全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Arthur S. Levine , Luxi Sun , Rong Tan ...
来源:[J].Science China Life Sciences(IF 2.024), 2017, Vol.60 (10), pp.1077-1080Springer
摘要:... All living cells try to faithfully preserve and transmit their genomic information from one generation to the next using DNA repair mechanisms to repair oxidative DNA damage to prevent cancer or premature aging. Oxidative DNA damage comprises a mixture of DNA lesions includin...
作者:Stephen Riffle , Ram Naresh Pandey , Morgan Albert ...
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:... Here we exploit these features to study the activation of DNA damage repair pathways and their correlation to developing hypoxia.
作者:Tayyaba Afsar , Suhail Razak , Muhammad Rashid khan ...
来源:[J].BMC Cancer(IF 3.333), 2017, Vol.17 (1)Springer
摘要:Cisplatin (CP), an effective anticancer agent, carries the risk of impairing testicular function leading to infertility. The present study aimed at evaluating the protective effect of A. hydaspica ethyl acetate extract (AHE) against CP-induced oxidative stress and testicular inju...
作者:Ting-Wen Chung , Shih-Chao Lin , Jui-Hsin Su ...
来源:[J].BMC Complementary and Alternative Medicine(IF 2.082), 2017, Vol.17 (1)Springer
摘要:Sinularin isolated from the cultured soft coral Sinularia flexibilis has been reported to exert potent cytotoxic effects against particular types of cancer. This study was carried out to investigate the cytotoxic effects in sinularin-treated human hepatocellular carcinoma cells, ...
作者:Liang X , Yang Q , Wang W ...
来源:[J].OncoTargets and Therapy(IF 2.073), 2019, Vol.Volume 12, pp.6083-6092DOAJ
摘要:... 3Medical Research Center, Changsha Central Hospital, Changsha, Hunan 410004, People’s Republic of ChinaIntroduction: Cisplatin has been reported to elicit the DNA damage response (DDR) via activation of the ATR-Chk1 pathway, which in turn contributes to the induction o...
作者:Mohammad Sazzadul Islam , Ryo Takano , Tomoki Yokochi ...
来源:[J].BMC Cancer(IF 3.333), 2019, Vol.19 (1), pp.1-11DOAJ
摘要:... By contrast, enforced expression of BMCC1 as well as elevated expression of BMCC1 in response to DNA-damage promotes apoptosis by abrogating Akt-mediated survival pathways. Methods We addressed molecular mechanisms underlying changes in regulation of BMCC1 expression during t...
作者:Anna Palovcak , Wenjun Liu , Fenghua Yuan ...
来源:[J].Cell & Bioscience(IF 3), 2017, Vol.7 (1)Springer
摘要:Persistent dysregulation of the DNA damage response and repair in cells causes genomic instability. The resulting genetic changes permit alterations in growth and proliferation observed in virtually all cancers. However, an unstable genome can serve as a double-edged sword by pro...
作者:Andréa Lúcia Gonçalves da Silva , Thaís Evelyn Karnopp , Augusto Ferreira Weber ...
来源:[J].Multidisciplinary Respiratory Medicine(IF 0.151), 2016, Vol.11 (1)Springer
摘要:Abstract(#br) Background(#br)We hypothesized that the use of oxygen supplementation during aerobic exercise induces less DNA damage than exercise alone.(#br)The aim of this study is to assess the level of DNA damage induced by physical exercise with and without oxygen supplementa...
作者:Na Cao , Jia-Kai Li , Yu-Qing Rao ...
来源:[J].BMC Molecular Biology(IF 2.796), 2016, Vol.17 (1)Springer
摘要:Abstract(#br) Background(#br)Cells respond to DNA damage by activating the phosphatidylinositol-3 kinase-related kinases, p53 and other pathways to promote cell cycle arrest, apoptosis, and/or DNA repair. Here we report that protein palmitoylation, a modification carried out by p...
作者:Wan Liu , Jun Li , Yu-Shu Song ...
来源:[J].Molecular Cancer(IF 5.134), 2017, Vol.16 (1)Springer
摘要:... DNA damage response (DDR) is a series of regulatory events including DNA damage, cell-cycle arrest, regulation of DNA replication, and repair or bypass of DNA damage to ensure the maintenance of genomic stability and cell viability. Here we describe the regulatory mechanisms ...

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