全部文献期刊会议图书|学者科研项目
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作者:Qingguo Li , Wenhai Huang , Juan Yang ...
来源:[J].European Journal of Pharmaceutical Sciences(IF 2.987), 2018, Vol.119, pp.62-69Elsevier
摘要:Abstract(#br)Absorption mechanism of edaravone (EDR) was studied to inform the preparation of gastric retention pellets with the aim to enhance its oral bioavailability. Three different models, namely, Caco-2 cells model, in situ single-pass intestinal perfusion model, and ev...
作者:Anita K. Lalloo , Emma L. McConnell , Lan Jin ...
来源:[J].International Journal of Pharmaceutics(IF 3.458), 2012, Vol.431 (1-2), pp.90-100Elsevier
摘要:Abstract(#br)Gastric retention is postulated as an approach to improve bioavailability of compounds with narrow absorption windows. To elucidate the role of image size on gastric retention and pharmacokinetics, formulations with different image sizes and swelling kinetics but sim...
作者:Jun Chen , William E Blevins , Haesun Park ...
来源:[J].Journal of Controlled Release(IF 7.633), 2000, Vol.64 (1), pp.39-51Elsevier
摘要:... The gastric retention property of the prepared SPH composites was tested in dogs both in fasted and fed conditions. The SPH composites were placed in a hard gelatin capsule (size 000) for oral administration. All dogs tested were fasted for 36 h before experiments. Under...
作者:Iman S. Ahmed , James W. Ayres
来源:[J].International Journal of Pharmaceutics(IF 3.458), 2006, Vol.330 (1), pp.146-154Elsevier
摘要:Abstract(#br)A gastric retention formulation (GRF) made of naturally occurring carbohydrate polymers and containing riboflavin was tested in vitro for swelling and dissolution characteristics as well as in fasting dogs for gastric retention. The bioavailability of riboflavin, a d...
作者:Arati A Deshpande , Navnit H Shah , Christopher T Rhodes ...
来源:[J].International Journal of Pharmaceutics(IF 3.458), 1997, Vol.159 (2), pp.255-258Elsevier
摘要:Abstract(#br)A novel gastric retention system was developed consisting of a tablet coated with a porous membrane. The membrane consisted of aqueous dispersions of methyl methacrylate copolymers, plasticizers, anti tacking and anti foaming agents. This article presents research ...
作者:Arati A. Deshpande , Navnit H. Shah , Christopher T. Rhodes ...
来源:[J].Pharmaceutical Research(IF 4.742), 1997, Vol.14 (6), pp.815-819Springer
摘要:... We report on the development of a novel controlled-release gastric retention system, which consists of a matrix tablet, coated with a permeable membrane. When immersed in simulated gastric fluid, the tablet expands. The tablet remains expanded for eighteen to twenty hours,...
作者:Jeff Wang , Wei-Chiang Shen
来源:[J].International Journal of Pharmaceutics(IF 3.458), 2000, Vol.204 (1), pp.111-116Elsevier
摘要:... A prolonged retention of Pal-BBI was found in the stomach. Furthermore, a significant amount of Pal-BBI was detected as intact polypeptide in the stomach of mice fed with Pal-BBI, while only degradation products were detected with BBI. There was also a significant increa...

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