全部文献期刊会议图书|学者科研项目
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作者:Swapna Nandakumar , Bejoy Vijayan , Asha Kishore ...
来源:[J].Journal of Cell Communication and Signaling, 2017, Vol.11 (4), pp.381-394
摘要:... This poses a limitation to the use of overexpression models for studies on α-syn clearance by autophagy, which is widely investigated for its therapeutic potential. This limitation can be overcome with the use of endogenous models. In this study, SK-MEL-28, a melanoma cell...
作者:Yuqing Chen , Xin Zhou , Jianou Qiao ...
来源:[J].Journal of Cell Communication and Signaling, 2017, Vol.11 (3), pp.219-226
摘要:Autophagy, a catabolic process by which cytoplasmic components are degraded in lysosomes, plays an important role in the maintenance of cellular homeostasis. Dysregulation of autophagy is associated with several diseases. However, few studies have addressed the role of autophagy ...
作者:S.N. Suresh , Anushka Chakravorty , Mridhula Giridharan ...
来源:[J].Journal of Molecular Biology(IF 3.905), 2020
摘要:Abstract(#br)Considerable evidences suggest a link between autophagy dysfunction, protein aggregation, and neurodegenerative diseases. Given that autophagy is a conserved intracellular housekeeping process, modulation of autophagy flux in various model organisms have highlighted ...
作者:Anja Petrović , Desanka Bogojević , Aleksandra Korać ...
来源:[J].Journal of Physiology and Biochemistry(IF 1.654), 2017, Vol.73 (4), pp.511-521
摘要:... In the present study, we examined whether alleviation of diabetes-attendant oxidative stress and ensuing change in HMGB1 expression influence the dynamic equilibrium between apoptosis/autophagy and liver damage. We observed that elevated HMGB1 protein levels in diabetic rat l...
作者:Oliver Philipp , Andrea Hamann , Heinz D. Osiewacz ...
来源:[J].BMC Bioinformatics(IF 3.024), 2017, Vol.18 (1)
摘要:Autophagy is a conserved molecular pathway involved in the degradation and recycling of cellular components. It is active either as response to starvation or molecular damage. Evidence is emerging that autophagy plays a key role in the degradation of damaged cellular components a...
作者:Maximilian Schütter , Patrick Giavalisco , Susanne Brodesser ...
来源:[J].Cell(IF 31.957), 2020, Vol.180 (1), pp.135-149.e14
摘要:Summary(#br)Autophagy is a conserved catabolic homeostasis process central for cellular and organismal health. During autophagy, small single-membrane phagophores rapidly expand into large double-membrane autophagosomes to encapsulate diverse cargoes for degradation. It is though...
作者:Nipa H. Patel , Jingwen Xu , Tareq Saleh ...
来源:[J].Biochemical Pharmacology(IF 4.576), 2020, Vol.175
摘要:Abstract(#br)While therapy-induced autophagy is conventionally conceived to be cytoprotective in nature, previous studies have identified multiple functions of autophagy, including a nonprotective form, as well as the existence of a switch between the different forms of autophagy...
作者:Adel Hammoutene , Louise Biquard , Juliette Lasselin ...
来源:[J].Journal of Hepatology(IF 9.858), 2020, Vol.72 (3), pp.528-538
摘要:Background & Aims(#br)Previous studies demonstrated that autophagy is protective in hepatocytes and macrophages, but detrimental in hepatic stellate cells in chronic liver diseases. The role of autophagy in liver sinusoidal endothelial cells (LSECs) in non-alcoholic steatohepat...
作者:Jan Gunst
来源:[J].Critical Care, 2017, Vol.21 (1)
摘要:Autophagy is a catabolic process by which cells can dispose of damaged content and intracellular microorganisms. Recent evidence implicates autophagy as a crucial repair process necessary to recover from critical illness-induced organ failure. Withholding parenteral nutrition in ...
作者:Hong Zhao , Yiqun Wang , Tingting Qiu ...
来源:[J].Clinica Chimica Acta(IF 2.85), 2020, Vol.502, pp.139-147
摘要:Abstract(#br)As an evolutionarily conserved intracellular degradation pathway, autophagy is essential to cellular homeostasis. Several studies have demonstrated that autophagy showed an important effect on some pulmonary fibrosis diseases, including idiopathic pulmonary fibrosis ...

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