全部文献期刊会议图书|学者科研项目
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作者:Yanli Zhang , Fengzhe Li , Xu Feng ...
来源:[J].BMC Genomics(IF 4.397), 2017, Vol.18 (1)
摘要:... Recent work has revealed a potential link between DNA methylation and prolificacy. However, a genome-wide study that sought to identify potential DNA methylation sites involved in sheep prolificacy indicated that it is still unknown. Here, we aimed to investigate the genome-w...
作者:Puja Sinha , Kiran Singh , Manisha Sachan
来源:[J].BMC Molecular Biology(IF 2.796), 2017, Vol.18 (1)
摘要:DNA methylation is a major epigenetic modification, playing a crucial role in the development and differentiation of higher organisms. DNA methylation is also known to regulate transcription by gene repression. Various developmental genes such as c-mos, HoxB5, Sox11, and Sry show...
作者:Ali Sharifi-Zarchi , Daniela Gerovska , Kenjiro Adachi ...
来源:[J].BMC Genomics(IF 4.397), 2017, Vol.18 (1)
摘要:DNA methylation at promoters is largely correlated with inhibition of gene expression. However, the role of DNA methylation at enhancers is not fully understood, although a crosstalk with chromatin marks is expected. Actually, there exist contradictory reports about positive and ...
作者:Itsuki Taniguchi , Chihiro Iwaya , Keizo Ohnaka ...
来源:[J].Human Genomics, 2017, Vol.11 (1)
摘要:Epidemiological studies of DNA methylation profiles may uncover the molecular mechanisms through which genetic and environmental factors contribute to the risk of multifactorial diseases. There are two types of commonly used DNA bioresources, peripheral blood cells (PBCs) and EBV...
作者:Yu-Hsuan Chuang , Kimberly C. Paul , Jeff M. Bronstein ...
来源:[J].Genome Medicine(IF 3.397), 2017, Vol.9 (1)
摘要:Several articles suggest that DNA methylation levels in blood relate to Parkinson’s disease (PD) but there is a need for a large-scale study that involves suitable population based controls. The purposes of the study were: (1) to study whether PD status is associated with DNA methylation...
作者:Cheng-Jian Xu , Marc Jan Bonder , Cilla Söderhäll ...
来源:[J].BMC Genomics(IF 4.397), 2017, Vol.18 (1)
摘要:DNA methylation has been found to associate with disease, aging and environmental exposure, but it is unknown how genome, environment and disease influence DNA methylation dynamics in childhood.
作者:Jia Zhou , Renee L. Sears , Xiaoyun Xing ...
来源:[J].BMC Genomics(IF 4.397), 2017, Vol.18 (1)
摘要:... While studies have confirmed DNA methylation as a conserved epigenetic mechanism in mammalian development, little is known about the conservation of tissue-specific genome-wide DNA methylation patterns.
作者:Chris P. Verschoor , Lisa M. McEwen , Vikas Kohli ...
来源:[J].BMC Genetics(IF 2.808), 2017, Vol.18 (1)
摘要:... this is also true for patterns of DNA (CpG) methylation. Given that immune cells are particularly sensitive to changes in the concentration of cytokines in their microenvironment, we hypothesized that serum levels of TNF, IL-6, IL-8 and IL-10 would correlate with genome-wide...
作者:Maria Needhamsen , Ewoud Ewing , Harald Lund ...
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)
摘要:The advent of array-based genome-wide DNA methylation methods has enabled quantitative measurement of single CpG methylation status at relatively low cost and sample input. Whereas the use of Infinium Human Methylation BeadChips has shown great utility in clinical studies, no equ...
作者:Stefano Frattini , Emanuele Capra , Barbara Lazzari ...
来源:[J].BMC Genomics(IF 4.397), 2017, Vol.18 (1)
摘要:DNA methylation is a frequently studied epigenetic modification due to its role in regulating gene expression and hence in biological processes and in determining phenotypic plasticity in organisms. Rudimentary DNA methylation patterns for some livestock species are publically av...

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