全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Manjusha M. Kulkarni , Annette N. Ratcliff , Menakshi Bhat ...
来源:[J].Retrovirology(IF 5.657), 2017, Vol.14 (1)Springer
摘要:Like all viruses, HIV-1 relies on host systems to replicate. The human purinome consists of approximately two thousand proteins that bind and use purines such as ATP, NADH, and NADPH. By virtue of their purine binding pockets, purinome proteins are highly druggable, and many exis...
作者:Yazan Alwarawrah , Philip Hughes , David Loiselle ...
来源:[J].Cell Chemical Biology, 2016, Vol.23 (6), pp.678-688Elsevier
摘要:... Herein we identify Fasnall, a thiophenopyrimidine selectively targeting FASN through its co-factor binding sites. Global lipidomics studies with Fasnall showed profound changes in cellular lipid profiles, sharply increasing ceramides, diacylglycerols, and unsaturated fatty ac...
作者:Alwarawrah Yazan , Hughes Philip , Loiselle David ...
来源:[J].Cell chemical biology, 2016, Vol.23 (6), pp.678-88PubMed
摘要:... Herein we identify Fasnall, a thiophenopyrimidine selectively targeting FASN through its co-factor binding sites. Global lipidomics studies with Fasnall showed profound changes in cellular lipid profiles, sharply increasing ceramides, diacylglycerols, and unsaturated fatty ac...
作者:Haystead T A J
来源:[J].Methods in molecular biology (Clifton, N.J.), 2018, Vol.1709, pp.75-86PubMed
摘要:... We show several case history examples of the methodology that led to the discovery of the Fatty acid synthase inhibitor, FASNALL, the DAPK3 inhibitor HS38, and HS72, an allosteric inhibitor selective for Hsp70i.

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