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作者:Youn-Kyung Kim , Michael V. Zuccaro , Brianna K. Costabile ...
来源:[J].Archives of Biochemistry and Biophysics(IF 3.37), 2015, Vol.572, pp.11-18
摘要:Abstract(#br)In mammals, β-carotene-15,15′-oxygenase (BCO1) is the main enzyme that cleaves β-carotene, the most abundant vitamin A precursor, to generate retinoids (vitamin A derivatives), both in adult and developing tissues. We previously reported that, in addition to t...
作者:Shiva Raghuvanshi , Vanessa Reed , William S. Blaner ...
来源:[J].Archives of Biochemistry and Biophysics(IF 3.37), 2015, Vol.572, pp.19-27
摘要:... β-Carotene 15,15′ oxygenase-1 (BCO1) and β-carotene 9′,10′ oxygenase-2 (BCO2) are the two known carotenoid cleavage enzymes in humans. BCO1 and BCO2 are highly expressed in liver and intestine. Hepatocytes and hepatic stellate cells are two main cell types involve...
作者:C. Praud , S. Al Ahmadieh , E. Voldoire ...
来源:[J].Experimental Cell Research(IF 3.557), 2017, Vol.358 (2), pp.140-146
摘要:Abstract(#br)The enzyme β-carotene oxygenase 1 (BCO1) catalyzes the breakdown of provitamin A, including beta-carotene (BC), into retinal, prior to its oxidation into retinoic acid (RA). Allelic variation at the BCO1 locus results in differential expression of its mRNA and af...
作者:Ji Ye Lim , Chun Liu , Kang-Quan Hu ...
来源:[J].Archives of Biochemistry and Biophysics(IF 3.37), 2018, Vol.654, pp.1-9
摘要:Abstract(#br)β-Carotene-15, 15′-oxygenase (BCO1) and β-carotene-9′, 10′-oxygenase (BCO2) are essential enzymes in carotenoid metabolism. While BCO1/BCO2 polymorphisms have been associated with alterations to human and animal carotenoid levels, experimental studies ha...
作者:Suemi Yabuta , Masanori Urata , Roseline Yap Wai Kun ...
来源:[J].PLoS ONE(IF 3.73), 2017, Vol.11 (12)
摘要:... All subjects were genotyped for three common SNPs: rs6564851 in the β-carotene 15,15'-oxygenase 1 (BCO1) gene, rs2278986 in the scavenger receptor class B member 1 (SCARB1) gene and rs362090 in the intestine-specific homeobox (ISX) gene. Univariate analysis revealed that t...
作者:Binxing Li , Preejith P. Vachali , Zhengqing Shen ...
来源:[J].Experimental Eye Research(IF 3.026), 2017, Vol.159, pp.123-131
摘要:... β-Carotene oxygenases 1 and 2 (BCO1 and BCO2) are the only two carotenoid cleavage enzymes found in animals. Mutations of the bco2 gene may cause accumulation of xanthophyll carotenoids in animal tissues, and BCO1 is involved in regulation of the intestinal absorption of c...
作者:Yoo Sun Kim , Xiaoming Gong , Lewis P. Rubin ...
来源:[J].The Journal of Nutritional Biochemistry(IF 4.552), 2019, Vol.69, pp.31-43
摘要:... β-carotene 15,15′-oxygenase (BCO1) is the main enzyme that catalyzes the first step in vitamin A biosynthesis from pro-vitamin A carotenoids. Retinoids (vitamin A) play a critical role in NB differentiation. However, the biological functions of BCO1 in NB remained to b...
作者:dela Seña Carlo , Narayanasamy Sureshbabu , Riedl Kenneth M ...
来源:[J].The Journal of biological chemistry, 2013, Vol.288 (52), pp.37094-103
摘要:... β-Carotene 15,15'-oxygenase (BCO1) catalyzes the oxidative cleavage of provitamin A carotenoids at the central 15-15' double bond to yield retinal (vitamin A). In this work, we quantitatively describe the substrate specificity of purified recombinant human BCO1 in terms ...
作者:Earl H. Harrison , Rachel E. Kopec
来源:[J].BBA - Molecular and Cell Biology of Lipids(IF 4.134), 2020
摘要:... β-Carotene 15,15′-dioxygenase (BCO1) catalyzes the oxidative cleavage of the central 15,15′ carbon-carbon double of β-carotene bond by addition of molecular oxygen. The product of the reaction is retinaldehyde (retinal or β-apo-15-carotenal). Thus, BCO1 is the enzyme ...

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