全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Ning Wang , Yanhua Fan , Chun-Mao Yuan ...
来源:[J].BMC Cancer(IF 3.333), 2019, Vol.19 (1), pp.1-9DOAJ
摘要:... With the exception of a recently identified agent, EQW, most of these inhibitors target upstream factors but not ERK1/2; no activator of ERK1/2 is currently available. Method A library of compounds isolated from medicinal plants of China was screened for anti-cancer acti...
作者:Min Cheol Joo , Chul Hwan Jang , Jong Tae Park ...
来源:[J].Neural Regeneration Research(IF 0.144), 2018, Vol.13 (2), pp.340-346DOAJ
摘要:... Western blot analysis was performed to measure p38-RhoA and ERK1/2-Bcl-2 pathways related protein levels in the injured spinal cord. Rat sensory and motor functions were similar between SCI and ES groups. Compared with the SCI group, in the ES group, the latencies of the soma...
作者:Luca Forte , Federica Turdo , Cristina Ghirelli ...
来源:[J].BMC Cancer(IF 3.333), 2018, Vol.18 (1), pp.1-11DOAJ
摘要:... Methods The expression of CDCP1, PDGFRβ and ERK1/2cell was tested by Western blot after stimulation of MDA-MB-231 cells with PDGF-BB and, similarly, in presence or not of ERK1/2 inhibitor in a panel of TNBC cell lines. Knock-down of PDGFRβ was established in MDA-MB-231 ...
作者:Dimitrios Toumpanakis , Vyronia Vassilakopoulou , Ioanna Sigala ...
来源:[J].Respiratory Research(IF 3.642), 2017, Vol.18 (1)Springer
摘要:... ERK1/2 kinase is a downstream target of Src. We hypothesized that Src is activated in the lung during IRB, mediates ERK1/2 activation and IRB-induced lung injury.
作者:Phaijit Sritananuwat , Natthaporn Sueangoen , Parichut Thummarati ...
来源:[J].Cancer Cell International(IF 2.093), 2017, Vol.17 (1)Springer
摘要:... Here we investigated the roles of non-Smad pathway (ERK1/2) and Smad in TGF-β tumor promoting and suppressing activities in intrahepatic cholangiocarcinoma (ICC) cells.
作者:Jennifer Munkley , Nicholas P Lafferty , Gabriela Kalna ...
来源:[J].BMC Cancer(IF 3.333), 2015, Vol.15 (1)Springer
摘要:... Advanced PCa often has hyper-activated RAS/ERK1/2 signalling thought to be due to loss of function of key negative regulators of the pathway, the details of which are not fully understood.(#br) Methods(#br)We recently carried out a genome-wide study and identified a subset of...
作者:Jaroslav Kalous , Anna Tetkova , Michal Kubelka ...
来源:[J].International Journal of Molecular Sciences(IF 2.464), 2018, Vol.19 (3)DOAJ
摘要:Although the involvement of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) pathway in the regulation of cytostatic factor (CSF) activity; as well as in microtubules organization during meiotic maturation of oocytes; has already been described in detail; rather less a...
作者:Zilong Yan , Kenoki Ohuchida , Shuang Fei ...
来源:[J].Journal of Experimental & Clinical Cancer Research(IF 3.066), 2019, Vol.38 (1), pp.1-16DOAJ
摘要:... ERK1/2 inhibitor can suppress growth of KRAS-mutant pancreatic tumors by targeting cancer cell. However, no studies have shown the expression of ERK1/2 on pancreatic stromal and its effect on pancreatic cancer–stromal interaction. Methods Immunohistochemistry and weste...
作者:Zeyou Wang , Qin Guo , Rong Wang ...
来源:[J].Journal of Hematology & Oncology(IF 4.458), 2016, Vol.9 (1), pp.1-13DOAJ
摘要:Abstract Background As a well-characterized key player in various signal transduction networks, extracellular-signal-regulated kinase (ERK1/2) has been widely implicated in the development of many malignancies. We previously found that Leucine-rich repeat containing 4 (LRRC4) was...
作者:Xuelian Li , GuoYuan Wang , MuGe QiLi ...
来源:[J].Cellular Physiology and Biochemistry(IF 3.415), 2018, Vol.45 (5), pp.1955-1965DOAJ
摘要:... The enhanced phosphorylation of Erk1/2 caused by TAC (p-Erk1, 1.49±0.19-fold; p-Erk2, 1.96±0.68-fold) was suppressed by aspirin (p-Erk1, 1.04±0.15-fold; p-Erk2, 0.87±0.06-fold). SerpinE2 levels were suppressed via the Erk1/2 signalling pathway following treatment wit...

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