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作者:Amrita Mitra , Monita Muralidharan , Deepsikha Srivastava ...
来源:[J].Hemoglobin(IF 0.894), 2017, Vol.41 (4-6), pp.300-305Taylor & Francis
摘要:Abstract(#br)In general, the reactivity of cysteine residues of proteins is measured by 5,5′-dithiobis(2-nitrobenzoic acid) (DTNB) kinetics using spectrophotometry. Proteins with several cysteine residues may exhibit varying DTNB kinetics but residue level information can on...
作者:László Petri , Péter Ábrányi-Balogh , Petra Regina Varga ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2020, Vol.28 (7)
摘要:... Since covalent and non-covalent interactions are both contributing to the affinity of these compounds, evaluation of their reactivity is a key-step to find feasible warheads. There are well-established HPLC- and NMR-based kinetic assays to tackle this task, however, they u...
作者:S Ramachandran , Bhadresh R Rami , Jayant B Udgaonkar
来源:[J].Journal of Molecular Biology(IF 3.905), 2000, Vol.297 (3), pp.733-745Elsevier
摘要:Abstract(#br)Evidence that proteins may unfold utilizing complex competing pathways comes from a new pulse-labeling protocol in which the change in reactivity of a single cysteine residue in a protein during unfolding is measured, making use of its easily monitored reaction with ...
作者:Norman John Mapes , Christopher Rodriguez , Pradeep Chowriappa ...
来源:[J].Computational and Structural Biotechnology Journal, 2019, Vol.17, pp.90-100Elsevier
摘要:... Cysteine amino acids, due to their reactive nature, are prone to oxidation by these free radicals. Determining which cysteines oxidize within proteins is crucial to our understanding of these chronic diseases. Wet lab techniques, like differential alkylation, to determine whi...
作者:Daniel W Bak , Tyler J Bechtel , Julia A Falco ...
来源:[J].Current Opinion in Chemical Biology(IF 9.471), 2019, Vol.48, pp.96-105Elsevier
摘要:Cysteine residues are concentrated at key functional sites within proteins, performing diverse roles in metal binding, catalysis, and redox chemistry. Chemoproteomic platforms to interrogate the reactive cysteinome have developed significantly over the past 10 years, resulting in...
作者:Jenna Scotcher , David J. Clarke , Stefan K. Weidt ...
来源:[J].Journal of The American Society for Mass Spectrometry(IF 3.592), 2011, Vol.22 (5), pp.888-897Springer
摘要:... The discovery of cysteine-targeting compounds that cause re-activation of mutant p53 and the death of tumor cells in vivo has emphasized the functional importance of p53 thiols. Using a combination of top-down and middle-down FTICR mass spectrometry, we show that of the 10 Cy...
作者:Jenner Bonanata , Lucía Turell , Laura Antmann ...
来源:[J].Free Radical Biology and Medicine(IF 5.271), 2017, Vol.108, pp.952-962Elsevier
摘要:Abstract(#br)Human serum albumin (HSA) has a single reduced cysteine residue, Cys34, whose acidity has been controversial. Three experimental approaches (pH-dependence of reactivity towards hydrogen peroxide, ultraviolet titration and infrared spectroscopy) are used to determ...
作者:Gianluca Miglio
来源:[J].Amino Acids(IF 3.914), 2018, Vol.50 (5), pp.647-652Springer
摘要:... The reactivity of cysteines found in fumarate-sensitive proteins was predicted when the collected data for eight network-type features were analyzed using classification models. Therefore, methods for evaluating the likelihood of a cysteine site to be modified by fumarate cou...

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