全部文献期刊会议图书|学者科研项目
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作者:Jia-Hua Zhang , Jia-Hui Deng , Xia-Li Yao ...
来源:[J].Experimental Cell Research(IF 3.557), 2020, Vol.386 (1)
摘要:... CD4 + CD25 + regulatory T cells (Tregs) are crucial in maintaining immune tolerance and immune homeostasis, but their role in the pathogenesis of PF is controversial and still unclear. We here explored the relationship between peripheral blood CD4 + CD25 + Tregs and the c...
作者:Veronika Horkova , Ales Drobek , Daniel Mueller ...
来源:[J].Cell Reports, 2020, Vol.30 (5), pp.1504-1514.e7
摘要:... Our mathematical model and experimental data show that the dynamic regulation of CD4- and CD8-LCK coupling establish the self-reactivity of the peripheral T cell pool. The stoichiometry of the interaction between CD8 and LCK, but not between CD4 and LCK, substantially increas...
作者:Shiva Hassanzadeh-Behbahani , Kyle F. Shattuck , Margarita Bronshteyn ...
来源:[J].NeuroImage: Clinical, 2020, Vol.25
摘要:Abstract(#br)Background(#br)The history of immune suppression, especially CD4 nadir, has been shown to be a strong predictor of HIV-associated neurocognitive disorders (HAND). However, the potential mechanism of this association is not well understood.(#br)Methods(#br)High res...
作者:Siyu Yang , Wanyu Li , Zhaowei Fan ...
来源:[J].Microbial Pathogenesis(IF 1.974), 2020
摘要:... However, CD4 + T cell epitopes of GapC that induce CD4 + T cell immune responses are currently unclear. In this study, we used bioinformatics prediction algorithms to predict CD4 + T cell epitopes of GapC. Ten peptides were synthesized to investigate the candidate epitopes...
作者:Hung Bao Tran , Putri Nurhanida Rizky , Stanley Rob McDaniel Padgett ...
来源:[J].Fish and Shellfish Immunology(IF 2.964), 2020, Vol.99, pp.239-242
摘要:Abstract(#br)The co-receptor CD4 plays an important role in distinguishing between helper T-cell (Th) and cytotoxic T lymphocyte (CTL). In the present study, we investigated the molecular features of CD4-2 cDNA to facilitate understanding of their roles in cobia ( Rachycentron ca...
作者:Hassan Ashfaq , Mansour El-Matbouli , Hatem Soliman
来源:[J].Developmental and Comparative Immunology(IF 3.238), 2020, Vol.107
摘要:Abstract(#br)CD4 + cells are vital in coordinating the immune response against pathogens. In the present study, three different CD4 homologs, namely, CD4-1, CD4-2a, and CD4-2b were identified and characterized. Further, their basal expression levels in different brown trout ( Sal...
作者:Sen Han , Zhijie Lin , Jianqiang Wen ...
来源:[J].International Immunopharmacology(IF 2.417), 2020, Vol.81
摘要:...1 − CD4 + NKG2D + T cells are a subpopulation of regulatory T cells that produce TGF-β1 and IL-10. Whether astilbin directly promotes the induction of NK1.1 − CD4 + NKG2D + T cells and whether these astilbin-stimulated T cells exert an immune-regulatory role remain u...
作者:Mohammad Mirzakhani , Mehdi Shahbazi , Roghayeh Akbari ...
来源:[J].Transplant Immunology(IF 1.52), 2020
摘要:... By using flow cytometer, the frequencies of CD4 + CD25 ++ CD45RA − Foxp3 hi activated Tregs (aTregs), CD4 + CD25 + CD45RA + Foxp3 lo resting Tregs (rTregs), CD4 + CD25 + CD45RA − Foxp3 lo non-suppressive T cells, CD4 + CD25 + Foxp3 − cells Teff, and total Tregs were...
作者:Xiang Xie , Qingyi Zhang , Ping Zhang ...
来源:[J].Human Immunology(IF 2.298), 2019, Vol.80 (12), pp.1012-1019
摘要:... Here, we present a proof-of-concept study of the effect of PMMA on CD4 T cells. Using particulate PMMA, a material that resembled wear debris in orthopedic implants, to stimulate whole peripheral blood mononuclear cells, we found that the expression of IFNgamma, IL-4, IL-17, ...
作者:Awoke Seyoum , Principal Ndlovu , Zewotir Temesgen
来源:[J].AIDS Research and Therapy, 2017, Vol.14 (1)
摘要:Adherence and CD4 cell count change measure the progression of the disease in HIV patients after the commencement of HAART. Lack of information about associated factors on adherence to HAART and CD4 cell count reduction is a challenge for the improvement of cells in HIV positive ...

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