全部文献期刊会议图书|学者科研项目
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作者:Veronika Horkova , Ales Drobek , Daniel Mueller ...
来源:[J].Cell Reports, 2020, Vol.30 (5), pp.1504-1514.e7
摘要:... Our mathematical model and experimental data show that the dynamic regulation of CD4- and CD8-LCK coupling establish the self-reactivity of the peripheral T cell pool. The stoichiometry of the interaction between CD8 and LCK, but not between CD4 and LCK, substantially increas...
作者:Jun Young Hong , Jaechul Lim , Fernando Carvalho ...
来源:[J].Cell(IF 31.957), 2020, Vol.180 (5), pp.847-861.e15
摘要:... Here, we report that perinatal glucocorticoid exposure had long-term consequences and resulted in diminished CD8 T cell response in adulthood and impaired control of tumor growth and bacterial infection. We found that perinatal glucocorticoid exposure resulted in persistent a...
作者:Alma Nazlie Mohebiany , Nishada Shakunty Ramphal , Khalad Karram ...
来源:[J].Cell Reports, 2020, Vol.30 (5), pp.1585-1597.e6
摘要:... Without microglial A20, CD8 + T cells spontaneously infiltrate the CNS and acquire a viral response signature. The combination of infiltrating CD8 + T cells and activated A20-deficient microglia leads to an increase in VGLUT1 + terminals and frequency of spontaneous exci...
作者:Yongyin Li , Libo Tang , Ling Guo ...
来源:[J].Journal of Hepatology(IF 9.858), 2020, Vol.72 (3), pp.420-430
摘要:Background & Aims(#br)Although CD8 + T cell exhaustion hampers viral control during chronic HBV infection, the pool of CD8 + T cells is phenotypically and functionally heterogeneous. Therefore, a specific subpopulation of CD8 + T cells should be further investigated. This st...
作者:Georgia Fousteri , Mirela Kuka
来源:[J].Molecular Immunology(IF 2.645), 2020, Vol.119, pp.101-105
摘要:Abstract(#br)Our knowledge on the development and functions of CXCR5 + CD8 T cells is rudimentary when confronted to other extensively studied CD8 T cell subsets. A decade ago, it became apparent that CD8 T cells possess two additional and rather unexpected functional properties ...
作者:Alexandria C. Wells , Elena L. Pobezinskaya , Leonid A. Pobezinsky
来源:[J].Molecular Immunology(IF 2.645), 2020, Vol.120, pp.67-73
摘要:Abstract(#br)CD8 T cells are among the most vigorous soldiers of the immune system that fight viral infections and cancer. CD8 T cell development, maintenance, activation and differentiation are under the tight control of multiple transcriptional and post-transcriptional networks...
作者:Miguel Cervero , Rafael Torres , Jose Luis Agud ...
来源:[J].Medicina Clinica(IF 1.399), 2016, Vol.146 (5), pp.189-193
摘要:Abstract(#br)Background and objective(#br)It has been postulated that the inversion of the CD4:CD8 ratio as a hallmark of immunosenescence can be an independent factor that can herald the risk of co-morbidities. We studied the influence of aging and inversion of the CD4:CD8 ratio...
作者:Noé Rodríguez-Rodríguez , Iris K. Madera-Salcedo , Emmanuel Bugarin-Estrada ...
来源:[J].Clinical Immunology(IF 3.771), 2020, Vol.212
摘要:Abstract(#br)CD8 T cells can kill malignant cells in an antigen-specific manner. However, anti-tumoral responses are usually limited by suppressive factors that curb the effector responses of tumor-infiltrating CD8 T cells. Therapeutic strategies to overcome intra-tumoral T cell...
作者:Jong Hoon Kim , Ji Won Han , Young Joon Choi ...
来源:[J].Journal of Hepatology(IF 9.858), 2020
摘要:Background & Aims(#br)Human liver CD69 + CD8 + T cells are ~95% CD103 - and ~5% CD103 + . Although CD69 + CD103 + CD8 + T cells show tissue residency and robustly respond to antigens, CD69 + CD103 - CD8 + T cells are not yet well understood.(#br)Methods(#br)Liver perfusate and...
作者:Minghui Bai , Youwei Zheng , Haichao Liu ...
来源:[J].Experimental Cell Research(IF 3.557), 2017, Vol.361 (1), pp.39-45
摘要:... New immunotherapeutic strategies that aim at improving antitumor cytotoxic CD8 + T cell responses are being developed in solid tumors. To assist the development of immunotherapies, we investigated the CD8 + T cells in pancreatic cancer patients. Compared to healthy individu...

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