全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Pengwei Zhang , Jian Xie , Guanghui Yi ...
来源:[J].Virus Research(IF 2.745), 2005, Vol.112 (1), pp.9-23Elsevier
摘要:Abstract(#br)Classical swine fever virus (CSFV) non-structural protein 5B (NS5B) encodes an RNA-dependent RNA polymerase (RdRp), a key enzyme which initiates RNA replication by a de novo mechanism without a primer and is a potential target for anti-virus therapy. We expressed...
作者:Charles Pellerin , Sylvain Lefebvre , Michael J Little ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2002, Vol.295 (3), pp.682-688Elsevier
摘要:Abstract(#br)A variety of 3 ′ -untranslated regions (UTRs) were cloned from infectious hepatitis C virus human samples and examined in NS5B polymerase de novo initiation reactions. We isolated and characterized four distinct 3 ′ -UTRs that harbor the conserved terminal 98 ...
作者:Sarah L. Noton , Waleed Aljabr , Julian A. Hiscox ...
来源:[J].Virology(IF 3.367), 2014, Vol.462-463, pp.318-327Elsevier
摘要:Abstract(#br)Respiratory syncytial virus RNA dependent RNA polymerase (RdRp) initiates RNA synthesis from the leader ( le ) and trailer-complement ( trc ) promoters. The RdRp can also add nucleotides to the 3′ end of the trc promoter by back-priming, but there is no evidence...
作者:Xin-Lai Sun , Robert B. Johnson , Michelle A. Hockman ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2000, Vol.268 (3), pp.798-803Elsevier
摘要:Abstract(#br)The 65 kDa RNA-dependent RNA polymerase (NS5B), encoded by the hepatitis C virus (HCV) genome, is a key component involved in viral replication. Here we provide the direct evidence that purified HCV polymerase catalyzed de novo RNA synthesis in a primer-independent m...
作者:William P. Kennedy , Jamila R. Momand , Y. Whitney Yin
来源:[J].Journal of Molecular Biology(IF 3.905), 2007, Vol.370 (2), pp.256-268Elsevier
摘要:Abstract(#br)DNA-directed RNA polymerases are capable of initiating synthesis of RNA without primers, the first catalytic stage of initiation is referred to as de novo RNA synthesis. De novo synthesis is a unique phase in the transcription cycle where the RNA polymerase binds tw...
作者:Robert Glyde , Fuzhou Ye , Milija Jovanovic ...
来源:[J].Molecular Cell(IF 15.28), 2018, Vol.70 (6), pp.1111-1120.e3Elsevier
摘要:Summary(#br)Gene transcription is carried out by multi-subunit RNA polymerases (RNAPs). Transcription initiation is a dynamic multi-step process that involves the opening of the double-stranded DNA to form a transcription bubble and delivery of the template strand deep into t...
作者:Matthew Hiram Taylor , Matthew Ross Buckwalter , Amen Craig Stephenson ...
来源:[J].FEBS Letters(IF 3.582), 2002, Vol.514 (2), pp.199-203Elsevier
摘要:Abstract(#br)We investigated the effects of inhibition of de novo RNA and protein synthesis in ionizing radiation (IR)-induced apoptosis in the human T cell line MOLT-4. We observed that pretreatment with cycloheximide inhibited IR-induced apoptosis. However, pretreatment with ac...

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