全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
中外文文献  中文文献  外文文献
作者:Lei Huang , Zhaoxin Wang , Yuhong Yao ...
来源:[J].BMC Medical Education(IF 1.409), 2015, Vol.15 (1)Springer
摘要:... However, the relationship between parental rearing styles and medical students’ critical thinking disposition has rarely been considered. The aim of this study was to investigate whether parental rearing styles were significant predictors of critical thinking disposition...
作者:Katsuhiro Kanda , Ryosuke Takahashi , Takashi Yoshikado ...
来源:[J].Drug Metabolism and Pharmacokinetics(IF 2.071), 2018, Vol.33 (3), pp.164-172Elsevier
摘要:Abstract(#br)This study describes the total disposition profiling of rosuvastatin (RSV) and pitavastatin (PTV) using a single systematic procedure called D-PREX (Disposition Profile Exploration) in sandwich-cultured human hepatocytes (SCHH). The biliary excretion fractions of bot...
作者:Bhar M , Khargharia S , Chakraborty A ...
来源:[J].Indian Journal of Pharmacology(IF 0.583), 2009, Vol.41 (3), pp.106DOAJ
摘要:Objective: To study the variation of disposition kinetic values of sparfloxacin in healthy, hepatopathic, and nephropathic chickens after a single intravenous administration. Materials and Methods: Hepatotoxicity was induced by the administration of paracetamol (500 mg / kg / d...
作者:Ryosuke Takahashi , Hisashi Ichikawa , Katsuhiro Kanda
来源:[J].Drug Metabolism and Pharmacokinetics(IF 2.071), 2016, Vol.31 (2), pp.167-171Elsevier
摘要:Abstract(#br)Better prediction of drug disposition prior to the clinical trial is critical for the efficient development of new drugs. The purpose of this study is to develop a novel multiple assessment methodology of hepatocellular drug disposition from drug uptake to efflux in...
作者:Norikazu Matsunaga , Kaori Suzuki , Takeo Nakanishi ...
来源:[J].Drug Metabolism and Pharmacokinetics(IF 2.071), 2015, Vol.30 (2), pp.142-148Elsevier
摘要:... This study aimed to evaluate the interaction of CsA with hepatic disposition of MPA and MPAG in sandwich-cultured human hepatocytes (SCHH) by a mathematical modeling approach. In addition, the inhibition of CsA for glucuronidation of MPA to MPAG was examined in human liver mi...
作者:Johan Gabrielsson , Lambertus A. Peletier
来源:[J].The AAPS Journal(IF 4.386), 2017, Vol.19 (3), pp.772-786Springer
摘要:In this paper, we derive explicit expressions for the concentrations of ligand L , target R and ligand-target complex RL at steady state for the classical model describing target-mediated drug disposition, in the presence of a constant-rate infusion of ligand. We demonstrate that...
作者:Akira Takagi , Yoshiyuki Yabe , Yoshikazu Oka ...
来源:[J].Drug Metabolism and Pharmacokinetics(IF 2.071), 2002, Vol.17 (2), pp.136-141Elsevier
摘要:Summary:(#br)The effects of co-administration of cationic proteins on the in vivo disposition characteristics of recombinant human interleukin-11 (rhIL-11) in mice and on the renal disposition in the perfused rat kidney were investigated. Following a bolus intravenous injectio...
作者:Inna Y. Gong , Richard B. Kim
来源:[J].Drug Metabolism and Pharmacokinetics(IF 2.071), 2013, Vol.28 (1), pp.4-18Elsevier
摘要:... Among drug transporters, the organic anion transporting polypeptide (OATP) class of transporters have proven to be remarkably important to the cellular uptake disposition of a variety of clinically important drugs, particularly in organs such as the intestine and liver; we no...
作者:Yoshinori Sugiura
来源:[J].PLoS ONE(IF 3.73), 2018, Vol.8 (11)DOAJ
摘要:This study investigated the relationship between disposition (people's consistent motivation) toward critical thinking (CT) and worrying. In spite of its connection to psychopathology, worry is thought to represent an effort at problem-solving. Moreover, worry has been found to b...
作者:Mohamed A. Kamal , Richard F. Keep , David E. Smith
来源:[J].Drug Metabolism and Pharmacokinetics(IF 2.071), 2008, Vol.23 (4), pp.236-242Elsevier
摘要:Summary:(#br)Pept2 knockout mice are an important tool to evaluate the evolving role and relevance of this proton-coupled oligopeptide transporter beyond drug disposition, where the transporter also modulates the pharmacodynamic and toxicodynamic effects of drug substrates. ...

我们正在为您处理中,这可能需要一些时间,请稍等。

资源合作:cnki.scholar@cnki.net, +86-10-82896619   意见反馈:scholar@cnki.net

×