全部文献期刊会议图书|学者科研项目
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作者:Mami Sato , Ryosuke Kusumi , Shinji Hamashima ...
来源:[J].Scientific Reports(IF 2.927), 2018, Vol.8 (1), pp.1-9DOAJ
摘要:... In this context, the small molecule erastin was reported to target and inhibit system xc−, leading to cysteine starvation, glutathione depletion and consequently ferroptotic cell death. Although the inhibitory effect of erastin towards system xc− is well-documented, ...
作者:Haizhong Huo , Zhiyuan Zhou , Jian Qin ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.11 (5)DOAJ
摘要:We here evaluated the potential anti-colorectal cancer activity by erastin, a voltage-dependent anion channel (VDAC)-binding compound. Our in vitro studies showed that erastin exerted potent cytotoxic effects against multiple human colorectal cancer cell lines, possibly via induc...
作者:Ryosuke Yoshioka , Yusuke Fujieda , Yamato Suzuki ...
来源:[J].Journal of Pharmacological Sciences(IF 2.15), 2019, Vol.140 (3), pp.242-247Elsevier
摘要:... At 7 h after PPG administration, the efficacy of erastin, a representative xCT inhibitor, was clearly shown. We synthesized a new compound, Compound A, which had much higher inhibitory effect on xCT than erastin both in vitro and in vivo .(#br)We established a mouse model of ...
作者:Ding Wang , Nan Xie , Wanli Gao ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2018Elsevier
摘要:... Here, we showed that the ferroptosis inducer erastin did not cause cell death in human PBMCs. In contrast, erastin-induced lipid peroxidation promoted human PBMC proliferation and differentiation into B cells and natural killer cells through inhibition of bone morphogenetic p...
作者:Chengcheng Gai , Mengyu Yu , Zihaoran Li ...
来源:[J].Journal of Cellular Physiology(IF 4.218), 2020, Vol.235 (4), pp.3329-3339Wiley
摘要:... However, some non‐small‐cell lung cancer (NSCLC) cell lines are less sensitive to erastin‐induced ferroptotic cell death. Elucidating the mechanism of resistance of cancer cells to erastin‐induced ferroptosis and increasing the sensitivity of cancer cells to erastin...
作者:David N. DeHart , Diana Fang , Kareem Heslop ...
来源:[J].Biochemical Pharmacology(IF 4.576), 2018, Vol.148, pp.155-162Elsevier
摘要:... High free tubulin in cancer cells closes voltage dependent anion channels (VDAC) to decrease mitochondrial membrane potential (ΔΨ), an effect antagonized by erastin, the canonical promotor of ferroptosis. Previously, we identified six compounds (X1–X6) that also block ...
作者:Silvia Codenotti , Maura Poli , Michela Asperti ...
来源:[J].Journal of Cancer Research and Clinical Oncology(IF 2.914), 2018, Vol.144 (9), pp.1717-1730Springer
摘要:... Here we investigated the effects of ferroptosis inducers called erastin and RSL3, which act by glutathione depletion and GPx4 inactivation, respectively, on muscle-derived cell lines of embryonal and alveolar rhabdomyosarcoma (RMS), and mouse normal skeletal C2C12 myoblasts.(...
作者:Yan Chen , Guoqing Zhu , Ya Liu ...
来源:[J].Cellular Signalling(IF 4.304), 2019, Vol.63Elsevier
摘要:... Here, we observed that erastin suppressed the malignant phenotypes of liver cancer cells by inhibiting O-GlcNAcylation of c-Jun and further inhibited protein expression, transcription activity and nuclear accumulation of c-Jun. Overexpression of c-Jun-WT with simultaneous PuG...
作者:Hyunjin Kim , Jin Hyup Lee , Jeen-Woo Park
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2020Elsevier
摘要:... This pathway is being considered as an alternative anticancer therapeutic strategy, and the chemoreagent erastin induces ferroptosis by blocking system Xc − , which causes a cysteine shortage that depletes intracellular GSH. Mitochondrial NADP + -dependent isocitrate dehy...
作者:Ryosuke Shintoku , Yuta Takigawa , Keiichi Yamada ...
来源:[J].Cancer Science(IF 3.479), 2017, Vol.108 (11), pp.2187-2194Wiley
摘要:In cancer cells the small compounds erastin and RSL 3 promote a novel type of cell death called ferroptosis, which requires iron‐dependent accumulation of lipid reactive oxygen species. Here we assessed the contribution of lipid peroxidation activity of lipoxygenases ( LOX...

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