness of ACTN4 gene amplification as a prognostic biomarker in patients w...
作者:Chiara Mondello , Valentina Guasconi , Elena Giulotto ...
来源:[J].DNA Repair(IF 4.274), 2002, Vol.1 (6), pp.483-493
摘要:Abstract(#br)To investigate the role of DNA double strand breaks (DSBs) and of their repair in gene amplification, we analyzed this process in the V3 Chinese hamster cell line and in the parental line AA8, after exposure to γ-rays and to hydrogen peroxide (H 2 O 2 ). V3 is defe...
作者:G. Meinhardt , S. Kaltenberger , C. Fiala ...
来源:[J].Placenta(IF 3.117), 2015, Vol.36 (8), pp.803-808
摘要:... However, no data are available to address whether trophoblast-related ERBB2 expression might also be linked to genomic amplification.(#br)Methods(#br)Dual color silver as well as fluorescence in situ hybridization analyses were carried out to evaluate frequency and degree of ...
作者:Bin Yan , Ruoyun Ouyang , Chenghui Huang ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2012, Vol.427 (3), pp.473-477
摘要:... We studied whether hyperthermia can induce gene amplification in cancer cells and explored potential underlying molecular mechanisms.(#br)Materials and methods(#br)(1) Hyperthermia: HCT116 colon cancer cells received water-submerged heating treatment at 42 or 44 °C for 3...
作者:Hyun Chang , Yaewon Yang , Jong-Seok Lee ...
来源:[J].Clinical Lung Cancer(IF 2.038), 2018
摘要:Abstract(#br)Purpose(#br)The aim of the present study was to examine the prognostic role of amplification and increased expression of the epidermal growth factor receptor ( EGFR ) gene in surgically resected non-adenocarcinoma of non-small cell lung cancer (NA-NSCLC).(#br)Materi...
作者:Andrew B Reams , Ellen L Neidle
来源:[J].Journal of Molecular Biology(IF 3.905), 2004, Vol.338 (4), pp.643-656
摘要:Abstract(#br)A system for studying gene amplification in the bacterium Acinetobacter sp. strain ADP1 was used to isolate 105 spontaneous mutants. The method selects for the elevated expression of neighboring transcriptional units in a parent strain lacking its normal transcript...
作者:Yukiko Ono , Yukihiro Nakanishi , Masahiro Gotoh ...
来源:[J].Cancer Letters(IF 4.258), 2002, Vol.175 (2), pp.197-204
摘要:Abstract(#br)Both epidermal growth factor receptor (EGFR) gene amplification and laminin (Ln)-5 γ2 chain overexpression have been reported to be poor prognostic factors in patients with squamous cell carcinoma (SCC) of the head and neck. Here we report our investigation of th...
作者:Alberto Salzano , Nino Kochiashvili , Solomon G. Nergadze ...
来源:[J].DNA Repair(IF 4.274), 2008, Vol.8 (1), pp.19-28
摘要:Abstract(#br)Gene amplification, a key mechanism for oncogene activation and drug resistance in tumour cells, involves the generation and joining of DNA double-strand breaks. Amplified DNA can be carried either on intra-chromosomal arrays or on extra-chromosomal elements (dou...
作者:Kiyomi Taniyama , Katsunari Ishida , Tamaki Toda ...
来源:[J].Breast Cancer(IF 1.33), 2008, Vol.15 (3), pp.231-240
摘要:... The detection of HER2 gene amplification using fluorescence in situ hybridization (FISH) provides superior prognostic information for the diagnosis of breast cancer. However, the relationship between pHER2 expression in tissue samples and HER2 gene amplification remains u...

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