全部文献期刊会议图书|学者科研项目
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作者:Mingxing Fang , Na Liu , Xiaoguang Yao ...
来源:[J].Scientific Reports(IF 2.927), 2020, Vol.10 (14), pp.345-350
摘要:... Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that is involved in cell growth and intracellular signal transduction pathways. This study explored the potential role of FAK in AECs during lung injury induced by mechanical ventilation. High-volume mechani...
作者:Yuhu He , Pu Zou , Yufei Lu ...
来源:[J].Journal of Molecular and Cellular Cardiology(IF 5.148), 2020, Vol.139, pp.1-13
摘要:... Moreover, we found that OPG, as a ligand for integrin αVβ3, mediated phosphorylation of focal adhesion kinase (FAK) and actin cytoskeleton reorganization, resulting in YAP dephosphorylation in hASMCs. OPG-dependent YAP and VSMC activation was prevented by treatment wit...
作者:Hao Xu , Yuan Yuan , Wenqian Wu ...
来源:[J].Journal of Biosciences(IF 1.759), 2017, Vol.42 (3), pp.491-499
摘要:... Our results showed that in cervical cancer cell lines HeLa/SiHa, Rac1 activation in hypoxia could stimulate invasion and migration, and this process was mediated by integrin αvβ3-mediated FAK and PI3K phosphorylation. Furthermore, hypoxia induced a dramatic increase in α...
作者:Shaogang Sun , Hsin-Jung Wu , Jun-Lin Guan
来源:[J].Scientific Reports(IF 2.927), 2018, Vol.8 (1), pp.48-50
摘要:Abstract(#br)Focal adhesion kinase (FAK) is essential in embryonic angiogenesis by regulating endothelial cell (EC) survival and barrier functions through its kinase-independent and –dependent activities. Here, we generated EC-specific tamoxifen-inducible FAK knockout and FAK...
作者:James M. Murphy , Kyuho Jeong , Yelitza A. R. Rodriguez ...
来源:[J].Scientific Reports(IF 2.927), 2019, Vol.9 (19), pp.1057-1069
摘要:... To evaluate which PTK is critical to promote the cytokine-induced inflammatory cell adhesion molecule (CAM) expression including VCAM-1, ICAM-1, and E-selectin in human aortic endothelial cells (HAoECs), we have tested pharmacological inhibitors of major PTKs: Src and the focal adhesion kinase (FAK...
作者:Kaifeng Guo , Pan Pan , Mian Wu ...
来源:[J].Molecular and Cellular Endocrinology(IF 4.039), 2020, Vol.505
摘要:... In vitro , hyperglycemia induced the upregulation of ANGPTL4, which led to activation of integrin-β1/FAK signaling with increased apoptosis of podocytes and actin cytoskeleton derangement. These pathological changes were reversed by transfection with a lentivirus expressing...
作者:Qinggang Wang , Shyam K. More , Emilie E. Vomhof-DeKrey ...
来源:[J].Scientific Reports(IF 2.927), 2019, Vol.9 (2), pp.704-707
摘要:... The non-receptor tyrosine kinase focal adhesion kinase (FAK) stimulates epithelial motility. A virtual screen identified the small drug-like FAK mimic ZINC40099027, which activates FAK. We assessed whether ZINC40099027 promotes FAK-Tyr-397 phosphorylation and wound heali...
作者:Vijay Kumar , Upendra Kumar Soni , Vineet Kumar Maurya ...
来源:[J].Scientific Reports(IF 2.927), 2017, Vol.7 (1), pp.2185-2188
摘要:... therefore, we have investigated the signaling of ITGB8 via FAK and VAV-RAC1 in the endometrial epithelial cells. Integrin beta8 was found elevated in epithelial cells at late-pre-receptive (day4, 1600 h) and receptive (day5, 0500 h) stages of endometrial receptiv...
作者:Qiaoqiao Wan , ThucNhi TruongVo , Hannah E. Steele ...
来源:[J].Scientific Reports(IF 2.927), 2017, Vol.7 (Pt 4), pp.673-687
摘要:Abstract(#br)Focal adhesion kinase (FAK) and Src family kinases (SFK) are known to play critical roles in mechanotransduction and other crucial cell functions. Recent reports indicate that they reside in different microdomains of the plasma membrane. However, little is known abou...
作者:B Xu , J Lefringhouse , Z Liu ...
来源:[J].Oncogenesis, 2017, Vol.6 (1), pp.e295-e295
摘要:Abstract(#br)Integrins, a family of heterodimeric receptors for extracellular matrix, are promising therapeutic targets for ovarian cancer, particularly high-grade serous-type (HGSOC), as they drive tumor cell attachment, migration, proliferation and survival by activating focal adhesion kinase (FAK...

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