全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Lingling Sun , Rui Dong , Xin Xu ...
来源:[J].Journal of Neuroinflammation(IF 4.351), 2017, Vol.14 (1)Springer
摘要:... Accumulated evidence indicates that cannabinoid receptor type 2 (CB2R) can mediate anti-inflammatory and immunomodulatory effects in part by controlling microglial activity. However, the impact of CB2R on postoperative cognition has not been investigated. We hypothesized that...
作者:Teruyo Hosoya , Dai Fukumoto , Takeharu Kakiuchi ...
来源:[J].Journal of Neuroinflammation(IF 4.351), 2017, Vol.14 (1)Springer
摘要:Upregulated levels of 18-kDa translocator proteins (TSPO) and type 2 endocannabinoid receptors (CB2) are considered to reflect different aspects of microglia-related neuroinflammatory responses in the brain. Relative to the increase in the TSPO expression that occurs slightly lat...
作者:Evelyn López-Dyck , Felipa Andrade-Urzúa , Alejandro Elizalde ...
来源:[J].Pharmacological Reports(IF 1.965), 2017Elsevier
摘要:...(#br)Methods(#br)To screen the expression of CB 1 (Cannabinoid receptor 1) and CB 2 (Cannabinoid receptor 2) receptors in arterial rings or isolated smooth muscle cells obtained from the artery, immunocytochemistry, immunohistochemistry, and confocal microscopy were performed....
作者:M. Yu. Bobrov , V. V. Bezuglov , L. G. Khaspekov ...
来源:[J].Bulletin of Experimental Biology and Medicine(IF 0.341), 2017, Vol.163 (2), pp.272-275Springer
摘要:Differential expression of type 1 cannabinoid receptors (CR1) was evaluated at different stages of human skin fibroblast transformation into terminally differentiated neurons. Immunocytochemical staining detected no CR1 on fibroblasts, but their transformation into induced plurip...
作者:Zhen Xu , Xiao-Ai Lv , Qun Dai ...
来源:[J].Molecular Brain(IF 4.202), 2016, Vol.9 (1)Springer
摘要:... Type-1 cannabinoid receptor (CB1) is a G-protein coupled receptor (GPCR) enriched on neuronal plasma membrane. Recent evidences point to the substantial presence of CB1 receptors on neuronal mitochondrial outer membranes (mtCB1) and the activation of mtCB1 influences aerobic ...
作者:Antonietta Gentile , Diego Fresegna , Alessandra Musella ...
来源:[J].Journal of Neuroinflammation(IF 4.351), 2016, Vol.13 (1)Springer
摘要:... Anatomical, biochemical, and pharmacological evidence indicates that type-1 cannabinoid receptor (CB1R) is implicated in the control of emotional behavior and is modulated during inflammatory neurodegenerative diseases such as MS and experimental autoimmune encephalomyel...
作者:Qi-xin Shi , Liu-kun Yang , Wen-long Shi ...
来源:[J].Molecular Brain(IF 4.202), 2017, Vol.10 (1)Springer
摘要:The G protein-coupled receptor 55 (GPR55) is a novel cannabinoid receptor, whose exact role in anxiety remains unknown. The present study was conducted to explore the possible mechanisms by which GPR55 regulates anxiety and to evaluate the effectiveness of O-1602 in the treatment...
作者:Phil Jun Lee , Seung Je Woo , Jun-Goo Jee ...
来源:[J].Molecules(IF 2.428), 2015, Vol.20 (1), pp.1277-1292DOAJ
摘要:... Intriguingly, BDMC-induced apoptosis was reversed with co-treatment of sr144528, a cannabinoid receptor (CBR) 2 antagonist, which was confirmed with genetic downregulation of the receptor using siCBR2. Additionally, incubation with BDMC increased the formation of death-induce...
作者:Rareş-Petru Moldovan , Winnie Deuther-Conrad , Andrew G. Horti ...
来源:[J].Molecules(IF 2.428), 2017, Vol.22 (1)DOAJ
摘要:A small series of indol-3-yl-oxoacetamides was synthesized starting from the literature known N-(adamantan-1-yl)-2-(5-(furan-2-yl)-1-pentyl-1H-indol-3-yl)-2-oxoacetamide (5) by substituting the 1-pentyl-1H-indole subunit. Our preliminary biological evaluation showed that the fluo...
作者:Afeef S. Husni , Christopher R. McCurdy , Mohamed M. Radwan ...
来源:[J].Medicinal Chemistry Research(IF 1.612), 2014, Vol.23 (9), pp.4295-4300Springer
摘要:... Cannabinoid receptors belong to the large superfamily of G protein-coupled receptors. Targeting the cannabinoid receptors has the potential to treat a variety of conditions such as pain, neurodegeneration, appetite, immune function, anxiety, cancer, and others. Developin...

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