全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Charles-André Philip , Ido Laskov , Marie-Claude Beauchamp ...
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:... We also highlighted a direct pathway linking PTEN to DNA repair.
作者:Wanzhen Li , Meng Zhang , Caojuan Huang ...
来源:[J].Pathology - Research and Practice(IF 1.213), 2019, Vol.215 (10)Elsevier
摘要:Abstract(#br)As is commonly perceived, polymorphisms in genes of deoxyribonucleic acid (DNA) repair pathway plays a fundamental role in defective DNA repair and mutagenesis prevention and serves to contribute to the individual susceptibility to the development of a variety of...
作者:Katsutoshi Oda , Michihiro Tanikawa , Kenbun Sone ...
来源:[J].International Journal of Clinical Oncology(IF 1.727), 2017, Vol.22 (4), pp.611-618Springer
摘要:Poly (ADP-ribose) polymerase (PARP) inhibitors have attracted much attention as one of the major molecular-targeted therapeutics for inhibiting DNA damage response. The PARP inhibitor, olaparib, has been clinically applied for treating certain recurrent ovarian cancer patients wi...
作者:Wusheng Li , Kai Li , Li Zhao ...
来源:[J].Gene(IF 2.196), 2014, Vol.538 (2), pp.361-365Elsevier
摘要:Abstract(#br)Objective(#br)DNA repair pathway genes have been implicated to play an important role in the development of lung cancer. However, contradictory results are often reported by various studies, making it difficult to interpret them. So in this meta-analysis, we hav...
作者:Chunrong Wang , Zhao Chen , Huirong Peng ...
来源:[J].Neurobiology of Aging(IF 6.166), 2018, Vol.71, pp.267.e5-267.e6Elsevier
摘要:Abstract(#br)It has been reported that DNA repair pathways could modify age at onset (AO) in Huntington disease (HD) and spinocerebellar ataxias. We genotyped 22 SNPs from DNA repair pathways in a large cohort of 798 Chinese Machado-Joseph disease patients to investigate the ...
作者:Marco Simonetta , Inge de Krijger , Judit Serrat ...
来源:[J].Cell Cycle(IF 5.243), 2018, Vol.17 (1), pp.124-136Taylor & Francis
摘要:ABSTRACT(#br)The main pathways for the repair of DNA double strand breaks (DSBs) are non-homologous end-joining (NHEJ) and homologous recombination directed repair (HDR). These operate mutually exclusive and are activated by 53BP1 and BRCA1, respectively. As HDR can only succeed ...
作者:Lei Zhao , Xinye He , Yuxuan Shang ...
来源:[J].Science of the Total Environment(IF 3.258), 2020, Vol.702Elsevier
摘要:... Human DNA repair genes can be identified as important candidate biomarkers to assess IR exposure, while how to find the enough sensitive and specific biomarkers in the DNA repair networks is still challenged and not fully determined. The conserved features of DNA repair pathways...
作者:Shauna M. McKelvey , Karina A. Horgan , Richard A. Murphy
来源:[J].Journal of Trace Elements in Medicine and Biology(IF 1.959), 2015, Vol.29, pp.151-169Elsevier
摘要:Abstract(#br)Lead, an environmental toxin is known to induce a broad range of physiological and biochemical dysfunctions in humans through a number of mechanisms including the deactivation of antioxidants thus leading to generation of reactive oxygen species (ROS) and subsequent DNA...
作者:Yuan Lin , Harvind S. Chahal , Wenting Wu ...
来源:[J].International Journal of Cancer(IF 6.198), 2017, Vol.141 (5), pp.952-957Wiley
摘要:DNA repair plays a critical role in protecting the genome from ultraviolet radiation and maintaining the genomic integrity of cells. Genetic variants in DNA repair‐related genes can influence an individual's DNA repair capacity, which may be related to the risk of developi...
作者:Jing Zhou , Zhi-yue Liu , Cun-bao Li ...
来源:[J].Tumor Biology(IF 2.518), 2015, Vol.36 (4), pp.3017-3023Springer
摘要:... In conclusion, our results suggest that ERCC1 rs11615, ERCC2 rs1799793, and NBN rs1805794 polymorphisms in the DNA repair pathways may influence the response to chemotherapy and OS of gastric cancer.

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