全部文献期刊会议图书|学者科研项目
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作者:Guangjian Yang , Jun Li , Haiyan Xu ...
来源:[J].Lung Cancer(IF 3.392), 2020
摘要:Abstract(#br)Objectives(#br)To describe the treatment patterns and outcomes of Chinese non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor ( EGFR ) exon 20 insertion (ex20 in.) mutations in real-world as EGFR ex20 in. consist of a diverse group of mu...
作者:Kaiyan Chen , Guoping Cheng , Fanrong Zhang ...
来源:[J].Lung Cancer(IF 3.392), 2020, Vol.142, pp.98-105
摘要:Abstract(#br)Objectives(#br)The efficacy of immunotherapy in epidermal growth factor receptor (EGFR) -activating non-small cell lung cancer (NSCLC) is limited. However, a series of patients with uncommon EGFR alterations was reported to derive clinical benefit from PD-1 blockad...
作者:Heba Abdelrasheed Allam , Enayat E. Aly , Ahmed K.B.A.W. Farouk ...
来源:[J].Bioorganic Chemistry(IF 1.732), 2020, Vol.98
摘要:... The target compounds were screened for their efficacy as EGFR inhibitors compared to gefitinib. Compounds eliciting superior EGFR inhibitory activity were further screened for their in vitro cytotoxicity against two human cancer cell lines namely: MCF7 (breast) and A549 (lu...
作者:Hui Hu , Xiao-Kang Miao , Jing-Yi Li ...
来源:[J].European Journal of Pharmacology(IF 2.592), 2020, Vol.874
摘要:Abstract(#br)The tyrosine kinase inhibitor (TKI) gefitinib exerts good therapeutic effect on NSCLC patients with sensitive EGFR-activating mutations. However, most patients ultimately relapse due to the development of drug resistance after 6–12 months of treatment. Here, we sh...
作者:Nosha Farhadfar , Hemant Murthy , Tao Wang ...
来源:[J].Biology of Blood and Marrow Transplantation(IF 3.94), 2020, Vol.26 (3), pp.S134-S135
摘要:... The aim of this study is to examine whether utilization of incremental degrees of renal dysfunction based on eGFR improves the utility of HCT-CI to predict allogeneic HCT outcomes.(#br)Method(#br)Patients age ≥40 years receiving HCT for malignancies from 2008 to 2016 were ...
作者:Iosune Baraibar , Laura Mezquita , Ignacio Gil-Bazo ...
来源:[J].Critical Reviews in Oncology / Hematology(IF 4.637), 2020, Vol.148
摘要:Abstract(#br)Approximately 4% of epidermal growth factor receptor (EGFR)−mutated non-small cell lung cancer (NSCLC) present EGFR exon 20 in-frame insertions, accounting for 0.3 %–3.7 % of NSCLC. In addition, 2 %–4 % of patients with NSCLC harbor human epidermal growth fact...
作者:Liang Liu , Shuai Song , Ya Ping Zhang ...
来源:[J].Experimental Cell Research(IF 3.557), 2020
摘要:... In addition, EGFR and downstream gene expression was significantly enhanced. In vivo, EndMT was significantly inhibited after lentivirus-AR-shRNA was delivered to the myocardium post MI. In addition, silencing AR ameliorated cardiac function by decreasing the extent of CF. Fu...
作者:Wenmiao Li , Cuijing Xu , Cui Hao ...
来源:[J].Antiviral Research(IF 3.925), 2020, Vol.177
摘要:... Myricetin also down-regulate the cellular EGFR/PI3K/Akt signaling pathway to further inhibit HSV infection and its subsequent replication. Most importantly, intraperitoneal therapy of myricetin markedly improved mice survival and reduced virus titers in both lungs and spinal ...
作者:Sofía del Carmen , Luís Antonio Corchete , Ruth Gervas ...
来源:[J].Scientific Reports(IF 2.927), 2020, Vol.10 (11), pp.533-43
摘要:... We evaluated EGFR copy number (using SNP arrays and FISH) and its expression and regulation (by mRNA and miRNA arrays). We found differences between metastatic and non-metastatic sCRCs for MLH1 ( p = 0.05), PMS2 ( p = 0.02), CEA ( p < 0.001) and EGFR ( p < 0.001) expression. ...
作者:Evan K. Day , Nisha G. Sosale , Aizhen Xiao ...
来源:[J].Cell Reports, 2020, Vol.30 (10), pp.3383-3396.e7
摘要:... Here, we identify a SPRY2-dependent bypass signaling mechanism in glioblastoma that drives resistance to EGFR and MET inhibition. In glioblastoma cells treated with EGFR and MET inhibitors, SPRY2 expression is initially suppressed but eventually rebounds due to NF-κB pathwa...

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