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作者:Daniel Rubens Marques Vieira-Filho , Marla Karine Amarante , Cyntia Mayumi Ishibashi ...
来源:[J].Journal of Neuroimmunology(IF 3.033), 2020, Vol.342
摘要:... In the present study, we aimed to verify if CCR5 (rs333) and CXCL12 (rs1801157) allelic variants were associated with NB. For CCR5 (rs333) D32 carriers (OR: 5.96, IC: 2.21–16.06) and for CXCL12 genotype 3′A/3′A (OR:26.18, IC:6.15–111.4) there were statistically s...
作者:Keywan Mortezaee
来源:[J].Life Sciences(IF 2.555), 2020, Vol.249
摘要:... C-X-C chemokine ligand 12 (CXCL12)/C-X-C chemokine receptor type 4 (CXCR4) is the key signaling for such aim. Gathering knowledge about the activity within this axis would deepen our insight into the utmost importance this signaling taken to attract and cross-connect multiple...
作者:Lei Chen , Meng Zhu , Shengping Yu ...
来源:[J].Experimental Cell Research(IF 3.557), 2020, Vol.389 (1)
摘要:... C-X-C motif chemokine ligand 12 (CXCL12, also known as stromal derived factor-1, SDF-1) and its cell surface receptor CXCR4 activate a signaling axis that induces the expression of membrane type-2 matrix metalloproteinase (MT2-MMP), which plays a pivotal role in the invasion ...
作者:Jenna Strickland , Domonique Garrison , Bryan L. Copple
来源:[J].Cytokine(IF 2.518), 2020, Vol.127
摘要:Abstract(#br)Introduction(#br)Cxcl12, or stromal-derived factor-1, is a chemokine produced by several hepatic cell types, including hepatocytes, after liver injury and surgical resection. Studies have revealed that Cxcl12 is important for regeneration of the liver after surgi...
作者:David Hardy , Mylène Fefeu , Aurore Besnard ...
来源:[J].Skeletal Muscle, 2019, Vol.9 (1), pp.19-32
摘要:Abstract(#br)Background(#br)During muscle regeneration, the chemokine CXCL12 (SDF-1) and the synthesis of some specific heparan sulfates (HS) have been shown to be critical. CXCL12 activity has been shown to be heavily influenced by its binding to extracellular glycosaminoglycans...
作者:Nádia Calvo Martins Okuyama , Fernando Cezar-dos-Santos , Érica Romão Pereira ...
来源:[J].Journal of Biomedical Science, 2018, Vol.25 (3), pp.1436-1447
摘要:... Among which CXCL12 stands out, due to its pro-inflammatory features, acting as chemoattractant recruiting immune cells. Several polymorphisms were identified in CXCL12 gene including rs1801157 in the 3′-untranslated region, which is characterized by a substitution of a gu...
作者:Dinesh K. Ahirwar , Mohd W. Nasser , Madhu M. Ouseph ...
来源:[J].Oncogene(IF 7.357), 2018, Vol.37 (32), pp.4428-4442
摘要:Abstract(#br)The chemokine CXCL12 has been shown to regulate breast tumor growth, however, its mechanism in initiating distant metastasis is not well understood. Here, we generated a novel conditional allele of Cxcl12 in mice and used a fibroblast-specific Cre transgene along wit...
作者:Ashraf Mousavi
来源:[J].Immunology Letters(IF 2.337), 2020, Vol.217, pp.91-115
摘要:... Among chemokines, the CXCL12/CXCR4 axis has significantly been studied in numerous cancers and autoimmune diseases. CXCL12 is a homeostatic chemokine, which is acts as an anti-inflammatory chemokine during autoimmune inflammatory responses. In cancer cells, CXCL12 acts as a...
作者:Shuang Chang , Yaning Li , Fang Yuan ...
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2017
摘要:Abstract(#br)CXCL12 overexpression improves neurobehavioral recovery during post-ischemic stroke through multiple mechanisms including promoting endothelial progenitor cells function in animal models. It has been proposed that the monomer and dimer forms possess differential che...
作者:Rik Janssens , Sofie Struyf , Paul Proost
来源:[J].Cytokine and Growth Factor Reviews(IF 8.831), 2018
摘要:Abstract(#br)CXCL12 is a CXC chemokine that traditionally has been classified as a homeostatic chemokine. It contributes to physiological processes such as embryogenesis, hematopoiesis and angiogenesis. In contrast to these homeostatic functions, increased expression of CXCL12...

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