全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Dockery LE , Gunderson CC , Moore KN
来源:[J].OncoTargets and Therapy(IF 2.073), 2017, Vol.Volume 10, pp.3029-3037DOAJ
摘要:... Rucaparib’s companion diagnostic FoundationFocus™ CDxBRCA test is the first FDA-approved next-generation sequencing-based companion diagnostic test designed to identify patients likely to respond to rucaparib. This article reviews the mechanisms of action, safety, ap...
作者:Trish Thorne-Nuzzo , Crystal Williams , Alice Catallini ...
来源:[J].Journal of Thoracic Oncology(IF 4.473), 2017Elsevier
摘要:Abstract(#br)Introduction(#br)The availability of high-quality, rigorously validated diagnostic tests that can be broadly implemented is necessary to efficiently identify patients with anaplastic lymphoma kinase (ALK)-positive NSCLC who can potentially benefit from treatment...
作者:Meijuan Li
来源:[J].Statistics in Biopharmaceutical Research(IF 0.511), 2016, Vol.8 (3), pp.355-363Taylor & Francis
摘要:... Hence, opportunities exist for device manufacturers to develop follow-on companion diagnostic devices. A follow-on companion diagnostic is intended to be used with the therapeutic product in the indicated patient population, as in the labeling of the comparator companion diagnostic...
作者:Hofman , Barlesi
来源:[J].Expert Review of Molecular Diagnostics(IF 4.089), 2019, Vol.19 (5), pp.429-438Taylor & Francis
摘要:ABSTRACT(#br)Introduction(#br): Companion diagnostic tests (CDXs) are considered mandatory for decision-making for treatment with targeted therapies in thoracic oncology. The emergence of immunotherapy has also given rise to the development of CDXs. Some CDXs, in particular PD-L1...
作者:Camille C Gunderson , Kathleen N Moore
来源:[J].Expert Review of Molecular Diagnostics(IF 4.089), 2015, Vol.15 (9), pp.1111-1116Taylor & Francis
摘要:Lynparza and its companion diagnostic test, BRACAnalysis were approved by the US FDA in December 2014 for recurrent ovarian cancer in women with a germline BRCA mutation. Women with a deleterious BRCA mutation are predisposed to ovarian cancer due to deficient homologous recombin...
作者:Conde , Hernandez , Prieto ...
来源:[J].Expert Review of Molecular Diagnostics(IF 4.089), 2016, Vol.16 (6), pp.707-713Taylor & Francis
摘要:... The aim of this review is to comment on the recently FDA-approved VENTANA ALK (D5F3) Companion Diagnostic (CDx) Assay. This kit provides high sensitivity and specificity for the detection of ALK rearrangements and seamless integration into the laboratory workflow, with a full...
作者:Gregory S. Zaric
来源:[J].PharmacoEconomics(IF 2.861), 2016, Vol.34 (7), pp.635-644Springer
摘要:Abstract(#br)Many interpretations of personalized medicine, also referred to as precision medicine, include discussions of companion diagnostic tests that allow drugs to be targeted to those individuals who are most likely to benefit or that allow treatment to be designed in a wa...
作者:Meijuan Li , Tinghui Yu , Yun‐Fu Hu
来源:[J].Statistics in Medicine(IF 2.044), 2015, Vol.34 (14), pp.2222-2234Wiley
摘要:... The core capability of personalized medicine is the companion diagnostic devices' (CDx) ability to accurately and precisely stratify patients by their likelihood of benefit (or harm) from a particular therapy. There is no reference in the literature discussing the impact ...
作者:Yi Liu , Szu-Yu Tang , Michael Man ...
来源:[J].Statistics in Biopharmaceutical Research(IF 0.511), 2016, Vol.8 (3), pp.325-333Taylor & Francis
摘要:ABSTRACT(#br)In personalized medicine, continuous biomarker values are often dichotomized to classify patients into target and nontarget populations. For example, baseline hemoglobin A1c (A1C) and Positive and Negative Syndrome Scale (PANSS) measurements are potential biomar...
作者:Laura Caberlotto , Mario Lauria
来源:[J].Expert Review of Molecular Diagnostics(IF 4.089), 2015, Vol.15 (2), pp.255-265Taylor & Francis
摘要:The next generation of biomarkers and companion diagnostics will require the development of technologies capable of conjugating the advances in high-throughput techniques in biology with computational methods. Systems biology is poised to contribute through an integrated view, ca...

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