全部文献期刊会议图书|学者科研项目
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作者:Chiara Magri , Edoardo Giacopuzzi , Luca La Via ...
来源:[J].Scientific Reports(IF 2.927), 2018, Vol.8 (2), pp.1187-1192
摘要:... GAD1 encodes for GAD67 enzyme, catalyzing the production of gamma-aminobutyric acid (GABA) from L-glutamic acid. Here, we studied the impact of this mutation on GAD67 activity, dimerization and subcellular localization. Biochemical assay revealed that c.391 A >â...
作者:Benoit Souchet , Arnaud Duchon , Yuchen Gu ...
来源:[J].Scientific Reports(IF 2.927), 2019, Vol.9 (1), pp.278-283
摘要:... One potential target is DYRK1A, a multifunctional kinase encoded by chromosome 21 that, when overexpressed, alters neuronal excitation–inhibition balance and increases GAD67 interneuron density. We used a green tea extract enriched in EGCG to inhibit DYRK1A function only d...
作者:S A Heldt , L Mou , K J Ressler
来源:[J].Translational Psychiatry, 2012, Vol.2 (Pt 2), pp.e181-e181
摘要:... Most GABA synthesis in the brain is catalyzed in inhibitory neurons from L -glutamic acid by the enzyme glutamic acid decarboxylase 67 (GAD67). In the current study, we sought to examine the acquisition and extinction of conditioned fear in mice with knocked down express...
作者:Christine Manrique , Valérie Compan , Céline Rosselet ...
来源:[J].Journal of Biotechnology(IF 3.183), 2009, Vol.142 (3), pp.185-192
摘要:... In the present study, we performed local intracerebral infusions of naked siRNA against glutamic acid decarboxylase 67 (GAD67) mRNA to engineer specific knock-down of GAD67 protein in the striatum of adult rats. Directly injecting a mix of GAD67 siRNAs into the striatum decr...
作者:D D Dickerson , K A Overeem , A R Wolff ...
来源:[J].Translational Psychiatry, 2014, Vol.4 (7), pp.e418-e418
摘要:... Glutamic decarboxylase (GAD67) levels were separately assayed in these regions using western blot. GAD67 expression was also assessed within parvalbumin-positive cells in the dorsal and ventral hippocampus using immunofluorescence alongside stereological analysis of parvalbum...
作者:Bindu Jayakrishnan , David E Hoke , Christopher G Langendorf ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.6 (4)
摘要:BACKGROUND: Autoantibodies to GAD65 (anti-GAD65) are present in the sera of 70-80% of patients with type 1 diabetes (T1D), but antibodies to the structurally similar 67 kDa isoform GAD67 are rare. Antibodies to GAD67 may represent a cross-reactive population of anti-GAD65, but th...
作者:K. Janitzky , A. Peine , A. Kröber ...
来源:[J].Behavioural Brain Research(IF 3.327), 2014, Vol.272, pp.141-149
摘要:... Hence, to investigate sexual dimorphism of stress-induced neuronal changes, we studied effects of acute TMT exposure on CRF mRNA expression in stress-related brain regions in male and female GAD67 mice and their wild-type littermates. In GAD67 mice, heterozygous knock-in of G...
作者:T. Kakizaki , N. Oriuchi , Y. Yanagawa
来源:[J].Neuroscience(IF 3.122), 2015, Vol.288, pp.86-93
摘要:... Glutamate decarboxylase (GAD) is a GABA-synthesizing enzyme and two isoforms of GAD, GAD65 and GAD67 are encoded by two independent genes. There was virtually no GABA content in GAD65/GAD67 double knockout (GADs DKO) mouse brains. Neither GABAergic nor glycinergic inhibitor...
作者:Yun Lu , Changjun Li , Mei Zhou ...
来源:[J].Pharmacology, Biochemistry and Behavior(IF 2.608), 2015, Vol.132, pp.96-102
摘要:... Our results showed that the cognitive function was partially impaired, and the expression of neuronal nuclei (NeuN), glutamic acid decarboxylase 67 (GAD67) and γ-aminobutyric acid-B receptor 1 (GABA B R1) in hippocampal CA1 area was attenuated after 2VO, which were not obse...

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