全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Prateep Pakavathkumar , Anastasia Noël , Clotilde Lecrux ...
来源:[J].Molecular Neurodegeneration(IF 4.007), 2017, Vol.12 (1)Springer
摘要:The activation of the aspartate-specific cysteinyl protease, Caspase-6, is proposed as an early pathogenic event of Alzheimer disease (AD) and Huntington’s disease. Caspase-6 inhibitors could be useful against these neurodegenerative diseases but most Caspase-6 inhibitors hav...
作者:Nelly Godefroy , Bénédicte Foveau , Steffen Albrecht ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.8 (11)DOAJ
摘要:Caspase-6 is an effector caspase that has not been investigated thoroughly despite the fact that Caspase-6 is strongly activated in Alzheimer disease brains. To understand the full physiological impact of Caspase-6 in humans, we investigated Caspase-6 expression. We performed wes...
作者:Hong Zhao , Wenjuan Zhao , Kenghoe Lok ...
来源:[J].Cellular and Molecular Neurobiology(IF 2.293), 2014, Vol.34 (3), pp.369-378Springer
摘要:... Ample evidence has shown that caspase-6 is involved in cognitive impairment and expressed in AD brain. Reactive oxygen species (ROS) can lead to caspase-6 activation and correlate with AD. Here, we transfected human embryonic kidney 293 (HEK 293) cells with Tau 441 plasmid ...
作者:Elaine Waldron-Roby , Janine Hoerauf , Nicolas Arbez ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.10 (10)DOAJ
摘要:... By contrast, caspase-6 is not believed to be influenced by IAPs, and little is known about its regulation. We therefore performed a yeast-two-hybrid screen using a constitutively inactive form of caspase-6 for bait in order to identify novel regulators of caspase-6 activity. ...
作者:Robert Mintzer , Sreemathy Ramaswamy , Kinjalkumar Shah ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.7 (1)DOAJ
摘要:Caspase-6 is a cysteinyl protease implicated in neurodegenerative conditions including Alzheimer's and Huntington's disease making it an attractive target for therapeutic intervention. A greater understanding of the role of caspase-6 in disease has been hampered by a lack of suit...
作者:Dagmar E. Ehrnhoefer , Nicholas S. Caron , Yu Deng ...
来源:[J].Experimental Neurology(IF 4.645), 2016, Vol.283, pp.121-128Elsevier
摘要:... Caspase-6 activation plays an important role in axonal degeneration on the molecular level. Increased activity of caspase-6 has been demonstrated in brain tissue from presymptomatic Huntington disease mutation carriers, and it is an early marker of axonal dysfunction. Since l...
作者:Yunsheng Wang , Deming Zhao , Bo Pan ...
来源:[J].Journal of Molecular Neuroscience(IF 2.891), 2015, Vol.56 (4), pp.966-976Springer
摘要:... In an in vitro prion model, we observed that treatment of rat spinal neurons with the prion peptide, PrP106-126, activated death receptor 6 (DR6, also known as TNFRSF21), caspase-6, caspase-3, and induced axonal degeneration. Knockdown of DR6 by siRNA blocked caspase-6 and ca...
作者:Yuan-Chao Ye , Hong-Ju Wang , Ling Chen ...
来源:[J].International Immunopharmacology(IF 2.417), 2013, Vol.17 (3), pp.548-555Elsevier
摘要:... Subsequently, TNFα administration was accompanied with caspase-6 activation. Inhibition of caspase-6 activity by z-V-E(OMe)-I-D(OMe)-fmk (zVEID) or caspase-6 (p20) siRNA had no effect on necroptosis but promoted TNFα-induced autophagy. Meanwhile, autophagy inhibition furt...
作者:Bibiana K.Y. Wong , Dagmar E. Ehrnhoefer , Rona K. Graham ...
来源:[J].Neurobiology of Disease(IF 5.624), 2015, Vol.76, pp.24-36Elsevier
摘要:... Of particular importance is the site at amino acid (aa) 586 that contains a caspase-6 (Casp6) recognition motif.(#br)Activation of Casp6 occurs presymptomatically in human HD patients and the inhibition of mHTT proteolysis at aa586 in the YAC128 mouse model results in the fu...
作者:Ming Huang , Feng Huang , Hanjun Ma ...
来源:[J].Meat Science(IF 2.754), 2012, Vol.90 (3), pp.536-542Elsevier
摘要:Abstract(#br)The objective was to determine the effect of three different protease inhibitors, caspase-6 specific inhibitor VEID-CHO (N-Acetyl-Val-Glu-Ile-Asp-al), calpain inhibitor leupeptin or calpain inhibitor EGTA on protein degradation, ultrastructure of myofibrils and calpa...

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