全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:De Felice F , Tombolini V , Marampon F ...
来源:[J].Drug Design, Development and Therapy(IF 3.486), 2017, Vol.Volume11, pp.547-552DOAJ
摘要:... It has truly become a field that is intensely linked to molecular genetic alterations, especially DNA-repair defects. Germline breast cancer 1 gene (BRCA1) and breast cancer 2 gene (BRCA2) mutations are implicated in the highest risk of prostate cancer (PC) predisposition ...
作者:Benjamin Schwarz , Anna A. Friedl , Stefanie Girst ...
来源:[J].Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis(IF 3.902), 2019, Vol.816-818Elsevier
摘要:Abstract(#br)The accumulation and spatial distribution of 53BP1, BRCA1 and Rad51, key proteins in DNA double-strand break (DSB) repair, was investigated with high temporal resolution over a time span of 24 h, using STED nanoscopy. DNA lesions were induced by irradiation with...
作者:Keisuke Maruyama , Naoki Nakagawa , Tatsuya Aonuma ...
来源:[J].Scientific Reports(IF 2.927), 2019, Vol.9 (1), pp.1-11DOAJ
摘要:Abstract Apurinic/apyrimidinic endonuclease 1 (APE1) is a multifunctional protein that controls the cellular response to oxidative stress and possesses DNA-repair functions. It has important roles in the progression and outcomes of various diseases; however, its function and ther...
作者:E. Sbano , L. Andreassi , M. Fimiani ...
来源:[J].Archives of Dermatological Research(IF 2.708), 1978, Vol.262 (1), pp.55-61Springer
摘要:Summary(#br)Autoradiographic counting technique was utilized to measure the ultraviolet-induced unscheduled DNA synthesis of skin fibroblasts from 12 patients with chronic actinic keratosis and from 12 healthy donors of about the same age. In order to reveal a possible regional d...
作者:Sridurga Mithraprabhu , Jay Hocking , Malarmathy Ramachandran ...
来源:[J].Cancers, 2019, Vol.11 (7)DOAJ
摘要:... Targeted deep amplicon sequencing (TAS) of matched PL and BM samples from 36 MM patients for DNA-repair and RAS-RAF pathway genes found that DNA-repair genes were present at significantly higher levels in the PL when compared to RAS-RAF mutations ( p = 0.0095). We conclu...
作者:Sirirat Chanvaivit , Panida Navasumrit , Potchanee Hunsonti ...
来源:[J].Mut.Res.-Genetic Toxicology and Environmental Mutagenesis(IF 2.22), 2006, Vol.626 (1), pp.79-87Elsevier
摘要:... Induction of DNA-repair capacity was assessed as a biomarker of early effect. The effects of polymorphisms in a metabolizing gene ( CYP 2E1), in detoxification genes ( NQO 1 and GSTT 1), and in a DNA-repair gene ( XRCC 1, codon 399) on biomarker levels were evaluated. Th...
作者:Marta Pingarilho , Nuno G. Oliveira , Célia Martins ...
来源:[J].Mutation Research - Genetic Toxicology and Environmental Mutagenesis(IF 2.22), 2013, Vol.752 (1-2), pp.1-7Elsevier
摘要:... Furthermore, this report addresses the role of individual genetic polymorphisms in key genes involved in detoxification and DNA-repair pathways (BER, NER, HRR and NHEJ) on the induction of SCE by GA. While AA induced the number of SCE/metaphase only slightly, especially for...
作者:N.S. Raji , A. Surekha , Kalluri Subba Rao
来源:[J].Mechanisms of Ageing and Development(IF 3.264), 1998, Vol.104 (2), pp.133-148Elsevier
摘要:... The ability of the peripheral blood lymphocytes from these subjects to respond to PHA stimulation in vitro and DNA-repair parameters, thereafter as a function of BMI and aging, were studied. The DNA-repair markers like unscheduled DNA synthesis (UDS), activities of DNA polym...
作者:N.S Raji , Kalluri Subba Rao
来源:[J].Mechanisms of Ageing and Development(IF 3.264), 1998, Vol.100 (1), pp.85-101Elsevier
摘要:... The DNA-repair markers like unscheduled DNA synthesis (UDS), activities of DNA polymerases, (Total, β and ε ) and two endodeoxyribonucleases, (UV- and AP-DNases) were assessed in the peripheral lymphocytes of these subjects (under different conditions) along with age a...

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