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作者:Salam Pradeep Singh , Bolin Kumar Konwar , Rajib Lochan Bezbaruah ...
来源:[J].Medicinal Chemistry Research(IF 1.612), 2013, Vol.22 (10), pp.4755-4765Springer
摘要:... The cell wall of mycobacteria is characterised by high diaminopimelic acid (DAP) content—an intermediate of the ( S )-lysine biosynthetic pathway and dihydrodipicolinate synthase (DHDPS) enzyme catalyses the first unique reaction of this biosynthesis. Interestingly, the ge...
作者:Salam Pradeep Singh , T. C. Bora , R. L. Bezbaruah
来源:[J].Indian Journal of Microbiology(IF 0.457), 2012, Vol.52 (3), pp.427-432Springer
摘要:... 201 at three different binding site of dihydrodipicolinate synthase (DHDPS) enzyme of MTB. The molecular docking studies suggest that the novel molecule shows favourable interaction at the three different binding sites as compared to five experimentally known inhibitors of DHDPS...
作者:Elena A. Rice , Gary A. Bannon , Kevin C. Glenn ...
来源:[J].Archives of Biochemistry and Biophysics(IF 3.37), 2008, Vol.480 (2), pp.111-121Elsevier
摘要:Abstract(#br)The lysine insensitive Corynebacterium glutamicum dihydrodipicolinate synthase enzyme (cDHDPS) was recently successfully introduced into maize plants to enhance the level of lysine in the grain. To better understand lysine insensitivity of the cDHDPS, we expressed , ...
作者:Berin A. Boughton , Michael D.W. Griffin , Paul A. O’Donnell ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2008, Vol.16 (23), pp.9975-9983Elsevier
摘要:... Enzyme kinetic studies allowed the determination of second-order rate constants of inactivation; and substrate co-incubation studies have shown the inhibitors act at the active-site. Mass spectrometric analyses have further explored the enzyme–inhibitor interaction and det...
作者:Berin A. Boughton , Renwick C.J. Dobson , Juliet A. Gerrard ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2007, Vol.18 (2), pp.460-463Elsevier
摘要:Abstract(#br)Dihydrodipicolinate synthase (DHDPS) is a key enzyme in lysine biosynthesis and a potential antibiotic target. The enzyme catalyses the condensation of ( S )-aspartate semi-aldehyde (ASA) and pyruvate to form dihydrodipicolinate. Constrained diketopimelic acid deriva...
作者:Ellen Erzeel , Pieter Bochaute , Tran T. Thu ...
来源:[J].Plant Molecular Biology(IF 3.518), 2013, Vol.81 (4-5), pp.401-415Springer
摘要:Abstract(#br)Lysine biosynthesis in plants is tightly regulated by feedback inhibition of the end product on the first enzyme of the lysine-specific branch, dihydrodipicolinate synthase (DHDPS). Three complete DHDPS coding sequences and one partial sequence were obtained in Medic...
作者:Singh Salam Pradeep , Bora T C , Bezbaruah R L
来源:[J].Indian journal of microbiology(IF 0.457), 2012, Vol.52 (3), pp.427-32PubMed
摘要:... 201 at three different binding site of dihydrodipicolinate synthase (DHDPS) enzyme of MTB. The molecular docking studies suggest that the novel molecule shows favourable interaction at the three different binding sites as compared to five experimentally known inhibitors of DHDPS...
作者:Garg Aarti , Tewari Rupinder , Raghava Gajendra
来源:[J].BMC Bioinformatics(IF 3.024), 2010, Vol.11 (Suppl+1), pp.S53DOAJ
摘要:... Here, we report identification of potential antitubercular candidates targeting Mtb dihydrodipicolinate synthase (DHDPS) enzyme of the pathway using virtual screening protocols. Results In the present study, we generated three sets of drug-like molecules in order to screen po...
作者:Marc Vauterin , Valérie Frankard , Michel Jacobs
来源:[J].The Plant Journal(IF 6.582), 2000, Vol.21 (3), pp.239-248Wiley
摘要:Summary(#br)Dihydrodipicolinate synthase (DHDPS; EC4.2.1.52) catalyses the first reaction of lysine biosynthesis in plants and bacteria. Plant DHDPS enzymes are strongly inhibited by lysine (I0.5≈ 10 μM), whereas the bacterial enzymes are less (50‐fold) or in...
作者:Erzeel Ellen , Van Bochaute Pieter , Thu Tran T ...
来源:[J].Plant molecular biology, 2013, Vol.81 (4-5), pp.401-15PubMed
摘要:Lysine biosynthesis in plants is tightly regulated by feedback inhibition of the end product on the first enzyme of the lysine-specific branch, dihydrodipicolinate synthase (DHDPS). Three complete DHDPS coding sequences and one partial sequence were obtained in Medicago truncatul...

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