全部文献期刊学位论文会议报纸专利标准年鉴图书|学者科研项目
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作者:Jian-Hua Lei , Xu Yang , Xin-Qiang Xiao ...
来源:[J].BMC Gastroenterology(IF 2.11), 2017, Vol.17 (1)Springer
摘要:European researchers have underscored associations between single nucleotide polymorphism (SNP) rs2287622 of the hepatobiliary bile salt export pump (BSEP) gene and the risk of hepatitis C virus (HCV) infection. The distributions of SNP rs2287622 are racially specific. This study...
作者:Anthony Markham
来源:[J].Drugs(IF 4.633), 2017, Vol.77 (7), pp.793-798Springer
摘要:Telotristat ethyl (Xermelo™) is a peripheral tryptophan hydroxylase (TPH) inhibitor that was developed by Lexicon Pharmaceuticals, Inc. for the treatment of carcinoid syndrome. Many neuroendocrine tumours secrete serotonin (5-HT) into the blood stream, resulting in a number ...
作者:Sankalp Jain , Melanie Grandits , Lars Richter ...
来源:[J].Journal of Computer-Aided Molecular Design(IF 3.172), 2017, Vol.31 (6), pp.507-521Springer
摘要:The bile salt export pump (BSEP) actively transports conjugated monovalent bile acids from the hepatocytes into the bile. This facilitates the formation of micelles and promotes digestion and absorption of dietary fat. Inhibition of BSEP leads to decreased bile flow and accum...
作者:Yaofeng Cheng , Thomas F. Woolf , Jinping Gan ...
来源:[J].Chemico-Biological Interactions(IF 2.967), 2016, Vol.255, pp.23-30Elsevier
摘要:Abstract(#br)The bile salt export pump protein (BSEP), expressed on the canalicular membranes of hepatocytes, is primarily responsible for the biliary excretion of bile salts. The inhibition of BSEP transport activity can lead to an increase in intracellular bile salt levels and ...
作者:Tatehiro Kagawa , Reiko Orii , Shunji Hirose ...
来源:[J].Journal of Gastroenterology(IF 3.788), 2014, Vol.49 (5), pp.890-899Springer
摘要:Abstract(#br) Background(#br)Ursodeoxycholic acid (UDCA) partly exerts choleretic effects by modifying the function of the bile salt export pump (Bsep, ABCB11). UDCA induces insertion of Bsep into the canalicular membrane of hepatocytes; however, underlying mechanisms remain unkn...
作者:Viroj Wiwanitkit
来源:[J].HPB(IF 1.939), 2007, Vol.9 (6), pp.444-446Elsevier
摘要:... The bile salt export pump mediates uphill canalicular bile acid secretion. Inherited dysfunction of the bile salt export pump causes a progressive and a benign form of familial intrahepatic cholestasis. Mutations within the bile salt export pump gene are reported. Presently,...
作者:Takashi Misawa , Hisamitsu Hayashi , Yuichi Sugiyama ...
来源:[J].Bioorganic & Medicinal Chemistry(IF 2.903), 2012, Vol.20 (9), pp.2940-2949Elsevier
摘要:Abstract(#br)Progressive familial intrahepatic cholestasis type 2 (PFIC2) is caused by hereditary mutations of bile salt export pump (BSEP), such as E297G BSEP, which is a folding-defective mutant that is unable to traffic beyond the endoplasmic reticulum (ER). 4-Phenylbutyric ac...
作者:Takashi Misawa , Hisamitsu Hayashi , Makoto Makishima ...
来源:[J].Bioorganic & Medicinal Chemistry Letters(IF 2.338), 2012, Vol.22 (12), pp.3962-3966Elsevier
摘要:Abstract(#br)Bile salt export pump (BSEP) is a member of the ATP-binding cassette transmembrane transporter family and mediates biliary excretion of bile acids from hepatocytes. Several BSEP mutants, including Glu297Gly (E297G) and Asp482Gly (D482G), cause progressive familial ...
作者:Steven A. Lacy , Dale R. Miles , Linh T. Nguyen
来源:[J].Clinical Pharmacokinetics(IF 6.109), 2017, Vol.56 (5), pp.477-491Springer
摘要:... Cabozantinib AUC was decreased by 76–77 % with concomitant cytochrome P450 3A4 inducer rifampin, and was unaffected following administration of proton pump inhibitor esomeprazole. Cabozantinib is a potent in vitro inhibitor of P-glycoprotein, and multidrug and toxin ext...
作者:Eiichiro Ogimura , Shuichi Sekine , Toshiharu Horie
来源:[J].Biochemical and Biophysical Research Communications(IF 2.406), 2011, Vol.416 (3-4), pp.313-317Elsevier
摘要:... Among the various mechanisms of liver injury, the accumulation of bile acids (BAs) within hepatocytes is thought to be a primary mechanism for the development of DILI. Although bile salt export pump (BSEP) dysfunction is considered a susceptibility factor for DILI, little is ...

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