全部文献期刊会议图书|学者科研项目
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作者:Chun-Ting Lee , Raphael M. Bendriem , Wells W. Wu ...
来源:[J].Journal of Biomedical Science, 2017, Vol.24 (1)
摘要:Three-dimensional (3D) brain organoids derived from human pluripotent stem cells (hPSCs), including embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs), appear to recapitulate the brain’s 3D cytoarchitectural arrangement and provide new opportunities to e...
作者:Hui Tang , Ying Tang , Tao Zeng ...
来源:[J].BMC Genomics(IF 4.397), 2020, Vol.21 (5), pp.7368-7383
摘要:Abstract(#br)Background(#br)Postpartum developmental delay has been proposed as an important phenotype of human evolution which contributes to many human-specific features including the increase in brain size and the advanced human-specific cognitive traits. However, the biologic...
作者:Helen Spiers , Eilis Hannon , Leonard C. Schalkwyk ...
来源:[J].BMC Genomics(IF 4.397), 2017, Vol.18 (1)
摘要:Epigenetic processes play a key role in orchestrating transcriptional regulation during the development of the human central nervous system. We previously described dynamic changes in DNA methylation (5mC) occurring during human fetal brain development, but other epigenetic proce...
作者:Birkan Tunç , Lisa D. Yankowitz , Drew Parker ...
来源:[J].Molecular Autism, 2019, Vol.10 (2), pp.1627-1638
摘要:... The degree to which the brain development in ASD deviates from typical brain development, and how this deviation relates to observed behavioral outcomes at the individual level are not well-studied. We hypothesize that the degree of deviation from typical brain development...
作者:Nandita Vijayakumar , Kathryn L. Mills , Aaron Alexander-Bloch ...
来源:[J].Developmental Cognitive Neuroscience(IF 3.16), 2018, Vol.33, pp.129-148
摘要:Abstract(#br)Continued advances in neuroimaging technologies and statistical modelling capabilities have improved our knowledge of structural brain development in children and adolescents. While this has provided an increasingly nuanced understanding of brain development, the fie...
作者:Shugui Wang , Louise Harvey , Rocio Martin ...
来源:[J].Neuroscience and Biobehavioral Reviews(IF 9.44), 2018
摘要:... Disruptions in the evolving gut microbiota during this critical developmental period can impact brain development. Communication between the microbiota, gut and brain is driven by hormonal and neural regulation, as well as immune and metabolic pathways, however, our unde...
作者:N.K. Moog , S. Entringer , C. Heim ...
来源:[J].Neuroscience(IF 3.122), 2017, Vol.342, pp.68-100
摘要:Abstract(#br)Thyroid hormones (THs) play an obligatory role in many fundamental processes underlying brain development and maturation. The developing embryo/fetus is dependent on maternal supply of TH. The fetal thyroid gland does not commence TH synthesis until mid gestation, an...
作者:Karen L. Lindsay , Claudia Buss , Pathik D. Wadhwa ...
来源:[J].Biological Psychiatry(IF 9.247), 2018
摘要:Abstract(#br)Growing evidence supports an important role for the intrauterine environment in shaping fetal development and subsequent child health and disease risk. The fetal brain is particularly plastic, whereby even subtle changes in structure and function produced by in utero...
作者:Ana Paula Ardais , Andréia S. Rocha , Maurício Felisberto Borges ...
来源:[J].Behavioural Brain Research(IF 3.327), 2016, Vol.303, pp.76-84
摘要:... In moderate doses, it affords a beneficial effect in adults and upon aging, but has a deleterious effect during brain development. We now tested if caffeine consumption by rats (0.1, 0.3, 1.0 g/L in the drinking water, only during active cycle and weekdays) during adulthood c...
作者:Pieter Vancamp , Veerle M. Darras
来源:[J].General and Comparative Endocrinology(IF 2.823), 2017
摘要:... However, where and when exactly a lack of MCT8 causes the neurological manifestations remains unclear because of the varying expression pattern of MCT8 between specific brain regions and cells. Here, we elaborate on the animal models that have been generated to elucidate the ...

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